PTEN, PI3K3A, PI3R1, AKT1 status, and phospho-AKT levels in 8 PDXs that underwent metabolomic analysis
| PDX . | PTEN . | PIK3CA . | PIK3R1 . | AKT1 . | pAKT levels (geo mean from FACS analysis) . |
|---|---|---|---|---|---|
| UPN 663 | p.R233WA biallelic | GL | GL | GL | 15,1 |
| UPN 534 | Type I monoallelic deletion | GL | GL | GL | 14,7 |
| UPN 374 | GL | c.1624G>A biallelic | GL | GL | 19,4 |
| UPN 519 | p.R233SfsX14 biallelic | GL | GL | GL | 24,5 |
| UPN 584 | GL | GL | GL | GL | 0 |
| UPN 567 | GL | GL | GL | GL | 0 |
| UPN 613 | GL | GL | GL | GL | 934 |
| UPN 610 | GL | GL | GL | GL | 1,7 |
| PDX . | PTEN . | PIK3CA . | PIK3R1 . | AKT1 . | pAKT levels (geo mean from FACS analysis) . |
|---|---|---|---|---|---|
| UPN 663 | p.R233WA biallelic | GL | GL | GL | 15,1 |
| UPN 534 | Type I monoallelic deletion | GL | GL | GL | 14,7 |
| UPN 374 | GL | c.1624G>A biallelic | GL | GL | 19,4 |
| UPN 519 | p.R233SfsX14 biallelic | GL | GL | GL | 24,5 |
| UPN 584 | GL | GL | GL | GL | 0 |
| UPN 567 | GL | GL | GL | GL | 0 |
| UPN 613 | GL | GL | GL | GL | 934 |
| UPN 610 | GL | GL | GL | GL | 1,7 |
FACS, fluorescence activted cell sorting; GL, germ line; pAKT, phosphorylated AKT; phospho, phosphorylated.