OS for the 7/8 HLA-MMUD HCT weighted samples in the for the abatacept + CNI/MTX vs CNI/MTX comparison cohort
| . | Abatacept + CNI/MTX (n = 54) . | CNI/MTX (n = 161) . | P value∗ . |
|---|---|---|---|
| Day 180 (primary end point) | |||
| OS (95% CI) | 98 (78-100) | 75 (67-82) | .0028 |
| HR (95% CI)† | 0.06 (0.01-0.27) | ||
| 1 y | |||
| OS (95% CI) | 86 (68-95) | 61 (53-69) | .0046 |
| HR (95% CI)† | 0.28 (0.12-0.68) | ||
| 2 y | |||
| OS (95% CI) | 83 (64-92) | 55 (46-63) | .0036 |
| HR (95% CI)† | 0.30 (0.14-0.65) |
| . | Abatacept + CNI/MTX (n = 54) . | CNI/MTX (n = 161) . | P value∗ . |
|---|---|---|---|
| Day 180 (primary end point) | |||
| OS (95% CI) | 98 (78-100) | 75 (67-82) | .0028 |
| HR (95% CI)† | 0.06 (0.01-0.27) | ||
| 1 y | |||
| OS (95% CI) | 86 (68-95) | 61 (53-69) | .0046 |
| HR (95% CI)† | 0.28 (0.12-0.68) | ||
| 2 y | |||
| OS (95% CI) | 83 (64-92) | 55 (46-63) | .0036 |
| HR (95% CI)† | 0.30 (0.14-0.65) |
OS is defined as the time between the date of transplant to the physician documented date of death. Patients were censored at 181 days and 1 year after transplant or at time of last follow-up, whichever is earlier. Propensity scores obtained from a logistic regression model including sex, disease, age, HCT graft source, conditioning intensity, Karnofsky/Lansky performance score, and CNI type, as covariates.
Based on weighted Kaplan-Meier method.
Marginal HR based on weighted Cox proportional hazards model with treatment as the only covariate using a robust variance estimator that accounts for the sample weights. Ties are handled using the Breslow method.