Univariable regression analysis: probability of developing cardiac events
| Covariate . | Any cardiac event . | New arrhythmia . | New heart failure . | |||
|---|---|---|---|---|---|---|
| OR (95% CI) . | P value . | OR (95% CI) . | P value . | OR (95% CI) . | P value . | |
| Male sex | 1.69 (0.78-3.63) | .182 | 1.20 (0.44-3.28) | .726 | 1.73 (0.69-4.43) | .248 |
| Age (per 10-y increase) | 1.78 (1.32-2.39) | <.001 | 2.06 (1.31-3.24) | .002 | 1.50 (1.09-2.04) | .011 |
| Age >60 y | 6.37 (2.18-18.6) | .001 | 12.36 (1.61-94.8) | .016 | 3.49 (1.15-10.6) | .028 |
| Total anthracycline dose | 0.99 (0.99-1.01) | .592 | 1.001 (0.995-1.01) | .595 | 0.998 (0.99-1.00) | .576 |
| Modifiable CVR factors | ||||||
| BMI ≥25 | 2.93 (1.23-7.00) | .016 | 3.37 (0.94-12.1) | .062 | 1.91 (0.72-5.06) | .195 |
| eGFR <45 | 1.25 (0.35-4.45) | .729 | _ | .998 | 2.09 (0.57-7.67) | .267 |
| Hypercholesterolaemia | 2.22 (1.03-4.81) | .042 | 3.65 (1.32-10.1) | .013 | 1.36 (0.51-3.66) | .539 |
| Hypertension | 4.57 (2.11-9.92) | <.001 | 6.67 (2.09-21.2) | .001 | 3.56 (1.43-8.90) | .007 |
| Diabetes | 1.55 (0.63-3.82) | .338 | 2.54 (0.84-7.67) | .098 | 1.28 (0.41-3.99) | .667 |
| Smoking history | 0.70 (0.32-1.56) | .702 | 0.41 (0.12-1.47) | .173 | 0.91 (0.36-2.30) | .839 |
| No. of cardiac risk factors | ||||||
| No risk factors | 1 | 1 | 1 | |||
| 1 risk factor | 3.61 (1.13-11.6) | .031 | 2.82 (0.53-14.8) | .222 | 3.12 (0.80-12.1) | .101 |
| ≥2 risk factors | 5.24 (1.69-16.30) | .004 | 5.47 (1.15-25.9) | .033 | 4.06 (1.08-15.2) | .038 |
| Coronary artery calcium score (positive vs negative) | ||||||
| CACS = 0 (n = 202) | 1 | 1 | 1 | |||
| CACS ≥1 (n = 106) | 4.27 (1.97-9.24) | <.001 | 2.60 (0.94-7.19) | .066 | 5.48 (2.06-14.6) | .001 |
| Coronary calcium score (categorized) | ||||||
| CACS = 0 (n = 202) | 1 | 1 | 1 | |||
| CACS 1-400 (n = 73) | 3.66 (1.56-8.60) | .003 | 0.74 (0.21-2.67) | .65 | 2.69 (1.08-6.67) | .033 |
| CACS >400 (n = 33) | 5.50 (2.02-14.9) | .001 | 5.82 (1.96-17.26) | .001 | 3.79 (1.36-10.59) | .011 |
| Covariate . | Any cardiac event . | New arrhythmia . | New heart failure . | |||
|---|---|---|---|---|---|---|
| OR (95% CI) . | P value . | OR (95% CI) . | P value . | OR (95% CI) . | P value . | |
| Male sex | 1.69 (0.78-3.63) | .182 | 1.20 (0.44-3.28) | .726 | 1.73 (0.69-4.43) | .248 |
| Age (per 10-y increase) | 1.78 (1.32-2.39) | <.001 | 2.06 (1.31-3.24) | .002 | 1.50 (1.09-2.04) | .011 |
| Age >60 y | 6.37 (2.18-18.6) | .001 | 12.36 (1.61-94.8) | .016 | 3.49 (1.15-10.6) | .028 |
| Total anthracycline dose | 0.99 (0.99-1.01) | .592 | 1.001 (0.995-1.01) | .595 | 0.998 (0.99-1.00) | .576 |
| Modifiable CVR factors | ||||||
| BMI ≥25 | 2.93 (1.23-7.00) | .016 | 3.37 (0.94-12.1) | .062 | 1.91 (0.72-5.06) | .195 |
| eGFR <45 | 1.25 (0.35-4.45) | .729 | _ | .998 | 2.09 (0.57-7.67) | .267 |
| Hypercholesterolaemia | 2.22 (1.03-4.81) | .042 | 3.65 (1.32-10.1) | .013 | 1.36 (0.51-3.66) | .539 |
| Hypertension | 4.57 (2.11-9.92) | <.001 | 6.67 (2.09-21.2) | .001 | 3.56 (1.43-8.90) | .007 |
| Diabetes | 1.55 (0.63-3.82) | .338 | 2.54 (0.84-7.67) | .098 | 1.28 (0.41-3.99) | .667 |
| Smoking history | 0.70 (0.32-1.56) | .702 | 0.41 (0.12-1.47) | .173 | 0.91 (0.36-2.30) | .839 |
| No. of cardiac risk factors | ||||||
| No risk factors | 1 | 1 | 1 | |||
| 1 risk factor | 3.61 (1.13-11.6) | .031 | 2.82 (0.53-14.8) | .222 | 3.12 (0.80-12.1) | .101 |
| ≥2 risk factors | 5.24 (1.69-16.30) | .004 | 5.47 (1.15-25.9) | .033 | 4.06 (1.08-15.2) | .038 |
| Coronary artery calcium score (positive vs negative) | ||||||
| CACS = 0 (n = 202) | 1 | 1 | 1 | |||
| CACS ≥1 (n = 106) | 4.27 (1.97-9.24) | <.001 | 2.60 (0.94-7.19) | .066 | 5.48 (2.06-14.6) | .001 |
| Coronary calcium score (categorized) | ||||||
| CACS = 0 (n = 202) | 1 | 1 | 1 | |||
| CACS 1-400 (n = 73) | 3.66 (1.56-8.60) | .003 | 0.74 (0.21-2.67) | .65 | 2.69 (1.08-6.67) | .033 |
| CACS >400 (n = 33) | 5.50 (2.02-14.9) | .001 | 5.82 (1.96-17.26) | .001 | 3.79 (1.36-10.59) | .011 |
Values in bold indicate statistically significant P values <0.05.