Patient-reported severe symptoms on MDASI-CAR during the 12 months after CAR T-cell therapy
| . | % Severe symptoms on MDASI-CAR (≥7 on a 0-10 scale) . | ||
|---|---|---|---|
| . | ≤30 days after infusion . | 31-90 days after infusion . | >90 days after infusion . |
| MDASI-Core itemsa | |||
| Pain | 21.4 | 15.4 | 5.3 |
| Fatigue | 32.1 | 38.5 | 5.3 |
| Nausea | 7.1 | 0.0 | 0.0 |
| Disturbed sleep | 14.3 | 15.4 | 10.5 |
| Distress | 3.6 | 7.7 | 0.0 |
| Shortness of breath | 3.6 | 7.7 | 5.3 |
| Difficulty remembering | 3.6 | 0.0 | 0.0 |
| Lack of appetite | 14.3 | 30.8 | 0.0 |
| Drowsiness | 17.9 | 38.5 | 10.5 |
| Dry mouth | 21.4 | 23.1 | 0.0 |
| Sadness | 3.6 | 7.7 | 0.0 |
| Vomiting | 0.0 | 7.7 | 0.0 |
| Numbness | 0.0 | 7.7 | 0.0 |
| MDASI-Interference itemsb | |||
| Activity | 25.0 | 15.4 | 10.5 |
| Mood | 7.1 | 7.7 | 10.5 |
| Work | 10.7 | 15.4 | 10.5 |
| Relations with others | 7.1 | 0.0 | 10.5 |
| Walking | 14.3 | 7.7 | 10.5 |
| Enjoyment of life | 14.3 | 15.4 | 10.5 |
| MDASI-CAR Module items (CAR T-cell therapy-related symptoms)a | |||
| Diarrhea | 7.1 | 23.1 | 0.0 |
| Tremors | 3.6 | 0.0 | 0.0 |
| Fever or chills | 7.1 | 0.0 | 0.0 |
| Headache | 10.7 | 15.4 | 0.0 |
| Balance or falling | 7.1 | 7.7 | 0.0 |
| Dizziness | 3.6 | 23.1 | 0.0 |
| Coughing | 3.6 | 15.4 | 5.3 |
| Change in sexual function | 14.3 | 23.1 | 5.3 |
| Problem with paying attention (concentrating) | 3.6 | 23.1 | 0.0 |
| Difficulty speaking (finding the words) | 3.6 | 7.7 | 5.3 |
| . | % Severe symptoms on MDASI-CAR (≥7 on a 0-10 scale) . | ||
|---|---|---|---|
| . | ≤30 days after infusion . | 31-90 days after infusion . | >90 days after infusion . |
| MDASI-Core itemsa | |||
| Pain | 21.4 | 15.4 | 5.3 |
| Fatigue | 32.1 | 38.5 | 5.3 |
| Nausea | 7.1 | 0.0 | 0.0 |
| Disturbed sleep | 14.3 | 15.4 | 10.5 |
| Distress | 3.6 | 7.7 | 0.0 |
| Shortness of breath | 3.6 | 7.7 | 5.3 |
| Difficulty remembering | 3.6 | 0.0 | 0.0 |
| Lack of appetite | 14.3 | 30.8 | 0.0 |
| Drowsiness | 17.9 | 38.5 | 10.5 |
| Dry mouth | 21.4 | 23.1 | 0.0 |
| Sadness | 3.6 | 7.7 | 0.0 |
| Vomiting | 0.0 | 7.7 | 0.0 |
| Numbness | 0.0 | 7.7 | 0.0 |
| MDASI-Interference itemsb | |||
| Activity | 25.0 | 15.4 | 10.5 |
| Mood | 7.1 | 7.7 | 10.5 |
| Work | 10.7 | 15.4 | 10.5 |
| Relations with others | 7.1 | 0.0 | 10.5 |
| Walking | 14.3 | 7.7 | 10.5 |
| Enjoyment of life | 14.3 | 15.4 | 10.5 |
| MDASI-CAR Module items (CAR T-cell therapy-related symptoms)a | |||
| Diarrhea | 7.1 | 23.1 | 0.0 |
| Tremors | 3.6 | 0.0 | 0.0 |
| Fever or chills | 7.1 | 0.0 | 0.0 |
| Headache | 10.7 | 15.4 | 0.0 |
| Balance or falling | 7.1 | 7.7 | 0.0 |
| Dizziness | 3.6 | 23.1 | 0.0 |
| Coughing | 3.6 | 15.4 | 5.3 |
| Change in sexual function | 14.3 | 23.1 | 5.3 |
| Problem with paying attention (concentrating) | 3.6 | 23.1 | 0.0 |
| Difficulty speaking (finding the words) | 3.6 | 7.7 | 5.3 |
Symptom items were rated at their worst in the past 24 hours on a 0 to 10 scale: 0 = no symptom; 10 = as bad as you can imagine.
Interference items were rated at their worst in the past 24 hours on a 0 to 10 scale: 0 = no interference; 10 = interfered completely.
Bold indicates that more than 10% of patients reported the symptom as severe (≥7 on a 0-10 scale).
Modified from Wang et al.12