HRs of incident VTE in relation to 1 interquartile range greater estimated concentration of chronic air pollutants: the MESA 2000 to 2018
| Variable . | PM2.5 (per 3.6 μg/m3) . | NO2 (per 13.3 ppb) . | NOx (per 30.0 ppb) . | O3 (per 5.8 ppb) . |
|---|---|---|---|---|
| No. at risk | 6651 | 6651 | 6651 | 6651 |
| VTE, no. | 248 | 246 | 248 | 242 |
| Model 1 HR (95% CI) | 1.43 (1.08-1.91) | 2.87 (1.64-5.01) | 2.30 (1.48-3.57) | 0.76 (0.51-1.13) |
| Model 2 HR (95% CI) | 1.39 (1.04-1.86) | 2.74 (1.57-4.77) | 2.21 (1.42-3.44) | 0.78 (0.52-1.15) |
| Model 3 HR (95% CI)∗ | 1.36 (1.00-1.85) | 2.79 (1.58-4.92) | 2.17 (1.36-3.46) | 0.76 (0.51-1.14) |
| Noncancer VTE, no. | 155 | 155 | 155 | 156 |
| Model 1 HR (95% CI) | 1.63 (1.19-2.24) | 3.32 (1.75-6.28) | 2.46 (1.46-4.13) | 0.69 (0.43-1.12) |
| Model 2 HR (95% CI) | 1.59 (1.15-2.18) | 3.14 (1.65-5.95) | 2.32 (1.37-3.92) | 0.72 (0.44-1.16) |
| Model 3 HR (95% CI)∗ | 1.56 (1.12-2.16) | 2.99 (1.58-5.67) | 2.20 (1.29-3.74) | 0.72 (0.44-1.16) |
| Variable . | PM2.5 (per 3.6 μg/m3) . | NO2 (per 13.3 ppb) . | NOx (per 30.0 ppb) . | O3 (per 5.8 ppb) . |
|---|---|---|---|---|
| No. at risk | 6651 | 6651 | 6651 | 6651 |
| VTE, no. | 248 | 246 | 248 | 242 |
| Model 1 HR (95% CI) | 1.43 (1.08-1.91) | 2.87 (1.64-5.01) | 2.30 (1.48-3.57) | 0.76 (0.51-1.13) |
| Model 2 HR (95% CI) | 1.39 (1.04-1.86) | 2.74 (1.57-4.77) | 2.21 (1.42-3.44) | 0.78 (0.52-1.15) |
| Model 3 HR (95% CI)∗ | 1.36 (1.00-1.85) | 2.79 (1.58-4.92) | 2.17 (1.36-3.46) | 0.76 (0.51-1.14) |
| Noncancer VTE, no. | 155 | 155 | 155 | 156 |
| Model 1 HR (95% CI) | 1.63 (1.19-2.24) | 3.32 (1.75-6.28) | 2.46 (1.46-4.13) | 0.69 (0.43-1.12) |
| Model 2 HR (95% CI) | 1.59 (1.15-2.18) | 3.14 (1.65-5.95) | 2.32 (1.37-3.92) | 0.72 (0.44-1.16) |
| Model 3 HR (95% CI)∗ | 1.56 (1.12-2.16) | 2.99 (1.58-5.67) | 2.20 (1.29-3.74) | 0.72 (0.44-1.16) |
Model 1: Cox regression adjusted for age, sex, race/ethnicity, site, and education.
Model 2: Model 1 + adjustment for smoking status, secondhand smoke exposure, physical activity, and body mass index.
Model 3: Model 2 + adjustment for D-dimer, factor VIII, interleukin-6, C-reactive protein, and fibrinogen.
HR, hazard ratio.
Slight reduction in sample size.