Sickle cell events of special interest
| Event . | . | Before biologic assignment . | ||
|---|---|---|---|---|
| Patients, n (%) . | . | Events, n (%) . | ||
| Number completing event form | 110 | 57 | ||
| Pulmonary hypertension | 1 (1) | 1 (2) | ||
| Significant cerebrovascular event∗ | 0 (0) | 0 (0) | ||
| Renal function compromise | 2 (2) | 2 (4) | ||
| Avascular necrosis | 4 (4) | 4 (7) | ||
| Leg ulceration | 0 (0) | 0 (0) | ||
| Acute chest syndrome with hospitalization | 6 (5) | 6 (11) | ||
| VOC with hospitalization or parenteral opioid drugs in outpatient setting | 43 (39) | 43 (75) | ||
| Any event leading to advanced care setting or intensive care unit admission/transfer | 1 (1) | 1 (2) | ||
| Event | Year 1 after biologic assignment | |||
| Donor arm | No donor arm | |||
| Patients | Events | Patients | Events | |
| Number who completed event form | 27 | 33 | 77 | 207 |
| Pulmonary hypertension | 0 (0) | 0 (0) | 3 (4) | 4 (2) |
| Significant cerebrovascular event∗ | 4 (15) | 7 (21) | 2 (3) | 3 (1) |
| Renal function compromise | 4 (15) | 6 (18) | 7 (9) | 9 (4) |
| Avascular necrosis | 3 (11) | 3 (9) | 8 (10) | 9 (4) |
| Leg ulceration | 0 (0) | 0 (0) | 1 (1) | 2 (1) |
| Acute chest syndrome with hospitalization | 2 (7) | 2 (6) | 10 (13) | 16 (8) |
| VOC with hospitalization or parenteral opioid drugs in outpatient setting | 9 (33) | 10 (30) | 65 (84) | 159 (77) |
| Any event leading to an advanced care setting or intensive care unit admission/transfer | 3 (11) | 5 (15) | 4 (5) | 5 (2) |
| Event | Year 2 after biologic assignment | |||
| Donor arm | No donor arm | |||
| Patients | Events | Patients | Events | |
| Number completing event form | 21 | 8 | 71 | 183 |
| Pulmonary hypertension | 0 (0) | 0 (0) | 3 (4) | 6 (3) |
| Significant cerebrovascular event∗ | 1 (5) | 1 (12) | 4 (6) | 5 (3) |
| Renal function compromise | 2 (10) | 3 (38) | 5 (7) | 7 (4) |
| Avascular necrosis | 1 (5) | 1 (12) | 5 (7) | 7 (4) |
| Leg ulceration | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| Acute chest syndrome with hospitalization | 0 (0) | 0 (0) | 7 (10) | 9 (5) |
| VOC with hospitalization or parenteral opioid drugs in outpatient setting | 1 (5) | 2 (25) | 59 (83) | 143 (78) |
| Any event leading to an advanced care setting or intensive care unit admission/transfer | 1 (5) | 1 (12) | 5 (7) | 6 (3) |
| Event . | . | Before biologic assignment . | ||
|---|---|---|---|---|
| Patients, n (%) . | . | Events, n (%) . | ||
| Number completing event form | 110 | 57 | ||
| Pulmonary hypertension | 1 (1) | 1 (2) | ||
| Significant cerebrovascular event∗ | 0 (0) | 0 (0) | ||
| Renal function compromise | 2 (2) | 2 (4) | ||
| Avascular necrosis | 4 (4) | 4 (7) | ||
| Leg ulceration | 0 (0) | 0 (0) | ||
| Acute chest syndrome with hospitalization | 6 (5) | 6 (11) | ||
| VOC with hospitalization or parenteral opioid drugs in outpatient setting | 43 (39) | 43 (75) | ||
| Any event leading to advanced care setting or intensive care unit admission/transfer | 1 (1) | 1 (2) | ||
| Event | Year 1 after biologic assignment | |||
| Donor arm | No donor arm | |||
| Patients | Events | Patients | Events | |
| Number who completed event form | 27 | 33 | 77 | 207 |
| Pulmonary hypertension | 0 (0) | 0 (0) | 3 (4) | 4 (2) |
| Significant cerebrovascular event∗ | 4 (15) | 7 (21) | 2 (3) | 3 (1) |
| Renal function compromise | 4 (15) | 6 (18) | 7 (9) | 9 (4) |
| Avascular necrosis | 3 (11) | 3 (9) | 8 (10) | 9 (4) |
| Leg ulceration | 0 (0) | 0 (0) | 1 (1) | 2 (1) |
| Acute chest syndrome with hospitalization | 2 (7) | 2 (6) | 10 (13) | 16 (8) |
| VOC with hospitalization or parenteral opioid drugs in outpatient setting | 9 (33) | 10 (30) | 65 (84) | 159 (77) |
| Any event leading to an advanced care setting or intensive care unit admission/transfer | 3 (11) | 5 (15) | 4 (5) | 5 (2) |
| Event | Year 2 after biologic assignment | |||
| Donor arm | No donor arm | |||
| Patients | Events | Patients | Events | |
| Number completing event form | 21 | 8 | 71 | 183 |
| Pulmonary hypertension | 0 (0) | 0 (0) | 3 (4) | 6 (3) |
| Significant cerebrovascular event∗ | 1 (5) | 1 (12) | 4 (6) | 5 (3) |
| Renal function compromise | 2 (10) | 3 (38) | 5 (7) | 7 (4) |
| Avascular necrosis | 1 (5) | 1 (12) | 5 (7) | 7 (4) |
| Leg ulceration | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
| Acute chest syndrome with hospitalization | 0 (0) | 0 (0) | 7 (10) | 9 (5) |
| VOC with hospitalization or parenteral opioid drugs in outpatient setting | 1 (5) | 2 (25) | 59 (83) | 143 (78) |
| Any event leading to an advanced care setting or intensive care unit admission/transfer | 1 (5) | 1 (12) | 5 (7) | 6 (3) |
Includes stroke, transient ischemic attack, and seizure.