Table 4.

Response outcomes and manner of progression after CAR T-cell therapy

ResponseValue (n = 10)%
Best systemic response   
ORR 8 80 
CR/sCR 6 60 
VGPR 1 10 
PR 1 10 
SD 1 10 
PD 1 10 
Best MRD response   
MRD negative 4 40 
MRD positive 2 20 
Not tested 4 40 
CNS response by day 90   
Yes 10 100 
No 0 0 
Manner of progression after CAR T-cell therapy   
CNS progression∗  4 40 
Systemic progression 8 80 
Manner of identification of progression   
Asymptomatic†  5 50 
Symptomatic 5 50 
ResponseValue (n = 10)%
Best systemic response   
ORR 8 80 
CR/sCR 6 60 
VGPR 1 10 
PR 1 10 
SD 1 10 
PD 1 10 
Best MRD response   
MRD negative 4 40 
MRD positive 2 20 
Not tested 4 40 
CNS response by day 90   
Yes 10 100 
No 0 0 
Manner of progression after CAR T-cell therapy   
CNS progression∗  4 40 
Systemic progression 8 80 
Manner of identification of progression   
Asymptomatic†  5 50 
Symptomatic 5 50 

PD, progressive disease; sCR, stringent complete respo; SD, stable disease; VGPR, very good PR.

∗

Patients who had CNS progression after initial CNS response.

†

Asymptomatic patients for whom progression was identified on routine testing.

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