Bivariate analysis of factors associated with NRM, relapse, and 1-DFS controlling for ATG exposure quadrant (optimal vs nonoptimal)
| Variable and categories . | n . | NRM . | Relapse . | 1-DFS . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| n events . | SHR estimate∗ (95% CI) . | P value . | n events . | SHR estimate∗ (95% CI) . | P value . | n events . | HR estimate† (95% CI) . | P value . | ||
| Age | ||||||||||
| <10 y | 59 | 3 | 1.0 | .055 | 12 | — | — | 15 | — | — |
| ≥10 y | 104 | 15 | 3.38 (0.98-11.71) | 19 | 34 | |||||
| MRD status‡ | ||||||||||
| Negative | 119 | 15 | — | — | 15 | 1.0 | <.001 | 30 | 1.0 | .003 |
| Positive | 39 | 2 | 16 | 4.45 (2.19-9.05) | 18 | 2.45 (1.36-4.41) | ||||
| Donor§ | ||||||||||
| Parent | 107 | 6 | 1.0 | .007 | 25 | — | — | 31 | — | — |
| Full or half sibling | 52 | 12 | 3.89 (1.46-10.38) | 5 | 17 | |||||
| CMV serostatus | ||||||||||
| All others | 137 | 11 | 1.0 | .002 | 23 | 1.0 | .02 | 34 | 1.0 | <.001 |
| R+/D− | 26 | 7 | 4.68 (1.79-12.27) | 8 | 2.62 (1.16-5.91) | 15 | 3.33 (1.8-6.16) | |||
| CD34 dose | ||||||||||
| <15 × 106/kg | 75 | 9 | — | — | 19 | — | — | 28 | 1.0 | .08 |
| ≥15 × 106/kg | 88 | 9 | 12 | 18 | 0.6 (0.34-1.06) | |||||
| Variable and categories . | n . | NRM . | Relapse . | 1-DFS . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| n events . | SHR estimate∗ (95% CI) . | P value . | n events . | SHR estimate∗ (95% CI) . | P value . | n events . | HR estimate† (95% CI) . | P value . | ||
| Age | ||||||||||
| <10 y | 59 | 3 | 1.0 | .055 | 12 | — | — | 15 | — | — |
| ≥10 y | 104 | 15 | 3.38 (0.98-11.71) | 19 | 34 | |||||
| MRD status‡ | ||||||||||
| Negative | 119 | 15 | — | — | 15 | 1.0 | <.001 | 30 | 1.0 | .003 |
| Positive | 39 | 2 | 16 | 4.45 (2.19-9.05) | 18 | 2.45 (1.36-4.41) | ||||
| Donor§ | ||||||||||
| Parent | 107 | 6 | 1.0 | .007 | 25 | — | — | 31 | — | — |
| Full or half sibling | 52 | 12 | 3.89 (1.46-10.38) | 5 | 17 | |||||
| CMV serostatus | ||||||||||
| All others | 137 | 11 | 1.0 | .002 | 23 | 1.0 | .02 | 34 | 1.0 | <.001 |
| R+/D− | 26 | 7 | 4.68 (1.79-12.27) | 8 | 2.62 (1.16-5.91) | 15 | 3.33 (1.8-6.16) | |||
| CD34 dose | ||||||||||
| <15 × 106/kg | 75 | 9 | — | — | 19 | — | — | 28 | 1.0 | .08 |
| ≥15 × 106/kg | 88 | 9 | 12 | 18 | 0.6 (0.34-1.06) | |||||
Boldface values are considered to be statistically significant.
R+/D−, recipient seropositive and donor seronegative.
Determined using Fine-Gray competing risk regression.
Determined using Cox regression proportional hazard models.
Omitted unknown MRD status (n = 4).
Omitted other haploidentical donors (n = 4).