Table 3.

Sickle cell events of special interest

EventBefore biologic assignment
Patients, n (%)Events, n (%)
Number completing event form  110  57 
Pulmonary hypertension  1 (1)  1 (2) 
Significant cerebrovascular event   0 (0)  0 (0) 
Renal function compromise  2 (2)  2 (4) 
Avascular necrosis  4 (4)  4 (7) 
Leg ulceration  0 (0)  0 (0) 
Acute chest syndrome with hospitalization  6 (5)  6 (11) 
VOC with hospitalization or parenteral opioid drugs in outpatient setting  43 (39)  43 (75) 
Any event leading to advanced care setting or intensive care unit admission/transfer  1 (1)  1 (2) 
Event Year 1 after biologic assignment 
Donor arm No donor arm 
Patients Events Patients Events 
Number who completed event form 27 33 77 207 
Pulmonary hypertension 0 (0) 0 (0) 3 (4) 4 (2) 
Significant cerebrovascular event  4 (15) 7 (21) 2 (3) 3 (1) 
Renal function compromise 4 (15) 6 (18) 7 (9) 9 (4) 
Avascular necrosis 3 (11) 3 (9) 8 (10) 9 (4) 
Leg ulceration 0 (0) 0 (0) 1 (1) 2 (1) 
Acute chest syndrome with hospitalization 2 (7) 2 (6) 10 (13) 16 (8) 
VOC with hospitalization or parenteral opioid drugs in outpatient setting 9 (33) 10 (30) 65 (84) 159 (77) 
Any event leading to an advanced care setting or intensive care unit admission/transfer 3 (11) 5 (15) 4 (5) 5 (2) 
Event Year 2 after biologic assignment 
Donor arm No donor arm 
Patients Events Patients Events 
Number completing event form 21 71 183 
Pulmonary hypertension 0 (0) 0 (0) 3 (4) 6 (3) 
Significant cerebrovascular event  1 (5) 1 (12) 4 (6) 5 (3) 
Renal function compromise 2 (10) 3 (38) 5 (7) 7 (4) 
Avascular necrosis 1 (5) 1 (12) 5 (7) 7 (4) 
Leg ulceration 0 (0) 0 (0) 0 (0) 0 (0) 
Acute chest syndrome with hospitalization 0 (0) 0 (0) 7 (10) 9 (5) 
VOC with hospitalization or parenteral opioid drugs in outpatient setting 1 (5) 2 (25) 59 (83) 143 (78) 
Any event leading to an advanced care setting or intensive care unit admission/transfer 1 (5) 1 (12) 5 (7) 6 (3) 
EventBefore biologic assignment
Patients, n (%)Events, n (%)
Number completing event form  110  57 
Pulmonary hypertension  1 (1)  1 (2) 
Significant cerebrovascular event   0 (0)  0 (0) 
Renal function compromise  2 (2)  2 (4) 
Avascular necrosis  4 (4)  4 (7) 
Leg ulceration  0 (0)  0 (0) 
Acute chest syndrome with hospitalization  6 (5)  6 (11) 
VOC with hospitalization or parenteral opioid drugs in outpatient setting  43 (39)  43 (75) 
Any event leading to advanced care setting or intensive care unit admission/transfer  1 (1)  1 (2) 
Event Year 1 after biologic assignment 
Donor arm No donor arm 
Patients Events Patients Events 
Number who completed event form 27 33 77 207 
Pulmonary hypertension 0 (0) 0 (0) 3 (4) 4 (2) 
Significant cerebrovascular event  4 (15) 7 (21) 2 (3) 3 (1) 
Renal function compromise 4 (15) 6 (18) 7 (9) 9 (4) 
Avascular necrosis 3 (11) 3 (9) 8 (10) 9 (4) 
Leg ulceration 0 (0) 0 (0) 1 (1) 2 (1) 
Acute chest syndrome with hospitalization 2 (7) 2 (6) 10 (13) 16 (8) 
VOC with hospitalization or parenteral opioid drugs in outpatient setting 9 (33) 10 (30) 65 (84) 159 (77) 
Any event leading to an advanced care setting or intensive care unit admission/transfer 3 (11) 5 (15) 4 (5) 5 (2) 
Event Year 2 after biologic assignment 
Donor arm No donor arm 
Patients Events Patients Events 
Number completing event form 21 71 183 
Pulmonary hypertension 0 (0) 0 (0) 3 (4) 6 (3) 
Significant cerebrovascular event  1 (5) 1 (12) 4 (6) 5 (3) 
Renal function compromise 2 (10) 3 (38) 5 (7) 7 (4) 
Avascular necrosis 1 (5) 1 (12) 5 (7) 7 (4) 
Leg ulceration 0 (0) 0 (0) 0 (0) 0 (0) 
Acute chest syndrome with hospitalization 0 (0) 0 (0) 7 (10) 9 (5) 
VOC with hospitalization or parenteral opioid drugs in outpatient setting 1 (5) 2 (25) 59 (83) 143 (78) 
Any event leading to an advanced care setting or intensive care unit admission/transfer 1 (5) 1 (12) 5 (7) 6 (3) 

Includes stroke, transient ischemic attack, and seizure.

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