Patient characteristics by aPL status at enrollment
| . | Positive aPL at baseline (n = 116) . | Negative aPL at baseline (n = 408) . | P value . |
|---|---|---|---|
| Median age (IQR), y | 9.8 (1.5-15.8) | 7.6 (0.8-14.9) | .087 |
| Female sex, n (%) | 53 (46) | 192 (47) | .79 |
| White, n (%) | 85 (73) | 294 (72) | .16 |
| Index VTE anatomical site, n (%) | .36 | ||
| Upper or lower extremity | 86 (74) | 312 (77) | |
| Cerebral sinus venous thrombosis | 15 (13) | 60 (15) | |
| Other (splanchnic vein, IVC, or IJ only) | 15 (13) | 35 (9) | |
| VTE-provoking factor, n (%) | |||
| Catheter-associated VTE | 54 (47) | 229 (56) | .068 |
| Infection | 41 (39) | 100 (28) | .019 |
| Autoimmune/inflammatory disease | 3 (3) | 11 (3) | .51 |
| Trauma or surgery | 19 (18) | 72 (20) | .50 |
| Other (dehydration and genetic syndrome) | 12 (11) | 36 (10) | .43 |
| Type of aPL, no. of positive/no. of tested (%) | - | - | |
| LAS-aPTT | 14/29 (40) | — | — |
| Dilute Russell’s viper venom time | 40/43 (93) | — | — |
| STACLOT LA | 38/52 (73) | — | — |
| Anti-cardiolipin IgM | 17/112 (15) | — | — |
| aβ2GP IgG | 16/113 (14) | — | — |
| aβ2GP IgM | 11/113 (10) | — | — |
| . | Positive aPL at baseline (n = 116) . | Negative aPL at baseline (n = 408) . | P value . |
|---|---|---|---|
| Median age (IQR), y | 9.8 (1.5-15.8) | 7.6 (0.8-14.9) | .087 |
| Female sex, n (%) | 53 (46) | 192 (47) | .79 |
| White, n (%) | 85 (73) | 294 (72) | .16 |
| Index VTE anatomical site, n (%) | .36 | ||
| Upper or lower extremity | 86 (74) | 312 (77) | |
| Cerebral sinus venous thrombosis | 15 (13) | 60 (15) | |
| Other (splanchnic vein, IVC, or IJ only) | 15 (13) | 35 (9) | |
| VTE-provoking factor, n (%) | |||
| Catheter-associated VTE | 54 (47) | 229 (56) | .068 |
| Infection | 41 (39) | 100 (28) | .019 |
| Autoimmune/inflammatory disease | 3 (3) | 11 (3) | .51 |
| Trauma or surgery | 19 (18) | 72 (20) | .50 |
| Other (dehydration and genetic syndrome) | 12 (11) | 36 (10) | .43 |
| Type of aPL, no. of positive/no. of tested (%) | - | - | |
| LAS-aPTT | 14/29 (40) | — | — |
| Dilute Russell’s viper venom time | 40/43 (93) | — | — |
| STACLOT LA | 38/52 (73) | — | — |
| Anti-cardiolipin IgM | 17/112 (15) | — | — |
| aβ2GP IgG | 16/113 (14) | — | — |
| aβ2GP IgM | 11/113 (10) | — | — |
aPTT, activated partial thromboplastin time; IJ, internal jugular; IQR, interquartile range; IVC, inferior vena cava; LAS, lupus anticoagulant sensitive.