Table 2. Qualifiers required for... | American Society of Hematology

Table 2.

Qualifiers required for defining pediatric emergent refractory ITP and ITP that fails to respond to disease-modifying therapy

ITP qualifiers = indications + treatments + response + platelets/symptoms
Indications for treatment	Emergent vs disease-modifying therapy
Prior trialed treatments	Pharmacotherapy: administered at appropriate dosing for an adequate duration Interventions (eg, splenectomy)
Treatment response	NR: no response PR PR-t (transient)∗ PR-d (durable)∗ CR CR-t (transient)∗ CR-d (durable)∗
Platelet response/symptom response	Platelet response Symptom response Bleeding Quality of life Fatigue

ITP qualifiers = indications + treatments + response + platelets/symptoms
Indications for treatment	Emergent vs disease-modifying therapy
Prior trialed treatments	Pharmacotherapy: administered at appropriate dosing for an adequate duration Interventions (eg, splenectomy)
Treatment response	NR: no response PR PR-t (transient)∗ PR-d (durable)∗ CR CR-t (transient)∗ CR-d (durable)∗
Platelet response/symptom response	Platelet response Symptom response Bleeding Quality of life Fatigue

The duration of response to define modifiers (transient and durable) to be determined in collaboration with the IWG.