Complete list of analyzed genes and their mechanisms of action
| Mechanism of action . | Implicated gene(s) . |
|---|---|
| JAK/STAT signaling | TPO, JAK1/2/3, TYK2, PI3K, KRAS, NRAS, RAF1, STAT1/3/5, SOCS1, LNK, PRMT5, MEP50, SHC, GRB2, SOS1, MAPK1/3 |
| Treg, TGF-β signaling | IFNA17, SMAD2 |
| IL-17 induction | DGCR14 |
| Th17/Treg balance | CD83 |
| Class II cytokine receptor | IFNLR1 |
| T- and B-cell function, inflammation | REL |
| Fcγ receptors | FCGR2A, FCGR2B, FCGR2C, FCGR3A, FCGR3B |
| Treg, cytokine related immune responses | CXCL5, CCL5, EGFR, CD40L, CNR2 |
| T-cell immune regulation | CTLA4, CD28, ICOS, PD1, BTLA, TIGIT, CD80, CD86 |
| Actin regulators | VAV1, CFL1, RLTPR, RCSD1 |
| Apoptosis | TNFA, PRKACA, PRKACB, PRKACG, LTA, IFNG, DNMT3B, TBX21 |
| B-cell receptor | TNFRSF13B, SOX13, PTPN22 |
| Transcriptional factors | MPL, RUNX1, TAL1, MLL, GFI1, TEL, BMI1, GATA1, GATA2, LMO2, NFE2, FOG1, NFKB1, NFKB2, FOS, JUN, SMAD7, TNFAIP3, VEGFR, FLI1, SDF1 |
| Early acting hematopoietic growth factors | SCF, IL1A, IL2, IL3, IL4, IL6, IL10, IL11, IL17A, IL17B, IL17C, IL18, IL21, IL22, MTOR, PRKAA2 |
| Cytoskeleton and structural proteins | ACTN1, TUBB1, WAS, MYH9, FLNA, ANKRD26, ABCA1, FERMT3, MASTL, PRKACG, ABCG5 |
| Complement system | C1QBP, CPB2 |
| Mechanism of action . | Implicated gene(s) . |
|---|---|
| JAK/STAT signaling | TPO, JAK1/2/3, TYK2, PI3K, KRAS, NRAS, RAF1, STAT1/3/5, SOCS1, LNK, PRMT5, MEP50, SHC, GRB2, SOS1, MAPK1/3 |
| Treg, TGF-β signaling | IFNA17, SMAD2 |
| IL-17 induction | DGCR14 |
| Th17/Treg balance | CD83 |
| Class II cytokine receptor | IFNLR1 |
| T- and B-cell function, inflammation | REL |
| Fcγ receptors | FCGR2A, FCGR2B, FCGR2C, FCGR3A, FCGR3B |
| Treg, cytokine related immune responses | CXCL5, CCL5, EGFR, CD40L, CNR2 |
| T-cell immune regulation | CTLA4, CD28, ICOS, PD1, BTLA, TIGIT, CD80, CD86 |
| Actin regulators | VAV1, CFL1, RLTPR, RCSD1 |
| Apoptosis | TNFA, PRKACA, PRKACB, PRKACG, LTA, IFNG, DNMT3B, TBX21 |
| B-cell receptor | TNFRSF13B, SOX13, PTPN22 |
| Transcriptional factors | MPL, RUNX1, TAL1, MLL, GFI1, TEL, BMI1, GATA1, GATA2, LMO2, NFE2, FOG1, NFKB1, NFKB2, FOS, JUN, SMAD7, TNFAIP3, VEGFR, FLI1, SDF1 |
| Early acting hematopoietic growth factors | SCF, IL1A, IL2, IL3, IL4, IL6, IL10, IL11, IL17A, IL17B, IL17C, IL18, IL21, IL22, MTOR, PRKAA2 |
| Cytoskeleton and structural proteins | ACTN1, TUBB1, WAS, MYH9, FLNA, ANKRD26, ABCA1, FERMT3, MASTL, PRKACG, ABCG5 |
| Complement system | C1QBP, CPB2 |
GFI1, growth factor independence 1; IL-17, interleukin-17; JAK/STAT, Janus kinase signal transducer and activator of transcription; TGF-β, transforming growth factor β; Treg, regulatory T cells.