Participant characteristics
| . | Sickle genotype . | P value . | ||
|---|---|---|---|---|
| All (N = 435) . | HbSS/SB0thalassemia (n = 259) . | HbSC/SB+thalassemia /other (n = 176) . | ||
| Demographics and health care use | ||||
| Sex (female) (%) | 225 (52) | 131 (51) | 94 (53) | .63 |
| Mean age, y (SD) | 5.7 (0.8) | 5.7 (0.8) | 5.8 (0.7) | .87 |
| Treatment with hydroxyurea (%) | 120 (28) | 109 (42) | 11 (6) | <.0001∗ |
| Mean duration of Hydroxyurea therapy, y (SD) | 0.7 (1.4) | 1.2 (1.6) | 0.1 (0.6) | <.0001∗ |
| Treatment with chronic transfusion (%) | 39 (9) | 39 (15) | 0 (0) | <.0001∗ |
| Mean no. of all acute care events (hospitalizations and ED visits) per patient-y (SD)† | 0.51 (0.66) | 0.61 (0.66) | 0.36 (0.62) | <.0001∗ |
| Mean no. of ED visits per patient-y (SD)† | 0.24 (0.37) | 0.26 (0.35) | 0.20 (0.41) | .001∗ |
| Mean number of hospitalizations per patient-y (SD)† | 0.30 (0.44) | 0.38 (0.49) | 0.18 (0.34) | <.0001 |
| No treatment (%) | 299 (69) | 134 (52) | 165 (94) | <.0001 |
| Treatment with chronic transfusion only (%) | 16 (4) | 16 (6) | 0 (0) | _ |
| Treatment with hydroxyurea only (%) | 97 (22) | 86 (33) | 11 (6) | _ |
| Treatment with both hydroxyurea and chronic transfusion | 23 (5) | 23 (9) | 0 (0) | _ |
| . | Sickle genotype . | P value . | ||
|---|---|---|---|---|
| All (N = 435) . | HbSS/SB0thalassemia (n = 259) . | HbSC/SB+thalassemia /other (n = 176) . | ||
| Demographics and health care use | ||||
| Sex (female) (%) | 225 (52) | 131 (51) | 94 (53) | .63 |
| Mean age, y (SD) | 5.7 (0.8) | 5.7 (0.8) | 5.8 (0.7) | .87 |
| Treatment with hydroxyurea (%) | 120 (28) | 109 (42) | 11 (6) | <.0001∗ |
| Mean duration of Hydroxyurea therapy, y (SD) | 0.7 (1.4) | 1.2 (1.6) | 0.1 (0.6) | <.0001∗ |
| Treatment with chronic transfusion (%) | 39 (9) | 39 (15) | 0 (0) | <.0001∗ |
| Mean no. of all acute care events (hospitalizations and ED visits) per patient-y (SD)† | 0.51 (0.66) | 0.61 (0.66) | 0.36 (0.62) | <.0001∗ |
| Mean no. of ED visits per patient-y (SD)† | 0.24 (0.37) | 0.26 (0.35) | 0.20 (0.41) | .001∗ |
| Mean number of hospitalizations per patient-y (SD)† | 0.30 (0.44) | 0.38 (0.49) | 0.18 (0.34) | <.0001 |
| No treatment (%) | 299 (69) | 134 (52) | 165 (94) | <.0001 |
| Treatment with chronic transfusion only (%) | 16 (4) | 16 (6) | 0 (0) | _ |
| Treatment with hydroxyurea only (%) | 97 (22) | 86 (33) | 11 (6) | _ |
| Treatment with both hydroxyurea and chronic transfusion | 23 (5) | 23 (9) | 0 (0) | _ |
Participants were aged 1 to 6 years. P value was calculated using Fisher exact test or χ2 test for the categorical variables, and Wilcoxon rank-sum or t test for the continuous variables, respectively.
SD, standard deviation.
False discovery rate–adjusted P values (<.05) or q value (<0.05).
Up to 6 years old.