Table 1. JNJ-75276617–inhibited... | American Society of Hematology

Table 1.

JNJ-75276617–inhibited menin-KMT2A binding from various species in HTRF assays

Species of menin	IC₅₀ ± SEM (nM)	pIC₅₀ ± SEM (nM)
Human	0.1 ± 0.016 (n = 10)	10.084 ± 0.081 (n = 10)
Mouse	0.045 ± 0.002 (n = 2)	10.347 ± 0.019 (n = 2)
Dog	≤0.066 ± 0.004 (n = 3)	≥10.180 ± 0.025 (n = 3)

Species of menin	IC₅₀ ± SEM (nM)	pIC₅₀ ± SEM (nM)
Human	0.1 ± 0.016 (n = 10)	10.084 ± 0.081 (n = 10)
Mouse	0.045 ± 0.002 (n = 2)	10.347 ± 0.019 (n = 2)
Dog	≤0.066 ± 0.004 (n = 3)	≥10.180 ± 0.025 (n = 3)

HTRF, homogeneous time-resolved fluorescence; pIC₅₀, negative log10 of the IC₅₀; SEM, standard error of the mean.