Levels of pro- and anticoagulant proteins in plasma from NIHR BioResource participants
| Protein measured . | Median (IQR) . | Wilcoxon rank sum P value . | |
|---|---|---|---|
| F5-G/G (n = 7) . | F5-ref (n = 13) . | ||
| FV (%) | 101 (93.6-108) | 101 (79.9-121) | .954 (N.S.) |
| Total protein S (%) | 125 (109-141) | 115 (105-139) | .588 (N.S.) |
| Free protein S (%) | 99.0 (81.5-114) | 90.6 (69.3-111) | .548 (N.S.) |
| Total TFPI (nM) | 2.41 (2.16-2.76) | 2.26 (1.88-2.43) | .351 (N.S.) |
| TFPIα (nM) | 0.43 (0.33-0.45) | 0.35 (0.26-0.40) | .119 (N.S.) |
| Protein measured . | Median (IQR) . | Wilcoxon rank sum P value . | |
|---|---|---|---|
| F5-G/G (n = 7) . | F5-ref (n = 13) . | ||
| FV (%) | 101 (93.6-108) | 101 (79.9-121) | .954 (N.S.) |
| Total protein S (%) | 125 (109-141) | 115 (105-139) | .588 (N.S.) |
| Free protein S (%) | 99.0 (81.5-114) | 90.6 (69.3-111) | .548 (N.S.) |
| Total TFPI (nM) | 2.41 (2.16-2.76) | 2.26 (1.88-2.43) | .351 (N.S.) |
| TFPIα (nM) | 0.43 (0.33-0.45) | 0.35 (0.26-0.40) | .119 (N.S.) |
All participants were male, aged 45 to 60 years, of European ancestry, did not smoke, did not have a VTE or bleeding history, and were not taking anticoagulants. All levels are expressed as a percentage of the normal pooled plasma or in nM. Values are shown to 3 significant figures. The values in parentheses next to the median values represent the lower and upper limits of the IQR.
N.S., not significant.