Study characteristics
| Study . | Country . | Study design . | Mean age (y) . | Male (%) . | Pregnant women (%) . | Severe anemia (Hb, ≤6 g/dL) (%) . | Intervention sample size . | Control sample size . | Intervention agent . | Control agent . | Duration of treatment (d) . |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Astuti et al17 | Indonesia | RCT | 13.68 | 0 | 0 | ND | 11 | 11 | Ferrous sulfate + vitamin C (up to 100 mg daily) | Ferrous sulfate | 180 |
| Aycicek18 | Turkey | RCT | 7.1 | 52.81 | 0 | ND | 44 | 45 | Ferrous fumarate (5 mg/kg per day) + vitamin C (6.3 mg/kg per day) | Ferrous sulfate (5 mg/kg per day) | 45 |
| Chavan et al19 | India | RCT | 23.67 | 0 | 100 | 0 | 50 | 50 | Ferrous ascorbate (100 mg daily) + folic acid | Ferrous sulfate (60 mg bid) + folic acid | 90 |
| Gamad et al20 | India | RCT | 27.78 | 0 | 100 | 0 | 30 | 90 | Ferrous ascorbate (100 mg bid) + folic acid | Ferrous sulfate + folic acid, n = 30, Ferrous fumarate n = 30, and carbonyl iron + folic acid n = 30 (each 100 mg bid) | 56 |
| Ganguly21 | India | RCT | 5.14 | 65 | 0 | 26 | 41 | 39 | Ferrous ascorbate (3 mg/kg per day) + folic acid | Colloidal iron (3 mg/kg per day) + folic acid + vitamin B12 | 84 |
| Li et al10 | China | RCT | 38.3 | 3.18 | ND | ND | 220 | 220 | Ferrous succinate (100 mg tid) + vitamin C (200 mg tid) | Ferrous succinate (100 mg tid) | 90 |
| Panchal et al22 | India | Prospective cohort | 38.5 | 27.70 | 58.11 | ND | 62 | 86 | Ferrous ascorbate (100 mg daily) | Ferrous sulfate (200 mg daily) | 84 |
| Patil et al12 | India | RCT | 1.72 | 49 | 0 | ND | 50 | 50 | Ferrous ascorbate (6 mg/kg per day) | Iron polymaltose complex (6 mg/kg per day) | 90 |
| Rosado et al23 | Mexico | RCT | 1.78 | 47.73 | 0 | 0 | 48 | 40 | Unspecified oral iron (6.7 mg daily) + zinc + vitamin C (44.4 mg daily) | Ferrous sulfate (20 mg daily) | 112 |
| Singhal et al24 | India | RCT | 22.45 | 0 | 100 | ND | 50 | 200 | Ferrous ascorbate (100 mg daily) | Ferrous sulfate (100 mg daily) n = 50, ferrous fumarate (100 mg daily) n = 50, ferrous bisglycinate (30 mg daily) n = 50, and sodium feredetate (33 mg daily), n = 50 | 60 |
| Zlotkin et al25 | Ghana | RCT | 1.07 | 47.46 | 0 | ND | 246 | 247 | Ferrous fumarate (80 mg daily) + vitamin C (50 mg daily) | Ferrous sulfate (40 mg daily, divided into 3 doses) | 60 |
| Study . | Country . | Study design . | Mean age (y) . | Male (%) . | Pregnant women (%) . | Severe anemia (Hb, ≤6 g/dL) (%) . | Intervention sample size . | Control sample size . | Intervention agent . | Control agent . | Duration of treatment (d) . |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Astuti et al17 | Indonesia | RCT | 13.68 | 0 | 0 | ND | 11 | 11 | Ferrous sulfate + vitamin C (up to 100 mg daily) | Ferrous sulfate | 180 |
| Aycicek18 | Turkey | RCT | 7.1 | 52.81 | 0 | ND | 44 | 45 | Ferrous fumarate (5 mg/kg per day) + vitamin C (6.3 mg/kg per day) | Ferrous sulfate (5 mg/kg per day) | 45 |
| Chavan et al19 | India | RCT | 23.67 | 0 | 100 | 0 | 50 | 50 | Ferrous ascorbate (100 mg daily) + folic acid | Ferrous sulfate (60 mg bid) + folic acid | 90 |
| Gamad et al20 | India | RCT | 27.78 | 0 | 100 | 0 | 30 | 90 | Ferrous ascorbate (100 mg bid) + folic acid | Ferrous sulfate + folic acid, n = 30, Ferrous fumarate n = 30, and carbonyl iron + folic acid n = 30 (each 100 mg bid) | 56 |
| Ganguly21 | India | RCT | 5.14 | 65 | 0 | 26 | 41 | 39 | Ferrous ascorbate (3 mg/kg per day) + folic acid | Colloidal iron (3 mg/kg per day) + folic acid + vitamin B12 | 84 |
| Li et al10 | China | RCT | 38.3 | 3.18 | ND | ND | 220 | 220 | Ferrous succinate (100 mg tid) + vitamin C (200 mg tid) | Ferrous succinate (100 mg tid) | 90 |
| Panchal et al22 | India | Prospective cohort | 38.5 | 27.70 | 58.11 | ND | 62 | 86 | Ferrous ascorbate (100 mg daily) | Ferrous sulfate (200 mg daily) | 84 |
| Patil et al12 | India | RCT | 1.72 | 49 | 0 | ND | 50 | 50 | Ferrous ascorbate (6 mg/kg per day) | Iron polymaltose complex (6 mg/kg per day) | 90 |
| Rosado et al23 | Mexico | RCT | 1.78 | 47.73 | 0 | 0 | 48 | 40 | Unspecified oral iron (6.7 mg daily) + zinc + vitamin C (44.4 mg daily) | Ferrous sulfate (20 mg daily) | 112 |
| Singhal et al24 | India | RCT | 22.45 | 0 | 100 | ND | 50 | 200 | Ferrous ascorbate (100 mg daily) | Ferrous sulfate (100 mg daily) n = 50, ferrous fumarate (100 mg daily) n = 50, ferrous bisglycinate (30 mg daily) n = 50, and sodium feredetate (33 mg daily), n = 50 | 60 |
| Zlotkin et al25 | Ghana | RCT | 1.07 | 47.46 | 0 | ND | 246 | 247 | Ferrous fumarate (80 mg daily) + vitamin C (50 mg daily) | Ferrous sulfate (40 mg daily, divided into 3 doses) | 60 |
bid, twice daily; ND, no data; tid, thrice daily.