Pairwise comparisons
| OS . | . | HR . | 95% CI . | P . |
|---|---|---|---|---|
| Better-matched older donors (ref) vs lesser-matched younger donors | ||||
| DP-matched/older donor (ref) | Permissive-mismatched/younger donor | 0.79 | 0.70-0.89 | .0002 |
| Permissive-mismatched/older donor (ref) | Nonpermissive-mismatched/younger donor | 0.85 | 0.78-0.93 | .0005 |
| DP-matched/older donor (ref) | Nonpermissive-mismatched/younger donor | 0.86 | 0.76-0.98 | .02 |
| Older (ref) vs younger donors within each DP category | ||||
| Permissive-mismatched | 0.78 | 0.71-0.85 | <.0001 | |
| Nonpermissive-mismatched | 0.88 | 0.80-0.97 | .008 | |
| Impact of DP matching within older donor group | ||||
| DP-matched (ref) | Permissive-mismatched | 1.01 | 0.89-1.16 | .83 |
| DP-matched (ref) | Nonpermissive-mismatched | 0.98 | 0.86-1.13 | .83 |
| Permissive-mismatched (ref) | Nonpermissive-mismatched | 0.97 | 0.87-1.08 | .59 |
| Impact of DP matching within younger donor group | ||||
| DP-matched (ref) | Permissive-mismatched | 0.93 | 0.85-1.01 | .07 |
| DP-matched (ref) | Nonpermissive mismatched | 1.01 | 0.92-1.1 | .83 |
| Permissive-mismatched (ref) | Nonpermissive-mismatched | 1.09 | 1.02-1.17 | .02 |
| OS . | . | HR . | 95% CI . | P . |
|---|---|---|---|---|
| Better-matched older donors (ref) vs lesser-matched younger donors | ||||
| DP-matched/older donor (ref) | Permissive-mismatched/younger donor | 0.79 | 0.70-0.89 | .0002 |
| Permissive-mismatched/older donor (ref) | Nonpermissive-mismatched/younger donor | 0.85 | 0.78-0.93 | .0005 |
| DP-matched/older donor (ref) | Nonpermissive-mismatched/younger donor | 0.86 | 0.76-0.98 | .02 |
| Older (ref) vs younger donors within each DP category | ||||
| Permissive-mismatched | 0.78 | 0.71-0.85 | <.0001 | |
| Nonpermissive-mismatched | 0.88 | 0.80-0.97 | .008 | |
| Impact of DP matching within older donor group | ||||
| DP-matched (ref) | Permissive-mismatched | 1.01 | 0.89-1.16 | .83 |
| DP-matched (ref) | Nonpermissive-mismatched | 0.98 | 0.86-1.13 | .83 |
| Permissive-mismatched (ref) | Nonpermissive-mismatched | 0.97 | 0.87-1.08 | .59 |
| Impact of DP matching within younger donor group | ||||
| DP-matched (ref) | Permissive-mismatched | 0.93 | 0.85-1.01 | .07 |
| DP-matched (ref) | Nonpermissive mismatched | 1.01 | 0.92-1.1 | .83 |
| Permissive-mismatched (ref) | Nonpermissive-mismatched | 1.09 | 1.02-1.17 | .02 |
| Relapse . | . | HR . | 95% CI . | P . |
|---|---|---|---|---|
| Better-matched older donors (ref) vs lesser-matched younger donors | ||||
| DP-matched/older donor (ref) | Permissive-mismatched/younger donor | 0.78 | 0.67-0.91 | .001 |
| Permissive-mismatched/older donor (ref) | Nonpermissive-mismatched/younger donor | 0.84 | 0.75-0.95 | .0049 |
| DP-matched/older donor (ref) | Nonpermissive-mismatched/younger donor | 0.74 | 0.63-0.86 | .0002 |
| Older (ref) vs younger donors within each DP category | ||||
| Permissive-mismatched | 0.89 | 0.79-0.99 | .04 | |
| Nonpermissive-mismatched | 0.92 | 0.81-1.05 | .24 | |
| Impact of DP matching within older donor group | ||||
| DP-matched (ref) | Permissive-mismatched | 0.88 | 0.74-1.04 | .14 |
| DP-matched (ref) | Nonpermissive-mismatched | 0.80 | 0.67-0.96 | .02 |
| Permissive-mismatched (ref) | Nonpermissive-mismatched | 0.91 | 0.78-1.06 | .22 |
| Impact of DP matching within younger donor group | ||||
| DP-matched (ref) | Permissive-mismatched | 0.88 | 0.79-0.97 | .01 |
| DP-matched (ref) | Nonpermissive mismatched | 0.83 | 0.75-0.93 | .0009 |
| Permissive-mismatched (ref) | Nonpermissive-mismatched | 0.95 | 0.87-1.04 | .24 |
