Table 2.

Comparative molecular analysis of primary and secondary MH

Alterations in the MAPK pathwayPTPN11 mutationsTP53 mutationMutations in TET2, ASXL1 or DNMT3A
Total n = 50/71 (m.d.: 67) (70%) n = 10/64 (m.d.: 74) (16%) n = 9/63 (m.d.: 75) (14%) n = 13/63 (m.d.: 75) (21%) 
Primary MH n = 22/40 (m.d.: 49) (55%) n = 10/37 (m.d.: 52) (27%) n = 3/36 (m.d.: 53) (8%) n = 7/36 (m.d.: 53) (19%) 
Secondary MH n = 28/31 (m.d.: 18) (90%) n = 0/27 (m.d.: 22) (0%) n = 6/27 (m.d.: 22) (22%) n = 6/27 (m.d.: 22) (22%) 
P value 0.0012 (χ2 test) 0.0035 (Fisher exact test) 0.1550 (Fisher exact test) 0.7875 (χ2 test) 
Alterations in the MAPK pathwayPTPN11 mutationsTP53 mutationMutations in TET2, ASXL1 or DNMT3A
Total n = 50/71 (m.d.: 67) (70%) n = 10/64 (m.d.: 74) (16%) n = 9/63 (m.d.: 75) (14%) n = 13/63 (m.d.: 75) (21%) 
Primary MH n = 22/40 (m.d.: 49) (55%) n = 10/37 (m.d.: 52) (27%) n = 3/36 (m.d.: 53) (8%) n = 7/36 (m.d.: 53) (19%) 
Secondary MH n = 28/31 (m.d.: 18) (90%) n = 0/27 (m.d.: 22) (0%) n = 6/27 (m.d.: 22) (22%) n = 6/27 (m.d.: 22) (22%) 
P value 0.0012 (χ2 test) 0.0035 (Fisher exact test) 0.1550 (Fisher exact test) 0.7875 (χ2 test) 

m.d., missing data.

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