LEO cases with major differences between ICC and WHO-HAEM5
| ICC . | WHO-HAEM5 . | Cases, n (%) . | Incidence∗ . |
|---|---|---|---|
| HGBCL with MYC and BCL6 rearrangements | DLBCL, NOS or HGBCL, NOS | 20 (46.5) | <0.1† |
| HCL-v | SBLPN | 11 (25.6) | 0.25 |
| B-PLL‡ | A subset of these cases is incorporated under SBLPN | 7 (16.3) | <0.16 |
| Splenic B-cell lymphoma/leukemia, unclassifiable§ | A subset of these cases is incorporated under SBLPN | 3 (7.0) | <0.15 |
| Testicular follicular lymphoma | Follicular lymphoma | 1 (2.3) | <0.17 |
| Primary DLBCL of the CNS|| | Primary LBCL of the vitreoretinal | 1 (2.3) | <0.18 |
| Total | 43 (100.0) |
| ICC . | WHO-HAEM5 . | Cases, n (%) . | Incidence∗ . |
|---|---|---|---|
| HGBCL with MYC and BCL6 rearrangements | DLBCL, NOS or HGBCL, NOS | 20 (46.5) | <0.1† |
| HCL-v | SBLPN | 11 (25.6) | 0.25 |
| B-PLL‡ | A subset of these cases is incorporated under SBLPN | 7 (16.3) | <0.16 |
| Splenic B-cell lymphoma/leukemia, unclassifiable§ | A subset of these cases is incorporated under SBLPN | 3 (7.0) | <0.15 |
| Testicular follicular lymphoma | Follicular lymphoma | 1 (2.3) | <0.17 |
| Primary DLBCL of the CNS|| | Primary LBCL of the vitreoretinal | 1 (2.3) | <0.18 |
| Total | 43 (100.0) |
B-PLL, B-cell prolymphocytic leukemia; CNS, central nervous system; DLBCL, diffuse large B-cell lymphoma; HCL-v, hairy cell leukemia variant; HGBCL, high-grade B-cell lymphoma; LBCL, large B-cell lymphoma; SBLPN, splenic B-cell lymphoma/leukemia with prominent nucleoli.
Approximate annual US incidence rate per 100 000 population.
Estimated from frequency in LEO cohort and US incidence rate of NHL (https://seer.cancer.gov/statfacts/).
Some cases diagnosed as B-PLL by ICC may not be definitively classifiable in WHO-HAEM5.
Cases not subclassified as HCL-v or splenic diffuse red pulp small B-cell lymphoma.
Only cases of primary DLBCL of the CNS with exclusive vitreoretinal involvement are diagnosed as primary LBCL of the vitreoretina by WHO-HAEM5.