| Relapse . | . | HR . | 95% CI . | P . |
|---|---|---|---|---|
| Better-matched older donors (ref) vs lesser-matched younger donors | ||||
| DP-matched/older donor (ref) | Permissive-mismatched/younger donor | 0.78 | 0.67-0.91 | .001 |
| Permissive-mismatched/older donor (ref) | Nonpermissive-mismatched/younger donor | 0.84 | 0.75-0.95 | .0049 |
| DP-matched/older donor (ref) | Nonpermissive-mismatched/younger donor | 0.74 | 0.63-0.86 | .0002 |
| Older (ref) vs younger donors within each DP category | ||||
| Permissive-mismatched | 0.89 | 0.79-0.99 | .04 | |
| Nonpermissive-mismatched | 0.92 | 0.81-1.05 | .24 | |
| Impact of DP matching within older donor group | ||||
| DP-matched (ref) | Permissive-mismatched | 0.88 | 0.74-1.04 | .14 |
| DP-matched (ref) | Nonpermissive-mismatched | 0.80 | 0.67-0.96 | .02 |
| Permissive-mismatched (ref) | Nonpermissive-mismatched | 0.91 | 0.78-1.06 | .22 |
| Impact of DP matching within younger donor group | ||||
| DP-matched (ref) | Permissive-mismatched | 0.88 | 0.79-0.97 | .01 |
| DP-matched (ref) | Nonpermissive mismatched | 0.83 | 0.75-0.93 | .0009 |
| Permissive-mismatched (ref) | Nonpermissive-mismatched | 0.95 | 0.87-1.04 | .24 |
| NRM . | . | HR . | 95% CI . | P . |
|---|---|---|---|---|
| Better-matched older donors (ref) vs lesser-matched younger donors | ||||
| DP-matched/older donor (ref) | Permissive-mismatched/younger donor | 0.77 | 0.64-0.93 | .006 |
| Permissive-mismatched/older donor (ref) | Nonpermissive-mismatched/younger donor | 0.86 | 0.76-0.99 | .03 |
| DP-matched/older donor (ref) | Nonpermissive-mismatched/younger donor | 0.98 | 0.81-1.18 | .83 |
| Older (ref) vs younger donors within each DP category | ||||
| Permissive-mismatched | 0.68 | 0.6-0.77 | <.0001 | |
| Nonpermissive-mismatched | 0.88 | 0.76-1.01 | .07 | |
| Impact of DP matching within older donor group | ||||
| DP-matched (ref) | Permissive-mismatched | 1.13 | 0.92-1.39 | .23 |
| DP-matched (ref) | Nonpermissive-mismatched | 1.12 | 0.9-1.38 | .31 |
| Permissive-mismatched (ref) | Nonpermissive-mismatched | 0.98 | 0.84-1.15 | .84 |
| Impact of DP matching within younger donor group | ||||
| DP-matched (ref) | Permissive-mismatched | 0.95 | 0.84-1.08 | .45 |
| DP-matched (ref) | Nonpermissive mismatched | 1.21 | 1.06-1.38 | .004 |
| Permissive-mismatched (ref) | Nonpermissive-mismatched | 1.27 | 1.15-1.41 | <.0001 |
| NRM . | . | HR . | 95% CI . | P . |
|---|---|---|---|---|
| Better-matched older donors (ref) vs lesser-matched younger donors | ||||
| DP-matched/older donor (ref) | Permissive-mismatched/younger donor | 0.77 | 0.64-0.93 | .006 |
| Permissive-mismatched/older donor (ref) | Nonpermissive-mismatched/younger donor | 0.86 | 0.76-0.99 | .03 |
| DP-matched/older donor (ref) | Nonpermissive-mismatched/younger donor | 0.98 | 0.81-1.18 | .83 |
| Older (ref) vs younger donors within each DP category | ||||
| Permissive-mismatched | 0.68 | 0.6-0.77 | <.0001 | |
| Nonpermissive-mismatched | 0.88 | 0.76-1.01 | .07 | |
| Impact of DP matching within older donor group | ||||
| DP-matched (ref) | Permissive-mismatched | 1.13 | 0.92-1.39 | .23 |
| DP-matched (ref) | Nonpermissive-mismatched | 1.12 | 0.9-1.38 | .31 |
| Permissive-mismatched (ref) | Nonpermissive-mismatched | 0.98 | 0.84-1.15 | .84 |
| Impact of DP matching within younger donor group | ||||
| DP-matched (ref) | Permissive-mismatched | 0.95 | 0.84-1.08 | .45 |
| DP-matched (ref) | Nonpermissive mismatched | 1.21 | 1.06-1.38 | .004 |
| Permissive-mismatched (ref) | Nonpermissive-mismatched | 1.27 | 1.15-1.41 | <.0001 |
| Grade 2-4 acute GVHD . | . | HR . | 95% CI . | P . |
