Diagnostic workup for MCD
| Purpose . | Tests . |
|---|---|
| Inflammatory response | CBC, renal function, liver function, CRP, ESR, fibrinogen, immunoglobulins and free light chains, albumin, and ferritin |
| Histopathology | Hypervascular/mixed cellularity/plasmacytic variant |
| Virologic status | HIV serology, HHV8 qPCR (peripheral blood), EBER (lymph node), and LANA-1 (lymph node) |
| Cytokine profile | Interleukin-6 and vascular endothelial growth factor |
| Imaging | CT-PET or CT neck, chest, abdomen, and pelvis |
| Bone marrow evaluation | Monoclonal gammopathy of undetermined significance, myeloma, and reticulin fibrosis |
| Immunology | ANA and rheumatoid factor |
| Organ function | Echocardiogram and pulmonary function (additional organ assessment may be needed in severe cases) |
| Purpose . | Tests . |
|---|---|
| Inflammatory response | CBC, renal function, liver function, CRP, ESR, fibrinogen, immunoglobulins and free light chains, albumin, and ferritin |
| Histopathology | Hypervascular/mixed cellularity/plasmacytic variant |
| Virologic status | HIV serology, HHV8 qPCR (peripheral blood), EBER (lymph node), and LANA-1 (lymph node) |
| Cytokine profile | Interleukin-6 and vascular endothelial growth factor |
| Imaging | CT-PET or CT neck, chest, abdomen, and pelvis |
| Bone marrow evaluation | Monoclonal gammopathy of undetermined significance, myeloma, and reticulin fibrosis |
| Immunology | ANA and rheumatoid factor |
| Organ function | Echocardiogram and pulmonary function (additional organ assessment may be needed in severe cases) |
ANA, antinuclear antibody; CBC, complete blood count; CT, computed tomography; EBER, Epstein-Barr virus–encoded small RNAs; ESR, erythrocyte sedimentation rate; LANA, latency-associated nuclear antigen; PET, positron emission tomography; qPCR, quantitative polymerase chain reaction.
Adapted from van Rhee et al5