Multivariate analysis: younger haploidentical vs older MSD
| OS . | n . | Events . | Point estimates . | HR . | 95% CI . | P . |
|---|---|---|---|---|---|---|
| Older MSD-PTCy | 143 | 80 | 45.1% (36.5-54.0) | Ref | ||
| Younger haplo-PTCy | 347 | 157 | 57.3 % (52.0-62.5) | 0.76 | 0.57-1.01 | .06 |
| Older MSD-PTCy | 143 | 80 | 45.1% (36.5-54.0) | Ref | ||
| Younger haplo: B-leader–matched | 222 | 91 | 62.1% (55.5-68.4) | 0.65 | 0.48-0.9 | .009 |
| Younger haplo: B-leader–mismatched | 125 | 66 | 48.9% (40.1-57.7) | 0.99 | 0.7-1.39 | .95 |
| OS . | n . | Events . | Point estimates . | HR . | 95% CI . | P . |
|---|---|---|---|---|---|---|
| Older MSD-PTCy | 143 | 80 | 45.1% (36.5-54.0) | Ref | ||
| Younger haplo-PTCy | 347 | 157 | 57.3 % (52.0-62.5) | 0.76 | 0.57-1.01 | .06 |
| Older MSD-PTCy | 143 | 80 | 45.1% (36.5-54.0) | Ref | ||
| Younger haplo: B-leader–matched | 222 | 91 | 62.1% (55.5-68.4) | 0.65 | 0.48-0.9 | .009 |
| Younger haplo: B-leader–mismatched | 125 | 66 | 48.9% (40.1-57.7) | 0.99 | 0.7-1.39 | .95 |
| NRM . | n . | Events . | Point estimates . | HR . | 95% CI . | P . |
|---|---|---|---|---|---|---|
| Older MSD-PTCy | 143 | 34 | 23.7% (16.9-31.1) | Ref | ||
| Younger haplo-PTCy | 340 | 70 | 20.1% (16-24.6) | 0.96 | 0.7-1.33 | .82 |
| Older MSD-PTCy | 143 | 34 | 23.7% (16.9-31.1) | Ref | ||
| Younger haplo: B-leader–matched | 217 | 42 | 19% (14.1-24.5) | 0.87 | 0.61-1.23 | .43 |
| Younger haplo: B-leader–mismatched | 123 | 28 | 22.1% (15.2-29.8) | 1.12 | 0.78-1.6 | .55 |
| NRM . | n . | Events . | Point estimates . | HR . | 95% CI . | P . |
|---|---|---|---|---|---|---|
| Older MSD-PTCy | 143 | 34 | 23.7% (16.9-31.1) | Ref | ||
| Younger haplo-PTCy | 340 | 70 | 20.1% (16-24.6) | 0.96 | 0.7-1.33 | .82 |
| Older MSD-PTCy | 143 | 34 | 23.7% (16.9-31.1) | Ref | ||
| Younger haplo: B-leader–matched | 217 | 42 | 19% (14.1-24.5) | 0.87 | 0.61-1.23 | .43 |
| Younger haplo: B-leader–mismatched | 123 | 28 | 22.1% (15.2-29.8) | 1.12 | 0.78-1.6 | .55 |
| Relapse∗ . | n . | Events . | Point estimates . | HR . | 95% CI . | P . |
|---|---|---|---|---|---|---|
| Older MSD-PTCy | 143 | 65 | 44.7% (36.1-52.9) | Ref | ||
| Younger haplo-PTCy | 340 | 127 | 33.7% (28.7-38.8) | 0.71 | 0.52-0.98 | .04 |
| Older MSD-PTCy | 143 | 65 | 44.7% (36.1-52.9) | Ref | ||
| Younger haplo: DRB1-mismatched | 278 | 93 | 30.6% (25.2-36.1) | 0.63 | 0.46-0.87 | .004 |
| Younger haplo: DRB1-matched | 61 | 34 | 48.3% (34.9-60.4) | 1.03 | 0.68-1.57 | .88 |
| Relapse∗ . | n . | Events . | Point estimates . | HR . | 95% CI . | P . |
|---|---|---|---|---|---|---|
| Older MSD-PTCy | 143 | 65 | 44.7% (36.1-52.9) | Ref | ||
| Younger haplo-PTCy | 340 | 127 | 33.7% (28.7-38.8) | 0.71 | 0.52-0.98 | .04 |
| Older MSD-PTCy | 143 | 65 | 44.7% (36.1-52.9) | Ref | ||
| Younger haplo: DRB1-mismatched | 278 | 93 | 30.6% (25.2-36.1) | 0.63 | 0.46-0.87 | .004 |
| Younger haplo: DRB1-matched | 61 | 34 | 48.3% (34.9-60.4) | 1.03 | 0.68-1.57 | .88 |
| Chronic GVHD . | n . | Events . | Point estimates . | HR . | 95% CI . | P . |
|---|---|---|---|---|---|---|
| Older MSD-PTCy | 142 | 47 | 33.3% (25.4-41.3) | Ref | ||
| Younger haplo-PTCy | 337 | 91 | 26.5% (21.9-31.4) | 0.78 | 0.49-1.25 | .31 |
| Chronic GVHD . | n . | Events . | Point estimates . | HR . | 95% CI . | P . |
|---|---|---|---|---|---|---|
| Older MSD-PTCy | 142 | 47 | 33.3% (25.4-41.3) | Ref | ||
| Younger haplo-PTCy | 337 | 91 | 26.5% (21.9-31.4) | 0.78 | 0.49-1.25 | .31 |
| Acute GVHD, grade 2-4† . | n . | Events . | Point estimates . | HR . | 95% CI . | P . |
|---|---|---|---|---|---|---|
| Older MSD-PTCy | 143 | 44 | 30.8% (23.4-38.5) | Ref | ||
| Younger haplo-PTCy | 347 | 97 | 27.9% (23.4-32.8) | 0.90 | 0.58-1.39 | .64 |
| Acute GVHD, grade 2-4† . | n . | Events . | Point estimates . | HR . | 95% CI . | P . |
|---|---|---|---|---|---|---|
| Older MSD-PTCy | 143 | 44 | 30.8% (23.4-38.5) | Ref | ||
| Younger haplo-PTCy | 347 | 97 | 27.9% (23.4-32.8) | 0.90 | 0.58-1.39 | .64 |