Distribution of primary and secondary cytogenetic abnormalities in patients with MM by race/ethnicity
| . | EAs, n (%) . | AAs, n (%) . | P value∗ . |
|---|---|---|---|
| 126 (69.6) | 55 (30.4) | ||
| IMWG HRCA classification† | |||
| Standard risk | 104 (82.5) | 46 (86.8) | .7 |
| High risk | 22 (33.3) | 7 (26.9) | |
| t(4;14)(p16;q32) | |||
| No | 94 (91.3) | 42 (95.5) | .5 |
| Yes | 9 (8.7) | 2 (4.5) | |
| t(11;14)(q13;q32) | |||
| No | 24 (82.8) | 6 (60.0) | .2 |
| Yes | 5 (17.2) | 4 (40.0) | |
| t(14;16)(q32;q23) | |||
| No | 44 (95.7) | 16 (94.1) | 1.0 |
| Yes | 2 (4.3) | 1 (5.9) | |
| t(14;20)(q32;q12) | |||
| No | 36 (100.0) | 16 (94.1) | .3 |
| Yes | 0 (0.0) | 1 (5.9) | |
| Loss of IGH | |||
| No | 49 (72.1) | 16 (61.5) | .3 |
| Yes | 19 (27.9) | 10 (38.5) | |
| IGH rearrangement | |||
| No | 61 (74.4) | 20 (66.7) | .5 |
| Yes | 22 (25.6) | 10 (33.3) | |
| Trisomy of chromosome 3 | |||
| No | 56 (74.7) | 25 (75.8) | 1.0 |
| Yes | 19 (25.3) | 8 (24.2) | |
| Trisomy of chromosome 7 | |||
| No | 48 (80.0) | 14 (70.0) | .4 |
| Yes | 12 (20.0) | 6 (30.0) | |
| Trisomy of chromosome 9 | |||
| No | 51 (64.0) | 20 (58.8) | .7 |
| Yes | 30 (37.0) | 14 (41.2) | |
| Chromosome 13q deletion (del 13q) | |||
| No | 88 (73.3) | 35 (67.3) | .5 |
| Yes | 32 (26.7) | 17 (32.7) | |
| Loss of ATM [11q22.3)] (del 11q) | |||
| No | 107 (98.2) | 42 (100.0) | 1.0 |
| Yes | 2 (1.8) | 0 (0.0) | |
| Gain of ATM | |||
| No | 37 (49.3) | 8 (40.0) | .6 |
| Yes | 38 (50.7) | 12 (60.0) | |
| Loss of TP53 [17p13.1] (del 17p) | |||
| No | 105 (86.1) | 44 (91.7) | .4 |
| Yes | 17 (13.9) | 4 (8.3) | |
| Gain of TP53 | |||
| No | 61 (87.1) | 17 (70.8) | .1 |
| Yes | 9 (12.9) | 7 (29.2) | |
| Loss of CDKN2C [1p32.3] (del 1p) | |||
| No | 71 (97.3) | 30 (90.9) | .2 |
| Yes | 2 (2.7) | 3 (9.1) | |
| Gain/amplification of CKS1B [1q21] (gain/amplification of 1q) | |||
| No | 48 (58.5) | 27 (75.0) | .1 |
| Yes | 34 (41.5) | 9 (25.0) | |
| Tetraploidy | |||
| No | 10 (45.5) | 2 (20.0) | .2 |
| Yes | 12 (54.5) | 8 (80.0) | |
| . | EAs, n (%) . | AAs, n (%) . | P value∗ . |
|---|---|---|---|
| 126 (69.6) | 55 (30.4) | ||
| IMWG HRCA classification† | |||
| Standard risk | 104 (82.5) | 46 (86.8) | .7 |
| High risk | 22 (33.3) | 7 (26.9) | |
| t(4;14)(p16;q32) | |||
| No | 94 (91.3) | 42 (95.5) | .5 |
| Yes | 9 (8.7) | 2 (4.5) | |
| t(11;14)(q13;q32) | |||
| No | 24 (82.8) | 6 (60.0) | .2 |
| Yes | 5 (17.2) | 4 (40.0) | |
| t(14;16)(q32;q23) | |||
| No | 44 (95.7) | 16 (94.1) | 1.0 |
| Yes | 2 (4.3) | 1 (5.9) | |
| t(14;20)(q32;q12) | |||
| No | 36 (100.0) | 16 (94.1) | .3 |
| Yes | 0 (0.0) | 1 (5.9) | |
| Loss of IGH | |||
| No | 49 (72.1) | 16 (61.5) | .3 |
| Yes | 19 (27.9) | 10 (38.5) | |
| IGH rearrangement | |||
| No | 61 (74.4) | 20 (66.7) | .5 |
| Yes | 22 (25.6) | 10 (33.3) | |
| Trisomy of chromosome 3 | |||
| No | 56 (74.7) | 25 (75.8) | 1.0 |
| Yes | 19 (25.3) | 8 (24.2) | |
| Trisomy of chromosome 7 | |||
| No | 48 (80.0) | 14 (70.0) | .4 |
| Yes | 12 (20.0) | 6 (30.0) | |
| Trisomy of chromosome 9 | |||
| No | 51 (64.0) | 20 (58.8) | .7 |
| Yes | 30 (37.0) | 14 (41.2) | |
| Chromosome 13q deletion (del 13q) | |||
| No | 88 (73.3) | 35 (67.3) | .5 |
| Yes | 32 (26.7) | 17 (32.7) | |
| Loss of ATM [11q22.3)] (del 11q) | |||
| No | 107 (98.2) | 42 (100.0) | 1.0 |
| Yes | 2 (1.8) | 0 (0.0) | |
| Gain of ATM | |||
| No | 37 (49.3) | 8 (40.0) | .6 |
| Yes | 38 (50.7) | 12 (60.0) | |
| Loss of TP53 [17p13.1] (del 17p) | |||
| No | 105 (86.1) | 44 (91.7) | .4 |
| Yes | 17 (13.9) | 4 (8.3) | |
| Gain of TP53 | |||
| No | 61 (87.1) | 17 (70.8) | .1 |
| Yes | 9 (12.9) | 7 (29.2) | |
| Loss of CDKN2C [1p32.3] (del 1p) | |||
| No | 71 (97.3) | 30 (90.9) | .2 |
| Yes | 2 (2.7) | 3 (9.1) | |
| Gain/amplification of CKS1B [1q21] (gain/amplification of 1q) | |||
| No | 48 (58.5) | 27 (75.0) | .1 |
| Yes | 34 (41.5) | 9 (25.0) | |
| Tetraploidy | |||
| No | 10 (45.5) | 2 (20.0) | .2 |
| Yes | 12 (54.5) | 8 (80.0) | |
P values of the Fisher exact test.
IMWG molecular classification of MM: High-risk MM was defined by the presence of any HRCAs, including t(4;14), t(14;16), t(14;20), del 17p, and gain/amplification of 1q 19. Standard-risk MM was defined by the absence of HRCAs or the presence of any trisomies of odd-numbered chromosomes or t(11;14).