Multivariate analysis showing associations between donor type and clinical outcomes
| OS . | n . | Events . | HR . | 95% CI . | P value . | Overall P . |
|---|---|---|---|---|---|---|
| DP-matched/younger donor | 1586 | 779 | Ref | < .0001 | ||
| DP-matched/older donor | 525 | 296 | 1.17 | 1.02-1.34 | .02 | |
| Permissive-mismatched/younger donor | 3838 | 1835 | 0.93 | 0.85-1.01 | .07 | |
| Permissive-mismatched/older donor | 1181 | 684 | 1.19 | 1.07-1.32 | .001 | |
| Nonpermissive-mismatched/younger donor | 2657 | 1398 | 1.01 | 0.92-1.1 | .83 | |
| Nonpermissive-mismatched/older donor | 975 | 567 | 1.15 | 1.03-1.28 | .01 | |
| Relapse | n | Events | HR | 95% CI | P | |
| DP-matched/younger donor | 1575 | 556 | Ref | .0001 | ||
| DP-matched/older donor | 522 | 200 | 1.13 | 0.96-1.33 | .15 | |
| Permissive-mismatched/younger donor | 3795 | 1239 | 0.88 | 0.79-0.97 | .01 | |
| Permissive-mismatched/older donor | 1173 | 402 | 0.99 | 0.87-1.12 | .87 | |
| Nonpermissive-mismatched/younger donor | 2635 | 824 | 0.83 | 0.75-0.93 | .0009 | |
| Nonpermissive-mismatched/older donor | 965 | 311 | 0.90 | 0.78-1.03 | .14 | |
| NRM | n | Events | HR | 95% CI | P | |
| DP-matched/younger donor | 1583 | 318 | Ref | < .0001 | ||
| DP-matched/older donor | 525 | 128 | 1.24 | 1.01-1.52 | .04 | |
| Permissive-mismatched/younger donor | 3816 | 767 | 0.95 | 0.84-1.08 | .45 | |
| Permissive-mismatched/older donor | 1179 | 332 | 1.40 | 1.2-1.64 | <.0001 | |
| Nonpermissive-mismatched/younger donor | 2647 | 684 | 1.21 | 1.06-1.38 | .004 | |
| Nonpermissive-mismatched/older donor | 970 | 282 | 1.38 | 1.18-1.62 | <.0001 | |
| Acute GVHD, grade 2-4 | n | Events | HR | 95% CI | P | |
| DP-matched/younger donor | 1498 | 546 | Ref | < .0001 | ||
| DP-matched/older donor | 503 | 188 | 1.01 | 0.87-1.19 | .86 | |
| Permissive-mismatched/younger donor | 3691 | 1573 | 1.22 | 1.12-1.34 | <.0001 | |
| Permissive-mismatched/older donor | 1118 | 511 | 1.31 | 1.17-1.47 | <.0001 | |
| Nonpermissive-mismatched/younger donor | 2549 | 1211 | 1.39 | 1.27-1.54 | <.0001 | |
| Nonpermissive-mismatched/older donor | 926 | 484 | 1.53 | 1.36-1.71 | <.0001 | |
| Acute GVHD, grade 3-4 | n | Events | HR | 95% CI | P | |
| DP-matched/younger donor | 1498 | 197 | Ref | .0004 | ||
| DP-matched/older donor | 503 | 73 | 1.06 | 0.82-1.38 | .66 | |
| Permissive-mismatched/younger donor | 3689 | 545 | 1.12 | 0.96-1.32 | .16 | |
| Permissive-mismatched/older donor | 1117 | 194 | 1.31 | 1.08-1.59 | .007 | |
| Nonpermissive-mismatched/younger donor | 2549 | 465 | 1.37 | 1.16-1.62 | <.0001 | |
| Nonpermissive-mismatched/older donor | 926 | 174 | 1.37 | 1.12-1.68 | .002 | |
| Chronic GVHD | n | Events | HR | 95% CI | P | |
| DP-matched/younger donor | 1550 | 766 | Ref | .0004 | ||
| DP-matched/older donor | 517 | 271 | 1.30 | 1.13-1.49 | .0002 | |
| Permissive-mismatched/younger donor | 3738 | 1899 | 1.06 | 0.98-1.15 | .15 | |
| Permissive-mismatched/older donor | 1155 | 575 | 1.18 | 1.06-1.31 | .003 | |
| Nonpermissive-mismatched/younger donor | 2589 | 1330 | 1.14 | 1.05-1.25 | .002 | |
| Nonpermissive-mismatched/older donor | 951 | 467 | 1.16 | 1.04-1.3 | .009 |
| OS . | n . | Events . | HR . | 95% CI . | P value . | Overall P . |
|---|---|---|---|---|---|---|
| DP-matched/younger donor | 1586 | 779 | Ref | < .0001 | ||
| DP-matched/older donor | 525 | 296 | 1.17 | 1.02-1.34 | .02 | |
| Permissive-mismatched/younger donor | 3838 | 1835 | 0.93 | 0.85-1.01 | .07 | |
| Permissive-mismatched/older donor | 1181 | 684 | 1.19 | 1.07-1.32 | .001 | |
| Nonpermissive-mismatched/younger donor | 2657 | 1398 | 1.01 | 0.92-1.1 | .83 | |
