Distribution of measurement results [n. (%)] in the 3 classes of standardized C-trough values in patients with AF who received appropriate or inappropriate standard- or low-dose DOAC and incidence of bleeding events in the classes
| Standardized C-trough value classes . | ||||
|---|---|---|---|---|
| . | Low levels . | Intermediate levels . | High levels . | All . |
| ≤ −0.50 . | From −0.49 to 0.50 . | > 0.50 . | ||
| DOAC doses and incidence of bleeds in the classes, n (% pt/yrs) | ||||
| Standard dose | 309 (32.3) | 459 (48.0) | 189 (19.7) | 957 |
| Appropriate, n (%) | 294 (17.7) | 413 (24.9) | 174 (10.5) | 881 (53.2) |
| Incidence of bleeding events, n (% pt/yrs) | 6/287 (2.1) | 8/415 (1.9) | 5/167 (3.0) | 19/869 (2.2) |
| Inappropriate, n. (%) | 15 (0.9) | 46 (2.8) | 15 (0.9) | 76 (4.6) |
| Incidence of bleeding events, n (% pt/yrs) | 0/16 (0) | 2/44 (4.5) | 0/14 (0) | 2/75 (2.8) |
| Low dose | 222 (31.7) | 345 (49.3) | 133 (19.0) | 700 |
| Appropriate, n (%) | 180 (10.5) | 282 (17.0) | 98 (5.9) | 560 (33.8) |
| Incidence of bleeding events, n (% pt/yrs) | 6/177 (3.4) | 7/272 (2.6) | 7/88 (7.9) | 20/537 (3.7) |
| Inappropriate, n (%) | 42 (2.5) | 63 (3.8) | 35 (2.1) | 140 (8.4) |
| Incidence of bleeding events, n (% pt/yrs) | 3/40 (7.5) | 3/60 (5.0) | 3/33 (9.1) | 9/133 (6.8) |
| Standardized C-trough value classes . | ||||
|---|---|---|---|---|
| . | Low levels . | Intermediate levels . | High levels . | All . |
| ≤ −0.50 . | From −0.49 to 0.50 . | > 0.50 . | ||
| DOAC doses and incidence of bleeds in the classes, n (% pt/yrs) | ||||
| Standard dose | 309 (32.3) | 459 (48.0) | 189 (19.7) | 957 |
| Appropriate, n (%) | 294 (17.7) | 413 (24.9) | 174 (10.5) | 881 (53.2) |
| Incidence of bleeding events, n (% pt/yrs) | 6/287 (2.1) | 8/415 (1.9) | 5/167 (3.0) | 19/869 (2.2) |
| Inappropriate, n. (%) | 15 (0.9) | 46 (2.8) | 15 (0.9) | 76 (4.6) |
| Incidence of bleeding events, n (% pt/yrs) | 0/16 (0) | 2/44 (4.5) | 0/14 (0) | 2/75 (2.8) |
| Low dose | 222 (31.7) | 345 (49.3) | 133 (19.0) | 700 |
| Appropriate, n (%) | 180 (10.5) | 282 (17.0) | 98 (5.9) | 560 (33.8) |
| Incidence of bleeding events, n (% pt/yrs) | 6/177 (3.4) | 7/272 (2.6) | 7/88 (7.9) | 20/537 (3.7) |
| Inappropriate, n (%) | 42 (2.5) | 63 (3.8) | 35 (2.1) | 140 (8.4) |
| Incidence of bleeding events, n (% pt/yrs) | 3/40 (7.5) | 3/60 (5.0) | 3/33 (9.1) | 9/133 (6.8) |