Table 2. Multivariate analysis:... | American Society of Hematology

Table 2.

Multivariate analysis: haploidentical vs MSD, propensity-matched cohort

OS	n	Events	Point estimates	HR	95% CI	P
MSD-PTCy	400	177	57.2% (51.9-62.3)	Ref
Haplo-PTCy	1052	471	59.3% (56.3-62.3)	0.94	0.78-1.14	.54
MSD-PTCy	400	177	57.2% (51.9-62.3)	Ref
Haplo: B-leader–matched	635	275	61.7% (57.8-65.5)	0.89	0.72-1.09	.24
Haplo: B-leader–mismatched	417	196	55.8% (50.9-60.6)	1.04	0.84-1.3	.72

OS	n	Events	Point estimates	HR	95% CI	P
MSD-PTCy	400	177	57.2% (51.9-62.3)	Ref
Haplo-PTCy	1052	471	59.3% (56.3-62.3)	0.94	0.78-1.14	.54
MSD-PTCy	400	177	57.2% (51.9-62.3)	Ref
Haplo: B-leader–matched	635	275	61.7% (57.8-65.5)	0.89	0.72-1.09	.24
Haplo: B-leader–mismatched	417	196	55.8% (50.9-60.6)	1.04	0.84-1.3	.72

NRM	N	Events	Point estimates	HR	95% CI	P
MSD-PTCy	396	73	19.9% (14.7-22.5)	Ref
Haplo-PTCy	1039	203	12.1% (16.3-21.0)	0.98	0.72-1.32	.87
MSD-PTCy	396	73	18.5% (14.7-22.5)	Ref
Haplo: B-leader–matched	627	109	16.5% (13.7-19.5)	0.83	0.6-1.15	.27
Haplo: B-leader–mismatched	412	94	21.8% (17.9-25.9)	1.21	0.86-1.69	.27

NRM	N	Events	Point estimates	HR	95% CI	P
MSD-PTCy	396	73	19.9% (14.7-22.5)	Ref
Haplo-PTCy	1039	203	12.1% (16.3-21.0)	0.98	0.72-1.32	.87
MSD-PTCy	396	73	18.5% (14.7-22.5)	Ref
Haplo: B-leader–matched	627	109	16.5% (13.7-19.5)	0.83	0.6-1.15	.27
Haplo: B-leader–mismatched	412	94	21.8% (17.9-25.9)	1.21	0.86-1.69	.27

Relapse∗	N	Events	Point estimates	HR	95% CI	P
MSD-PTCy	396	155	38.5% (33.5-43.5)	Ref
Haplo-PTCy	1039	379	34.2% (31.3-37.2)	0.87	0.7-1.08	.20
MSD-PTCy	396	155	38.5% (33.5-43.5)	Ref
Haplo: DRB1–mismatched	887	310	32.9% (29.7-36.0)	0.82	0.66-1.02	.07
Haplo: DRB1–matched	152	69	42.1% (34.0-49.9)	1.14	0.85-1.54	.39

Relapse∗	N	Events	Point estimates	HR	95% CI	P
MSD-PTCy	396	155	38.5% (33.5-43.5)	Ref
Haplo-PTCy	1039	379	34.2% (31.3-37.2)	0.87	0.7-1.08	.20
MSD-PTCy	396	155	38.5% (33.5-43.5)	Ref
Haplo: DRB1–mismatched	887	310	32.9% (29.7-36.0)	0.82	0.66-1.02	.07
Haplo: DRB1–matched	152	69	42.1% (34.0-49.9)	1.14	0.85-1.54	.39

Chronic GVHD	N	Events	Point estimates	HR	95% CI	P
MSD-PTCy	399	131	33.6% (28.8-38.5)	Ref
Haplo-PTCy	1035	333	31.7% (28.9-38.5)	0.99	0.73-1.34	.92

Chronic GVHD	N	Events	Point estimates	HR	95% CI	P
MSD-PTCy	399	131	33.6% (28.8-38.5)	Ref
Haplo-PTCy	1035	333	31.7% (28.9-38.5)	0.99	0.73-1.34	.92

Acute GVHD, grade 2-4†	N	Events	Point estimates	HR	95% CI	P
MSD-PTCy	400	129	32.3% (27.7-36.9)	Ref
Haplo-PTCy	1051	326	31.0% (28.3-33.9)	0.95	0.71-1.27	.74

Acute GVHD, grade 2-4†	N	Events	Point estimates	HR	95% CI	P
MSD-PTCy	400	129	32.3% (27.7-36.9)	Ref
Haplo-PTCy	1051	326	31.0% (28.3-33.9)	0.95	0.71-1.27	.74

Full MVA tables are shown in supplemental Table 2.

Haplo, haploidentical; MVA, multivariate analysis; Ref, reference.

Stratified by disease stage.

Stratified by race.