Definitions for hematologic response in AL amyloidosis
| Response categories . | Definitions . |
|---|---|
| Complete responsea | Negative serum and urine immunofixation electrophoresis and normalization of FLC ratio (or uninvolved FLC concentration greater than involved FLC concentration with or without an abnormal FLC ratio) |
| Very good partial response | If baseline dFLC ≥50 mg/L: reduction in dFLC <40 mg/L |
| Partial response | If baseline dFLC ≥50 mg/L: reduction in dFLC >50% If baseline dFLC 20-50 mg/L: reduction in dFLC <10 mg/L |
| No response | All other patients |
| Response categories . | Definitions . |
|---|---|
| Complete responsea | Negative serum and urine immunofixation electrophoresis and normalization of FLC ratio (or uninvolved FLC concentration greater than involved FLC concentration with or without an abnormal FLC ratio) |
| Very good partial response | If baseline dFLC ≥50 mg/L: reduction in dFLC <40 mg/L |
| Partial response | If baseline dFLC ≥50 mg/L: reduction in dFLC >50% If baseline dFLC 20-50 mg/L: reduction in dFLC <10 mg/L |
| No response | All other patients |
In the ANDROMEDA study,34 a reduction in the absolute involved free light chain level less than or equal to 20 mg/L or a dFLC level less than 10 mg/L were also considered an excellent hematologic response.
Adapted with permission from Kastritis et al.34