Patient demographics and disease characteristics
| Patient demographics . | 2012-2018 multi-institution cohort (N = 789) . | 2018-2022 The University of Chicago cohort (N = 330) . |
|---|---|---|
| Age at AML diagnosis, y | n = 788 | n = 330 |
| Median age (range) | 62 (18-95) | 69 (18-92) |
| Age 18-59, n (%) | 350 (44) | 78 (24) |
| Age 60-74, n (%) | 313 (40) | 160 (48) |
| Age 75+, n (%) | 125 (16) | 92 (28) |
| Sex, n (%) | ||
| Male | 427 (54) | 192 (58) |
| Female | 362 (46) | 138 (42) |
| Race/ethnicity, n (%) | n = 789 | n = 302 |
| NHW | 473 (60) | 212 (70) |
| NHB | 121 (15) | 54 (18) |
| Hispanic | 118 (15) | 22 (7) |
| Other | 77 (10) | 14 (5) |
| ELN 2022 categorization, n (%) | n = 330 | |
| Favorable | 57 (17) | |
| Intermediate | 66 (20) | |
| Adverse | 207 (63) | |
| ELN 2010 categorization, n (%) | n = 750 | |
| Favorable | 112 (15) | |
| Intermediate 1 | 280 (37) | |
| Intermediate 2 | 136 (18) | |
| Adverse | 222 (30) | |
| TP53 mutation status tested | n = 512 | n = 330 |
| Pathogenic mutation, n (%) | 43 (8) | 74 (22) |
| No pathogenic mutation, n (%) | 469 (92) | 256 (78) |
| Patient demographics . | 2012-2018 multi-institution cohort (N = 789) . | 2018-2022 The University of Chicago cohort (N = 330) . |
|---|---|---|
| Age at AML diagnosis, y | n = 788 | n = 330 |
| Median age (range) | 62 (18-95) | 69 (18-92) |
| Age 18-59, n (%) | 350 (44) | 78 (24) |
| Age 60-74, n (%) | 313 (40) | 160 (48) |
| Age 75+, n (%) | 125 (16) | 92 (28) |
| Sex, n (%) | ||
| Male | 427 (54) | 192 (58) |
| Female | 362 (46) | 138 (42) |
| Race/ethnicity, n (%) | n = 789 | n = 302 |
| NHW | 473 (60) | 212 (70) |
| NHB | 121 (15) | 54 (18) |
| Hispanic | 118 (15) | 22 (7) |
| Other | 77 (10) | 14 (5) |
| ELN 2022 categorization, n (%) | n = 330 | |
| Favorable | 57 (17) | |
| Intermediate | 66 (20) | |
| Adverse | 207 (63) | |
| ELN 2010 categorization, n (%) | n = 750 | |
| Favorable | 112 (15) | |
| Intermediate 1 | 280 (37) | |
| Intermediate 2 | 136 (18) | |
| Adverse | 222 (30) | |
| TP53 mutation status tested | n = 512 | n = 330 |
| Pathogenic mutation, n (%) | 43 (8) | 74 (22) |
| No pathogenic mutation, n (%) | 469 (92) | 256 (78) |