Univariate and multivariate PFS analysis for fatigue, pain, and QOL at diagnosis
| Variable . | Univariate . | Multivariate . | ||
|---|---|---|---|---|
| HR (95% CI) . | P value . | HR (95% CI) . | P value . | |
| Age | 1.03 (1.02-1.03) | <.001 | 1.02 (1.01-1.03) | <.001 |
| ISS III | 1.6 (1.3-2.0) | <.001 | 1.3 (1.0-1.6) | .06 |
| High-risk FISH∗ | 1.4 (1.1-1.7) | .001 | 1.5 (1.2-1.9) | .002 |
| ASCT after induction | 0.7 (0.6-0.8) | <.001 | 0.9 (0.7-1.2) | .62 |
| Fatigue, ≥5 | 1.5 (1.3-1.8) | <.001 | 1.5 (1.2-1.9) | .001 |
| Pain, ≥5 | 1.2 (1.0-1.4) | .03 | 0.9 (0.7-1.2) | .48 |
| QOL, ≤5 | 1.2 (1.0-1.4) | .04 | 1.1 (0.8-1.4) | .58 |
| Variable . | Univariate . | Multivariate . | ||
|---|---|---|---|---|
| HR (95% CI) . | P value . | HR (95% CI) . | P value . | |
| Age | 1.03 (1.02-1.03) | <.001 | 1.02 (1.01-1.03) | <.001 |
| ISS III | 1.6 (1.3-2.0) | <.001 | 1.3 (1.0-1.6) | .06 |
| High-risk FISH∗ | 1.4 (1.1-1.7) | .001 | 1.5 (1.2-1.9) | .002 |
| ASCT after induction | 0.7 (0.6-0.8) | <.001 | 0.9 (0.7-1.2) | .62 |
| Fatigue, ≥5 | 1.5 (1.3-1.8) | <.001 | 1.5 (1.2-1.9) | .001 |
| Pain, ≥5 | 1.2 (1.0-1.4) | .03 | 0.9 (0.7-1.2) | .48 |
| QOL, ≤5 | 1.2 (1.0-1.4) | .04 | 1.1 (0.8-1.4) | .58 |
HR, hazard ratio.
Defined as presence of t(4;14), t(14;16), t(16;20), del 17p, and/or 1q gain/amplification.