Table 1. Donor selection criteria to... | American Society of Hematology

Table 1.

Donor selection criteria to enhance the GVL effect

Criteria	HLA-matched unrelated-donor or cord-blood HCT	T cell–depleted haploidentical HCT	T-cell replete haploidentical HCT
NK cell alloreactivity	Not clear⁶^,⁷	Advantage in adult AML and pediatric ALL¹^,²^,⁴	Not clear⁷^,⁸
Mother as donor	N/A	Advantage¹³	Father as donor preferred over mother¹⁴^,⁷³
Activating KIR genes/B haplotypes	Possible advantage¹⁷^,¹⁸	Possible advantage⁴	Not clear⁷⁴

Criteria	HLA-matched unrelated-donor or cord-blood HCT	T cell–depleted haploidentical HCT	T-cell replete haploidentical HCT
NK cell alloreactivity	Not clear⁶^,⁷	Advantage in adult AML and pediatric ALL¹^,²^,⁴	Not clear⁷^,⁸
Mother as donor	N/A	Advantage¹³	Father as donor preferred over mother¹⁴^,⁷³
Activating KIR genes/B haplotypes	Possible advantage¹⁷^,¹⁸	Possible advantage⁴	Not clear⁷⁴

Evidence for the role of some criteria for donor selection that aim to enhance the GVL effect and reduce leukemia relapse.

N/A, not applicable.