Patient characteristics of IgM gammopathy samples
| Parameter . | IgM gammopathies (n = 29) . | WM (n = 23) . | IgM-MGUS (n = 6) . | P value . |
|---|---|---|---|---|
| Age at diagnosis, y | 61 (46-80) | 61 (47-80) | 65 (52-78) | .51 |
| Male sex, n (%) | 16 (55) | 13 (57) | 3 (50) | .78 |
| Hemoglobin, g/dL | 11.7 (8.1-16.2) | 11.6 (8.1-15.8) | 12.6 (11.1-16.2) | .17 |
| Platelets, ×109/L | 235 (77-512) | 222 (77-512) | 262 (207-338) | .28 |
| β2-Microglobulin, μg/mL | 3.1 (1.4-16.7) | 3.1 (1.6-16.7) | 2.8 (1.4-3.2) | .52 |
| IgM, mg/dL | 1770 (173-10 000) | 3340 (173-10 000) | 575 (283-1770) | .01 |
| BM involvement, % | 35 (0-95) | 50 (10-95) | 3.5 (0-10) | <.001 |
| Abnormal FLC ratio, n (%) | 7 (24) | 5 (28) | 2 (50) | .39 |
| MYD88 mutated, n (%) | 19 (83) | 16 (84) | 3 (75) | .66 |
| CXCR4 mutated, n (%) | 6 (26) | 6 (32) | 0 | .19 |
| Dx to LFU, mo | 92 (3-201) | 92 (3-194) | 87 (26-201) | .94 |
| Parameter . | IgM gammopathies (n = 29) . | WM (n = 23) . | IgM-MGUS (n = 6) . | P value . |
|---|---|---|---|---|
| Age at diagnosis, y | 61 (46-80) | 61 (47-80) | 65 (52-78) | .51 |
| Male sex, n (%) | 16 (55) | 13 (57) | 3 (50) | .78 |
| Hemoglobin, g/dL | 11.7 (8.1-16.2) | 11.6 (8.1-15.8) | 12.6 (11.1-16.2) | .17 |
| Platelets, ×109/L | 235 (77-512) | 222 (77-512) | 262 (207-338) | .28 |
| β2-Microglobulin, μg/mL | 3.1 (1.4-16.7) | 3.1 (1.6-16.7) | 2.8 (1.4-3.2) | .52 |
| IgM, mg/dL | 1770 (173-10 000) | 3340 (173-10 000) | 575 (283-1770) | .01 |
| BM involvement, % | 35 (0-95) | 50 (10-95) | 3.5 (0-10) | <.001 |
| Abnormal FLC ratio, n (%) | 7 (24) | 5 (28) | 2 (50) | .39 |
| MYD88 mutated, n (%) | 19 (83) | 16 (84) | 3 (75) | .66 |
| CXCR4 mutated, n (%) | 6 (26) | 6 (32) | 0 | .19 |
| Dx to LFU, mo | 92 (3-201) | 92 (3-194) | 87 (26-201) | .94 |
All characteristics at the time of sample collection. IgM-gammopathies group contained all WM and IgM-MGUS samples. FLC data were available in 22 patients (18 WM, 4 IgM-MGUS). MYD88 and CXCR4 mutational data were available in 23 patients (19 WM, 4 IgM-MGUS). Unless specified, values represent median (range). Values in bold reach the signficance threshold of P < 0.05.
B2, β-2; BM, bone marrow; Dx, diagnosis; FLC, free light chain; IgM, immunoglobulin M; LFU, last follow-up.