|---|---|---|---|---|
| Better-matched older donors (ref) vs lesser-matched younger donors | ||||
| DP-matched/older donor (ref) | Permissive-mismatched/younger donor | 1.21 | 1.04-1.39 | .01 |
| Permissive-mismatched/older donor (ref) | Nonpermissive-mismatched/younger donor | 1.06 | 0.97-1.17 | .21 |
| DP-matched/older donor (ref) | Nonpermissive-mismatched/younger donor | 1.37 | 1.19-1.59 | <.0001 |
| Older (ref) vs younger donors within each DP category | ||||
| Permissive-mismatched | 0.93 | 0.85-1.02 | .15 | |
| Nonpermissive-mismatched | 0.91 | 0.83-1.01 | .07 | |
| Impact of DP matching within older donor group | ||||
| DP-matched (ref) | Permissive-mismatched | 1.29 | 1.1-1.51 | .0015 |
| DP-matched (ref) | Nonpermissive-mismatched | 1.51 | 1.28-1.76 | <.0001 |
| Permissive-mismatched (ref) | Nonpermissive-mismatched | 1.16 | 1.04-1.31 | .009 |
| Impact of DP matching within younger donor group | ||||
| DP-matched (ref) | Permissive-mismatched | 1.22 | 1.12-1.34 | <.0001 |
| DP-matched (ref) | Nonpermissive mismatched | 1.39 | 1.27-1.54 | <.0001 |
| Permissive-mismatched (ref) | Nonpermissive-mismatched | 1.14 | 1.06-1.22 | .0003 |
| Grade 2-4 acute GVHD . | . | HR . | 95% CI . | P . |
|---|---|---|---|---|
| Better-matched older donors (ref) vs lesser-matched younger donors | ||||
| DP-matched/older donor (ref) | Permissive-mismatched/younger donor | 1.21 | 1.04-1.39 | .01 |
| Permissive-mismatched/older donor (ref) | Nonpermissive-mismatched/younger donor | 1.06 | 0.97-1.17 | .21 |
| DP-matched/older donor (ref) | Nonpermissive-mismatched/younger donor | 1.37 | 1.19-1.59 | <.0001 |
| Older (ref) vs younger donors within each DP category | ||||
| Permissive-mismatched | 0.93 | 0.85-1.02 | .15 | |
| Nonpermissive-mismatched | 0.91 | 0.83-1.01 | .07 | |
| Impact of DP matching within older donor group | ||||
| DP-matched (ref) | Permissive-mismatched | 1.29 | 1.1-1.51 | .0015 |
| DP-matched (ref) | Nonpermissive-mismatched | 1.51 | 1.28-1.76 | <.0001 |
| Permissive-mismatched (ref) | Nonpermissive-mismatched | 1.16 | 1.04-1.31 | .009 |
| Impact of DP matching within younger donor group | ||||
| DP-matched (ref) | Permissive-mismatched | 1.22 | 1.12-1.34 | <.0001 |
| DP-matched (ref) | Nonpermissive mismatched | 1.39 | 1.27-1.54 | <.0001 |
| Permissive-mismatched (ref) | Nonpermissive-mismatched | 1.14 | 1.06-1.22 | .0003 |
| Grade 3-4 acute GVHD . | . | HR . | 95% CI . | P . |
|---|---|---|---|---|
| Better-matched older donors (ref) vs lesser-matched younger donors | ||||
| DP-matched/older donor (ref) | Permissive-mismatched/younger donor | 1.06 | 0.83-1.34 | .64 |
| Permissive-mismatched/older donor (ref) | Nonpermissive-mismatched/younger donor | 1.05 | 0.89-1.23 | .58 |
| DP-matched/older donor (ref) | Nonpermissive-mismatched/younger donor | 1.29 | 1.02-1.64 | .035 |
| Older (ref) vs younger donors within each DP category | ||||
| Permissive-mismatched | 0.86 | 0.73-1.01 | .059 | |
| Nonpermissive-mismatched | 1.00 | 0.84-1.18 | .99 | |
| Impact of DP matching within older donor group | ||||
| DP-matched (ref) | Permissive-mismatched | 1.24 | 0.95-1.6 | .11 |
| DP-matched (ref) | Nonpermissive-mismatched | 1.30 | 0.99-1.69 | .06 |
| Permissive-mismatched (ref) | Nonpermissive-mismatched | 1.05 | 0.86-1.28 | .64 |
| Impact of DP matching within younger donor group | ||||
| DP-matched (ref) | Permissive-mismatched | 1.12 | 0.96-1.32 | .16 |
| DP-matched (ref) | Nonpermissive mismatched | 1.37 | 1.12-1.68 | .002 |
| Permissive-mismatched (ref) | Nonpermissive-mismatched | 1.22 | 1.08-1.38 | .0012 |