| Nonpermissive-mismatched/older donor | 975 | 567 | 1.15 | 1.03-1.28 | .01 | |
| Relapse | n | Events | HR | 95% CI | P | |
| DP-matched/younger donor | 1575 | 556 | Ref | .0001 | ||
| DP-matched/older donor | 522 | 200 | 1.13 | 0.96-1.33 | .15 | |
| Permissive-mismatched/younger donor | 3795 | 1239 | 0.88 | 0.79-0.97 | .01 | |
| Permissive-mismatched/older donor | 1173 | 402 | 0.99 | 0.87-1.12 | .87 | |
| Nonpermissive-mismatched/younger donor | 2635 | 824 | 0.83 | 0.75-0.93 | .0009 | |
| Nonpermissive-mismatched/older donor | 965 | 311 | 0.90 | 0.78-1.03 | .14 | |
| NRM | n | Events | HR | 95% CI | P | |
| DP-matched/younger donor | 1583 | 318 | Ref | < .0001 | ||
| DP-matched/older donor | 525 | 128 | 1.24 | 1.01-1.52 | .04 | |
| Permissive-mismatched/younger donor | 3816 | 767 | 0.95 | 0.84-1.08 | .45 | |
| Permissive-mismatched/older donor | 1179 | 332 | 1.40 | 1.2-1.64 | <.0001 | |
| Nonpermissive-mismatched/younger donor | 2647 | 684 | 1.21 | 1.06-1.38 | .004 | |
| Nonpermissive-mismatched/older donor | 970 | 282 | 1.38 | 1.18-1.62 | <.0001 | |
| Acute GVHD, grade 2-4 | n | Events | HR | 95% CI | P | |
| DP-matched/younger donor | 1498 | 546 | Ref | < .0001 | ||
| DP-matched/older donor | 503 | 188 | 1.01 | 0.87-1.19 | .86 | |
| Permissive-mismatched/younger donor | 3691 | 1573 | 1.22 | 1.12-1.34 | <.0001 | |
| Permissive-mismatched/older donor | 1118 | 511 | 1.31 | 1.17-1.47 | <.0001 | |
| Nonpermissive-mismatched/younger donor | 2549 | 1211 | 1.39 | 1.27-1.54 | <.0001 | |
| Nonpermissive-mismatched/older donor | 926 | 484 | 1.53 | 1.36-1.71 | <.0001 | |
| Acute GVHD, grade 3-4 | n | Events | HR | 95% CI | P | |
| DP-matched/younger donor | 1498 | 197 | Ref | .0004 | ||
| DP-matched/older donor | 503 | 73 | 1.06 | 0.82-1.38 | .66 | |
| Permissive-mismatched/younger donor | 3689 | 545 | 1.12 | 0.96-1.32 | .16 | |
| Permissive-mismatched/older donor | 1117 | 194 | 1.31 | 1.08-1.59 | .007 | |
| Nonpermissive-mismatched/younger donor | 2549 | 465 | 1.37 | 1.16-1.62 | <.0001 | |
| Nonpermissive-mismatched/older donor | 926 | 174 | 1.37 | 1.12-1.68 | .002 | |
| Chronic GVHD | n | Events | HR | 95% CI | P | |
| DP-matched/younger donor | 1550 | 766 | Ref | .0004 | ||
| DP-matched/older donor | 517 | 271 | 1.30 | 1.13-1.49 | .0002 | |
| Permissive-mismatched/younger donor | 3738 | 1899 | 1.06 | 0.98-1.15 | .15 | |
| Permissive-mismatched/older donor | 1155 | 575 | 1.18 | 1.06-1.31 | .003 | |
| Nonpermissive-mismatched/younger donor | 2589 | 1330 | 1.14 | 1.05-1.25 | .002 | |
| Nonpermissive-mismatched/older donor | 951 | 467 | 1.16 | 1.04-1.3 | .009 |
Full models are shown in supplemental Table 3. OS model adjusted for patient age, disease stage, graft/ATG, D/R CMV, KPS, HCT-CI, D/R sex, and year of HCT. Relapse adjusted for patient age, disease stage, graft/ATG, KPS, conditioning intensity, year of HCT, and time to HCT. NRM adjusted for: patient age, disease stage, graft/ATG, GVHD prophylaxis, KPS, HCT-CI, year of HCT, and time to HCT. Grade 2 to 4 acute GVHD adjusted for: disease, disease stage, conditioning intensity, graft/ATG, year of HCT. Grade 3 to 4 Acute GVHD adjusted for: disease, disease stage, conditioning intensity, graft/ATG, D/R CMV and year of HCT. Chronic GVHD adjusted for: patient age, disease stage, graft/ATG, GVHD prophylaxis, KPS, HCT-CI and D/R sex.
ATG, anti-thymocyte glubulin; D/R CMV, donor/recipient cytomegalovirus status; D/R sex, donor/recipient sex; HCT-CI, HCT-specific comorbidity index; IQR, interquartile range; KPS, Karnofsky performance status; Ref, reference group.