Diagnosis and staging of IP-LBCL
| . | PCNSL . | PVRL . | PTL . | IVLBCL . |
|---|---|---|---|---|
| Diagnostic biopsy procedures | ||||
| Stereotactic brain biopsy | Procedure of choice | |||
| Vitreous fluid biopsy | Procedure of choice | |||
| Orchiectomy | Procedure of choice | |||
| Biopsy affected organ (the liver, bone marrow, or skin) | Procedure of choice | |||
| Random skin biopsies | Consider | |||
| Adjunctive tests (CSF or vitreous) | ||||
| Flow cytometry, cytology | Recommended | Recommended | Recommended | Recommended |
| MYD88 mutation testing | Consider | Consider | Consider | Consider |
| Immunoglobulin gene rearrangement | Consider | Consider | Consider | Consider |
| ctDNA | Consider | Consider | Consider | Consider |
| Cytokines (interleukin-6, interleukin-10) | Consider | Consider | Not recommended | Not recommended |
| Laboratory tests | ||||
| Complete blood count, LDH, and liver and renal function | Recommended | Recommended | Recommended | Recommended |
| HIV screening | Recommended | Recommended | Recommended | Recommended |
| Hepatitis B screening | Recommended | Recommended | Recommended | Recommended |
| Hepatitis C screening | Recommended | Recommended | Recommended | Recommended |
| EBV serology | Recommended | Not recommended | Not recommended | Not recommended |
| Staging procedures | ||||
| MRI of brain with gadolinium | Essential | Recommended | Consider | Recommended |
| Dilated eye examination | Recommended | Essential | Not recommended | Not recommended |
| Testicular ultrasound | Consider | Consider | Essential | Not recommended |
| FDG-PET of body | Recommended | Recommended | Recommended | Recommended |
| Peripheral blood flow cytometry | Not recommended | Not recommended | Consider | Consider |
| MRI of spine | Consider | Not recommended | Not recommended | Not Recommended |
| CT of body with contrast | Consider | Consider | Consider | Consider |
| Bone marrow biopsy, aspirate | Consider | Not recommended | Recommended | Recommended |
| . | PCNSL . | PVRL . | PTL . | IVLBCL . |
|---|---|---|---|---|
| Diagnostic biopsy procedures | ||||
| Stereotactic brain biopsy | Procedure of choice | |||
| Vitreous fluid biopsy | Procedure of choice | |||
| Orchiectomy | Procedure of choice | |||
| Biopsy affected organ (the liver, bone marrow, or skin) | Procedure of choice | |||
| Random skin biopsies | Consider | |||
| Adjunctive tests (CSF or vitreous) | ||||
| Flow cytometry, cytology | Recommended | Recommended | Recommended | Recommended |
| MYD88 mutation testing | Consider | Consider | Consider | Consider |
| Immunoglobulin gene rearrangement | Consider | Consider | Consider | Consider |
| ctDNA | Consider | Consider | Consider | Consider |
| Cytokines (interleukin-6, interleukin-10) | Consider | Consider | Not recommended | Not recommended |
| Laboratory tests | ||||
| Complete blood count, LDH, and liver and renal function | Recommended | Recommended | Recommended | Recommended |
| HIV screening | Recommended | Recommended | Recommended | Recommended |
| Hepatitis B screening | Recommended | Recommended | Recommended | Recommended |
| Hepatitis C screening | Recommended | Recommended | Recommended | Recommended |
| EBV serology | Recommended | Not recommended | Not recommended | Not recommended |
| Staging procedures | ||||
| MRI of brain with gadolinium | Essential | Recommended | Consider | Recommended |
| Dilated eye examination | Recommended | Essential | Not recommended | Not recommended |
| Testicular ultrasound | Consider | Consider | Essential | Not recommended |
| FDG-PET of body | Recommended | Recommended | Recommended | Recommended |
| Peripheral blood flow cytometry | Not recommended | Not recommended | Consider | Consider |
| MRI of spine | Consider | Not recommended | Not recommended | Not Recommended |
| CT of body with contrast | Consider | Consider | Consider | Consider |
| Bone marrow biopsy, aspirate | Consider | Not recommended | Recommended | Recommended |
CT, computed tomography EBV, Epstein-Barr virus; LDH, lactate dehydrogenase.