Characteristics by TP53 mutation VAF levels
| Variable . | n (%) N = 240 . | VAF max, n (%) . | P value . | |
|---|---|---|---|---|
| <50 N = 175 . | ≥50 N = 49 . | |||
| Diagnosis | ||||
| MDS | 114 (47) | 85 (49) | 24 (49) | .9 |
| AML | 126 (53) | 90 (51) | 25 (51) | |
| Therapy-related AML | ||||
| Yes | 40 (32) | 28 (31) | 9 (36) | .6 |
| No | 86 (68) | 62 (69) | 16 (64) | |
| Cytogenetics | ||||
| Complex | 171 (72) | 114 (65) | 42 (86) | |
| 5q/7q | 18 (7) | 17 (10) | 1 (2) | |
| Other | 44 (18) | 39 (22) | 4 (8) | |
| Missing | 7 (3) | 5 (3) | 2 (4) | .001 |
| TP53 allele status | ||||
| Monohit | 66 (27) | 66 (38) | 0 | |
| Multihit | 166 (70) | 107 (61) | 49 (100) | |
| Missing | 8 (3) | 2 (1) | 0 | <.001 |
| EA score | ||||
| ≥52 | 212 (88) | 155 (88) | 41 (84) | |
| <52 | 19 (8) | 12 (7) | 7 (14) | |
| Unknown | 9 (4) | 8 (5) | 1 (2) | .2 |
| TP53 detected at transplant by NGS | ||||
| Yes | 46 (49) | 35 (50) | 10 (62) | |
| No | 22 (23) | 17 (25) | 4 (25) | |
| N/A | 26 (28) | 17 (25) | 2 (13) | .5 |
| Number of TP53 mutations | ||||
| 1 | 169 (70) | 114 (65) | 39 (80) | |
| 2 | 57 (24) | 49 (28) | 8 (16) | |
| >2 | 14 (6) | 12 (7) | 2 (4) | .05 |
| Truncated mutations | ||||
| Yes | 39 (16) | 28 (16) | 5 (10) | |
| No | 201 (84) | 142 (84) | 44 (90) | .3 |
| MRD by MCF at transplant | ||||
| Yes | 105 (44) | 69 (40) | 27 (55) | |
| No | 73 (30) | 53 (30) | 13 (27) | |
| ND/unknown | 62 (26) | 53 (30) | 9 (18) | .2 |
| Disease status at dx CR1 or 2 vs all other | 93 (39) | 68 (39) | 16 (33) | .4 |
| Prior disease directed treatment, >1 line of treatment | 75 (31) | 51 (29) | 16 (33) | .6 |
| Variable . | n (%) N = 240 . | VAF max, n (%) . | P value . | |
|---|---|---|---|---|
| <50 N = 175 . | ≥50 N = 49 . | |||
| Diagnosis | ||||
| MDS | 114 (47) | 85 (49) | 24 (49) | .9 |
| AML | 126 (53) | 90 (51) | 25 (51) | |
| Therapy-related AML | ||||
| Yes | 40 (32) | 28 (31) | 9 (36) | .6 |
| No | 86 (68) | 62 (69) | 16 (64) | |
| Cytogenetics | ||||
| Complex | 171 (72) | 114 (65) | 42 (86) | |
| 5q/7q | 18 (7) | 17 (10) | 1 (2) | |
| Other | 44 (18) | 39 (22) | 4 (8) | |
| Missing | 7 (3) | 5 (3) | 2 (4) | .001 |
| TP53 allele status | ||||
| Monohit | 66 (27) | 66 (38) | 0 | |
| Multihit | 166 (70) | 107 (61) | 49 (100) | |
| Missing | 8 (3) | 2 (1) | 0 | <.001 |
| EA score | ||||
| ≥52 | 212 (88) | 155 (88) | 41 (84) | |
| <52 | 19 (8) | 12 (7) | 7 (14) | |
| Unknown | 9 (4) | 8 (5) | 1 (2) | .2 |
| TP53 detected at transplant by NGS | ||||
| Yes | 46 (49) | 35 (50) | 10 (62) | |
| No | 22 (23) | 17 (25) | 4 (25) | |
| N/A | 26 (28) | 17 (25) | 2 (13) | .5 |
| Number of TP53 mutations | ||||
| 1 | 169 (70) | 114 (65) | 39 (80) | |
| 2 | 57 (24) | 49 (28) | 8 (16) | |
| >2 | 14 (6) | 12 (7) | 2 (4) | .05 |
| Truncated mutations | ||||
| Yes | 39 (16) | 28 (16) | 5 (10) | |
| No | 201 (84) | 142 (84) | 44 (90) | .3 |
| MRD by MCF at transplant | ||||
| Yes | 105 (44) | 69 (40) | 27 (55) | |
| No | 73 (30) | 53 (30) | 13 (27) | |
| ND/unknown | 62 (26) | 53 (30) | 9 (18) | .2 |
| Disease status at dx CR1 or 2 vs all other | 93 (39) | 68 (39) | 16 (33) | .4 |
| Prior disease directed treatment, >1 line of treatment | 75 (31) | 51 (29) | 16 (33) | .6 |
MCF, multicolor flow cytometry; MRD, measurable residual disease; N/A, non-applicable; ND, not done.