Amino acid substitutions made in FXII
| FN2 . | KNG . | Act loop . | CD . |
|---|---|---|---|
| FXII-Arg36Ala | FXII-Glu225Ala | FXII-Arg343Ala | FXII-Val359Ala |
| FXII-Lys41Ala | FXII-Asn230Ala | FXII-Arg345Ala | FXII-Arg362Ala |
| FXII-Lys45Ala | FXII-Asp253Lys | FXII-Lys346Ala | FXII-Glu411Ala |
| FXII-Arg47Ala | FXII-Asp264Ala | FXII-Gln501Ala | |
| FXII-Arg265Ala | FXII-Glu502Ala | ||
| FXII-Leu266Ala | FXII-Glu551Ala | ||
| FXII-Trp268Ala |
| FN2 . | KNG . | Act loop . | CD . |
|---|---|---|---|
| FXII-Arg36Ala | FXII-Glu225Ala | FXII-Arg343Ala | FXII-Val359Ala |
| FXII-Lys41Ala | FXII-Asn230Ala | FXII-Arg345Ala | FXII-Arg362Ala |
| FXII-Lys45Ala | FXII-Asp253Lys | FXII-Lys346Ala | FXII-Glu411Ala |
| FXII-Arg47Ala | FXII-Asp264Ala | FXII-Gln501Ala | |
| FXII-Arg265Ala | FXII-Glu502Ala | ||
| FXII-Leu266Ala | FXII-Glu551Ala | ||
| FXII-Trp268Ala |
Act loop, activation loop.