Demographics and baseline characteristics of confirmed CD cases
| . | iMCD n = 119 . | CD-undefined n = 14 . | UCD n = 46 . |
|---|---|---|---|
| Age, mean (SD), y | 36.0 (15.8) | 34.0 (16.1) | 41.4 (12.5) |
| <18, n (%) | 21 (18.1) | 2 (14.3) | 2 (4.3) |
| Deceased, n (%) | 9 (7.6) | 0 | 1 (2.2) |
| Sex, n (%) | |||
| Female | 60 (50.4) | 10 (71.4) | 31 (67.4) |
| Male | 59 (49.6) | 4 (28.6) | 15 (32.6) |
| Race, n (%) | |||
| American Indian/Alaska Native | 1 (0.8) | 0 | 0 |
| Asian | 14 (11.8) | 0 | 2 (4.3) |
| Black | 12 (10.1) | 0 | 1 (2.2) |
| Native Hawaiian/Pacific Islander | 1 (0.8) | 0 | 0 |
| White | 80 (67.2) | 14 (100) | 42 (91.3) |
| Not provided | 11 (9.2) | 0 | 1 (2.2) |
| Histopathological subtype, n (%) | |||
| Hyaline vascular/hypervascular | 80 (67.2) | 11 (78.6) | 40 (87) |
| Mixed | 31 (26.1) | 3 (21.4) | 6 (13) |
| Plasmacytic | 8 (6.7) | 0 | 0 |
| Assessed number of minor criteria, median (IQR) | 11 (10-11) | 7 (6.3-10) | 9 (8-10) |
| Abnormal number of minor criteria, median (IQR) | 7 (5-8) | 1 (0-1) | 2 (1-3) |
| Inflammatory syndrome,∗ n (%) | |||
| Present | 84 (82.3) | 0 | 7 (25.9) |
| Absent | 18 (17.6) | 7 (100) | 20 (74.1) |
| Insufficient informatoin | 17 | 7 | 19 |
| No. of enlarged node stations, median (IQR) | 8.0 (5.0-10.5) | 3.0 (2.0-4.0) | 1.0 (1.0-1.0) |
| Follow-up time, median (IQR), y | 2.9 (1.2-5.2) | 2.7 (1.1-5.7) | 1.3 (0.4-4.3) |
| . | iMCD n = 119 . | CD-undefined n = 14 . | UCD n = 46 . |
|---|---|---|---|
| Age, mean (SD), y | 36.0 (15.8) | 34.0 (16.1) | 41.4 (12.5) |
| <18, n (%) | 21 (18.1) | 2 (14.3) | 2 (4.3) |
| Deceased, n (%) | 9 (7.6) | 0 | 1 (2.2) |
| Sex, n (%) | |||
| Female | 60 (50.4) | 10 (71.4) | 31 (67.4) |
| Male | 59 (49.6) | 4 (28.6) | 15 (32.6) |
| Race, n (%) | |||
| American Indian/Alaska Native | 1 (0.8) | 0 | 0 |
| Asian | 14 (11.8) | 0 | 2 (4.3) |
| Black | 12 (10.1) | 0 | 1 (2.2) |
| Native Hawaiian/Pacific Islander | 1 (0.8) | 0 | 0 |
| White | 80 (67.2) | 14 (100) | 42 (91.3) |
| Not provided | 11 (9.2) | 0 | 1 (2.2) |
| Histopathological subtype, n (%) | |||
| Hyaline vascular/hypervascular | 80 (67.2) | 11 (78.6) | 40 (87) |
| Mixed | 31 (26.1) | 3 (21.4) | 6 (13) |
| Plasmacytic | 8 (6.7) | 0 | 0 |
| Assessed number of minor criteria, median (IQR) | 11 (10-11) | 7 (6.3-10) | 9 (8-10) |
| Abnormal number of minor criteria, median (IQR) | 7 (5-8) | 1 (0-1) | 2 (1-3) |
| Inflammatory syndrome,∗ n (%) | |||
| Present | 84 (82.3) | 0 | 7 (25.9) |
| Absent | 18 (17.6) | 7 (100) | 20 (74.1) |
| Insufficient informatoin | 17 | 7 | 19 |
| No. of enlarged node stations, median (IQR) | 8.0 (5.0-10.5) | 3.0 (2.0-4.0) | 1.0 (1.0-1.0) |
| Follow-up time, median (IQR), y | 2.9 (1.2-5.2) | 2.7 (1.1-5.7) | 1.3 (0.4-4.3) |
ESR, erythrocyte sedimentation rate; SD, standard deviation.
Inflammatory syndrome was defined as at least 2 of 3 parameters occurring simultaneously within at least 90 days of diagnosis: anemia, hypoalbuminemia, and inflammation, defined as hemoglobin of <11.5 g/dL (males) or <10.5 g/dL (females), albumin of <3.5 g/dL, and either CRP of >20 mg/dL or ESR of >30 mm/h, respectively. Insufficient information reflects cases for which hemoglobin, albumin, and CRP/ESR were not measured or were not measured concurrently and therefore there was not sufficient information to assign inflammatory syndrome.