Results from 2-way ANOVA analyses of differences between the 3 VHS groups, pediatric vs adult participants, and interaction effects
| Variable . | 2-way ANOVA . | Post hoc Scheffe test . | |||||
|---|---|---|---|---|---|---|---|
| VHS (F, P value) . | Age group (F, P value) . | VHS: age group (F, P value) . | 0 vs 1 (P value) . | 0 vs 2 (P value) . | 1 vs 2 (P value) . | Peds vs adults (P value) . | |
| Total Hb (g/dL) | (9.334, <.001) | (2.349, .128) | (0.346, .708) | .465 | .001 | .005 | — |
| HbS fraction (%) | (1.367, .259) | (0.544, .462) | (3.472, .034) | — | — | — | — |
| Arterial oxygenation (%) | (0.434, 0.648) | (7.692, 0.006) | (0.339, 0.713) | — | — | — | .019 |
| CaO2 (mL O2/100 mL blood) | (8.746, <.001) | (3.881, .051) | (0.361, .698) | .419 | .002 | .009 | — |
| Gray matter CBF, mean (mL blood/100 g tissue per minute) | (1.138, .323) | (19.382, <.001) | (0.209, .812) | — | — | — | <.001 |
| Gray matter CBF SD (mL blood/100 g tissue per minute) | (3.629, .029) | (52.356, <.001) | (0.150, .861) | .942 | .429 | .085 | <.001 |
| Gray matter CBF sCoV (%) | (4.400, .014) | (12.162, <.001) | (0.079, .924) | .316 | .024 | .260 | <.001 |
| Whole-brain OEF (%) | (11.160, <.001) | (7.665, .006) | (0.019, .982) | .124 | <.001 | .011 | <.001 |
| Whole-brain CMRO2 (mL O2/100 g tissue per minute) | (18.372, <.001) | (26.416, <.001) | (0.230, .795) | .718 | <.001 | <.001 | <.001 |
| Variable . | 2-way ANOVA . | Post hoc Scheffe test . | |||||
|---|---|---|---|---|---|---|---|
| VHS (F, P value) . | Age group (F, P value) . | VHS: age group (F, P value) . | 0 vs 1 (P value) . | 0 vs 2 (P value) . | 1 vs 2 (P value) . | Peds vs adults (P value) . | |
| Total Hb (g/dL) | (9.334, <.001) | (2.349, .128) | (0.346, .708) | .465 | .001 | .005 | — |
| HbS fraction (%) | (1.367, .259) | (0.544, .462) | (3.472, .034) | — | — | — | — |
| Arterial oxygenation (%) | (0.434, 0.648) | (7.692, 0.006) | (0.339, 0.713) | — | — | — | .019 |
| CaO2 (mL O2/100 mL blood) | (8.746, <.001) | (3.881, .051) | (0.361, .698) | .419 | .002 | .009 | — |
| Gray matter CBF, mean (mL blood/100 g tissue per minute) | (1.138, .323) | (19.382, <.001) | (0.209, .812) | — | — | — | <.001 |
| Gray matter CBF SD (mL blood/100 g tissue per minute) | (3.629, .029) | (52.356, <.001) | (0.150, .861) | .942 | .429 | .085 | <.001 |
| Gray matter CBF sCoV (%) | (4.400, .014) | (12.162, <.001) | (0.079, .924) | .316 | .024 | .260 | <.001 |
| Whole-brain OEF (%) | (11.160, <.001) | (7.665, .006) | (0.019, .982) | .124 | <.001 | .011 | <.001 |
| Whole-brain CMRO2 (mL O2/100 g tissue per minute) | (18.372, <.001) | (26.416, <.001) | (0.230, .795) | .718 | <.001 | <.001 | <.001 |
If the variable were significantly different (P < .05) between the VHS group or age group, subsequent Scheffe tests were performed to determine direct pairwise differences between groups for the appropriate factor.
Peds, pediatrics; SD, standard deviation.