| Grade 3-4 acute GVHD . | . | HR . | 95% CI . | P . |
|---|---|---|---|---|
| Better-matched older donors (ref) vs lesser-matched younger donors | ||||
| DP-matched/older donor (ref) | Permissive-mismatched/younger donor | 1.06 | 0.83-1.34 | .64 |
| Permissive-mismatched/older donor (ref) | Nonpermissive-mismatched/younger donor | 1.05 | 0.89-1.23 | .58 |
| DP-matched/older donor (ref) | Nonpermissive-mismatched/younger donor | 1.29 | 1.02-1.64 | .035 |
| Older (ref) vs younger donors within each DP category | ||||
| Permissive-mismatched | 0.86 | 0.73-1.01 | .059 | |
| Nonpermissive-mismatched | 1.00 | 0.84-1.18 | .99 | |
| Impact of DP matching within older donor group | ||||
| DP-matched (ref) | Permissive-mismatched | 1.24 | 0.95-1.6 | .11 |
| DP-matched (ref) | Nonpermissive-mismatched | 1.30 | 0.99-1.69 | .06 |
| Permissive-mismatched (ref) | Nonpermissive-mismatched | 1.05 | 0.86-1.28 | .64 |
| Impact of DP matching within younger donor group | ||||
| DP-matched (ref) | Permissive-mismatched | 1.12 | 0.96-1.32 | .16 |
| DP-matched (ref) | Nonpermissive mismatched | 1.37 | 1.12-1.68 | .002 |
| Permissive-mismatched (ref) | Nonpermissive-mismatched | 1.22 | 1.08-1.38 | .0012 |
| Chronic GVHD . | . | HR . | 95% CI . | P . |
|---|---|---|---|---|
| Better-matched older donors (ref) vs lesser-matched younger donors | ||||
| DP-matched/older donor (ref) | Permissive-mismatched/younger donor | 0.82 | 0.72-0.93 | .002 |
| Permissive-mismatched/older donor (ref) | Nonpermissive-mismatched/younger donor | 0.97 | 0.88-1.07 | .58 |
| DP-matched/older donor (ref) | Nonpermissive-mismatched/younger donor | 0.88 | 0.77-1.01 | .06 |
| Older (ref) vs younger donors within each DP category | ||||
| Permissive-mismatched | 0.90 | 0.82-0.99 | .03 | |
| Nonpermissive-mismatched | 0.98 | 0.89-1.09 | .76 | |
| Impact of DP matching within older donor group | ||||
| DP-matched (ref) | Permissive-mismatched | 0.91 | 0.78-1.05 | .19 |
| DP-matched (ref) | Nonpermissive-mismatched | 0.90 | 0.77-1.04 | .16 |
| Permissive-mismatched (ref) | Nonpermissive-mismatched | 0.99 | 0.87-1.12 | .86 |
| Impact of DP matching within younger donor group | ||||
| DP-matched (ref) | Permissive-mismatched | 1.06 | 0.98-1.15 | .15 |
| DP-matched (ref) | Nonpermissive mismatched | 1.14 | 1.05-1.25 | .002 |
| Permissive-mismatched (ref) | Nonpermissive-mismatched | 1.08 | 1.01-1.15 | .04 |
| Chronic GVHD . | . | HR . | 95% CI . | P . |
|---|---|---|---|---|
| Better-matched older donors (ref) vs lesser-matched younger donors | ||||
| DP-matched/older donor (ref) | Permissive-mismatched/younger donor | 0.82 | 0.72-0.93 | .002 |
| Permissive-mismatched/older donor (ref) | Nonpermissive-mismatched/younger donor | 0.97 | 0.88-1.07 | .58 |
| DP-matched/older donor (ref) | Nonpermissive-mismatched/younger donor | 0.88 | 0.77-1.01 | .06 |
| Older (ref) vs younger donors within each DP category | ||||
| Permissive-mismatched | 0.90 | 0.82-0.99 | .03 | |
| Nonpermissive-mismatched | 0.98 | 0.89-1.09 | .76 | |
| Impact of DP matching within older donor group | ||||
| DP-matched (ref) | Permissive-mismatched | 0.91 | 0.78-1.05 | .19 |
| DP-matched (ref) | Nonpermissive-mismatched | 0.90 | 0.77-1.04 | .16 |
| Permissive-mismatched (ref) | Nonpermissive-mismatched | 0.99 | 0.87-1.12 | .86 |
| Impact of DP matching within younger donor group | ||||
| DP-matched (ref) | Permissive-mismatched | 1.06 | 0.98-1.15 | .15 |
| DP-matched (ref) | Nonpermissive mismatched | 1.14 | 1.05-1.25 | .002 |
| Permissive-mismatched (ref) | Nonpermissive-mismatched | 1.08 | 1.01-1.15 | .04 |