Summary of functional interactions between cyclin D1 and DNA damage proteins
| DDR protein . | Functional link with cyclin D1 . | References . |
|---|---|---|
| RAD51 | Cyclin D1 tethered to chromatin → recruits RAD51 recombinase → HR | 24,25 |
| BRCA1 | Cyclin D1–CDK4 kinase phosphorylates BRCA1 (Ser632) → BRCA1 not recruited to target promoters Cyclin D1 competes with BRCA1 for ERα binding → reduced BRCA1-mediated repression of ERα transcriptional activity | 26 27 |
| BRCA2 | Physical interaction of cyclin D1/BRCA2/RAD51 with Sp1 transcription factor → complexes with γH2AX and members of the MRN complex → DSB repair | 28 |
| PCNA | Physical interaction between cyclin D1 and PCNA → interaction with BRCA1 during UV-induced DNA damage repair | 29 |
| RFC | Physical interaction between cyclin D1 and RFC → interaction with BRCA1 during UV-induced DNA damage repair | 29 |
| DDR protein . | Functional link with cyclin D1 . | References . |
|---|---|---|
| RAD51 | Cyclin D1 tethered to chromatin → recruits RAD51 recombinase → HR | 24,25 |
| BRCA1 | Cyclin D1–CDK4 kinase phosphorylates BRCA1 (Ser632) → BRCA1 not recruited to target promoters Cyclin D1 competes with BRCA1 for ERα binding → reduced BRCA1-mediated repression of ERα transcriptional activity | 26 27 |
| BRCA2 | Physical interaction of cyclin D1/BRCA2/RAD51 with Sp1 transcription factor → complexes with γH2AX and members of the MRN complex → DSB repair | 28 |
| PCNA | Physical interaction between cyclin D1 and PCNA → interaction with BRCA1 during UV-induced DNA damage repair | 29 |
| RFC | Physical interaction between cyclin D1 and RFC → interaction with BRCA1 during UV-induced DNA damage repair | 29 |
ERα, estrogen receptor α; MRN, Mre11, Rad50, and Nbs1; PCNA, proliferating cell nuclear antigen; RFC, replication factor C.