Table 1. Included studies reporting on... | American Society of Hematology

Table 1.

Included studies reporting on the outcome of acute pain episodes

Study	Design	Population	Key findings and clinical descriptions	Description of physical activity/trigger	Diagnosis of SCT	Is description of episode diagnostic of pain/vaso-occlusive episode (as typically observed in SCD)?	Is the reported population representative of the whole experience of the authors (as in a consecutive or random sample)?
Biedrzycki et al²⁰	Case report	A case report of 51-y-old Afro-Caribbean man with SCT	The patient had diabetes and presented acutely with hyperosmolar nonketotic acidosis. He rapidly deteriorated with multiorgan failure after hospital admission. Autopsy demonstrated sickled erythrocytes within the vasculature. The authors also report that the patient had “acute chest syndrome” without any clinical information to support this diagnosis. No prodrome of pain is presented.	Acute illness	History	No	No
Taksande et al¹⁹	Case report	A case report of a single 35-y-old woman with “hemoglobin AS pattern on electrophoresis” from India	The patient reported low back pain for 6 mo while walking with relief in the supine position. Examination revealed pallor, hemoglobin of 6.5 g/dL and MCV of 77 fl. Peripheral smear was consistent with microcytic hypochromic anemia. Peripheral blood smear shows hypochromic microcytic anemia. MRI of the spine showed marrow necrosis in lumbar vertebrae, suggestive of cystic hemorrhagic necrosis of bone, which the authors attribute to sickle cell status.	Not described	Laboratory, electrophoresis	No	No
Dora et al¹⁸	Prospective cohort	119 peripartem females with SCT in India at an academic hospital	The authors report 5 individuals with pain and 1 with “acute chest syndrome” without detailed clinical description of either pain episodes or acute chest syndrome cases.	Pregnancy	Laboratory, HPLC	No	Yes
Souza et al¹⁷	Case-control∗	Cases: 31 individuals with SCT from 2 cities in Brazil Controls: archived frozen samples without SCT	The authors report that 22 of 31 individuals with SCT reported pain in clinical examination. The authors note that pain is in the upper and lower limbs and joints. Beyond this, no other clinical description is provided.	Not described	Laboratory, PCR	No	No

Study	Design	Population	Key findings and clinical descriptions	Description of physical activity/trigger	Diagnosis of SCT	Is description of episode diagnostic of pain/vaso-occlusive episode (as typically observed in SCD)?	Is the reported population representative of the whole experience of the authors (as in a consecutive or random sample)?
Biedrzycki et al²⁰	Case report	A case report of 51-y-old Afro-Caribbean man with SCT	The patient had diabetes and presented acutely with hyperosmolar nonketotic acidosis. He rapidly deteriorated with multiorgan failure after hospital admission. Autopsy demonstrated sickled erythrocytes within the vasculature. The authors also report that the patient had “acute chest syndrome” without any clinical information to support this diagnosis. No prodrome of pain is presented.	Acute illness	History	No	No
Taksande et al¹⁹	Case report	A case report of a single 35-y-old woman with “hemoglobin AS pattern on electrophoresis” from India	The patient reported low back pain for 6 mo while walking with relief in the supine position. Examination revealed pallor, hemoglobin of 6.5 g/dL and MCV of 77 fl. Peripheral smear was consistent with microcytic hypochromic anemia. Peripheral blood smear shows hypochromic microcytic anemia. MRI of the spine showed marrow necrosis in lumbar vertebrae, suggestive of cystic hemorrhagic necrosis of bone, which the authors attribute to sickle cell status.	Not described	Laboratory, electrophoresis	No	No
Dora et al¹⁸	Prospective cohort	119 peripartem females with SCT in India at an academic hospital	The authors report 5 individuals with pain and 1 with “acute chest syndrome” without detailed clinical description of either pain episodes or acute chest syndrome cases.	Pregnancy	Laboratory, HPLC	No	Yes
Souza et al¹⁷	Case-control∗	Cases: 31 individuals with SCT from 2 cities in Brazil Controls: archived frozen samples without SCT	The authors report that 22 of 31 individuals with SCT reported pain in clinical examination. The authors note that pain is in the upper and lower limbs and joints. Beyond this, no other clinical description is provided.	Not described	Laboratory, PCR	No	No

HPLC, high-performance liquid chromatography; MCV, mean corpuscular volume; MRI, magnetic resonance imaging; PCR, polymerase chain reaction.

Pain evaluation not comparative.