Prevalence and impact of inherited thrombophilia on pregnancy associated thrombosis or recurrent pregnancy loss
| Thrombophilia . | Prevalence in the general population (%)8 . | Venous thromboembolism risk in pregnancy (OR, 95% CI)3 . | Risk of recurrent pregnancy loss (OR, 95% CI)6 . |
|---|---|---|---|
| Homozygous factor V Leiden | <1% | 34.4 (9.86-120.05) | 2.76 (1.34-5.71) |
| Heterozygous factor V Leiden | 3.7% | 8.32 (5.44-12.70) | 2.07 (1.57-2.72) |
| Homozygous PGM | <1% | 26.36 (1.24-559.29) | 2.33 (0.87-6.26) |
| Heterozygous PGM | 0.7%-4% | 6.8 (2.46-18.77) | 1.69 (1.17-2.45) |
| Antithrombin deficiency | 0.02% | 4.69 (1.30-16.96) | 0.83 (0.29-2.36) |
| Protein C deficiency | 0.2% | 4.76 (2.15-10.57) | 1.98 (0.97-4.04) |
| Protein S deficiency | 0.03%-0.13% | 3.19 (1.48-6.88) | 3.45 (1.15-10.35) |
| Thrombophilia . | Prevalence in the general population (%)8 . | Venous thromboembolism risk in pregnancy (OR, 95% CI)3 . | Risk of recurrent pregnancy loss (OR, 95% CI)6 . |
|---|---|---|---|
| Homozygous factor V Leiden | <1% | 34.4 (9.86-120.05) | 2.76 (1.34-5.71) |
| Heterozygous factor V Leiden | 3.7% | 8.32 (5.44-12.70) | 2.07 (1.57-2.72) |
| Homozygous PGM | <1% | 26.36 (1.24-559.29) | 2.33 (0.87-6.26) |
| Heterozygous PGM | 0.7%-4% | 6.8 (2.46-18.77) | 1.69 (1.17-2.45) |
| Antithrombin deficiency | 0.02% | 4.69 (1.30-16.96) | 0.83 (0.29-2.36) |
| Protein C deficiency | 0.2% | 4.76 (2.15-10.57) | 1.98 (0.97-4.04) |
| Protein S deficiency | 0.03%-0.13% | 3.19 (1.48-6.88) | 3.45 (1.15-10.35) |