Demographic and clinical characteristics for ACS hospitalizations by ICU transfer status
| Demographics . | No ICU transfer, n = 175 . | ICU transfer, n = 52 . | P value∗ . |
|---|---|---|---|
| Female sex | 93 (53%) | 30 (58%) | .50 |
| Mean age (SD), y | 28.7 (9.7) | 29.7 (10.0) | .59 |
| Non-Hispanic Black | 175 (100%) | 52 (100%) | - |
| Medical history | |||
| BMI (kg/m2) | |||
| Underweight (<18.5) | 24 (14%) | 12 (23%) | .10† |
| Normal (18.5-24.9) | 121 (69%) | 23 (44%) | - |
| Overweight (25-29.9) | 18 (10%) | 9 (17%) | .01† |
| Obese (≥30) | 12 (7%) | 8 (15%) | |
| Smoking history | .32‡ | ||
| Never | 119 (69%) | 27 (53%) | |
| Former | 26 (15%) | 14 (27%) | |
| Current | 28 (16%) | 10 (20%) | |
| SCD type | .34§ | ||
| Hb SS | 123 (70%) | 36 (69%) | |
| Hb SC | 13 (7%) | 4 (8%) | |
| Hb Sβ+ | 5 (3%) | 5 (10%) | |
| Hb Sβ0 | 34 (19%) | 7 (13%) | |
| Prior vaso-occlusive event | 156 (89%) | 46 (90%) | .88 |
| Prior ACS | 146 (83%) | 47 (90%) | .36 |
| Asthma | 68 (39%) | 24 (47%) | .33 |
| COPD | 1 (1%) | 2 (4%) | .15 |
| Splenic sequestration | 27 (16%) | 5 (10%) | .60 |
| Surgical splenectomy | 25 (14%) | 5 (10%) | .69 |
| Stroke | 22 (13%) | 7 (14%) | .58 |
| Current medications | |||
| Home oxygen | 26 (15%) | 17 (33%) | .05 |
| Steroids | 1 (1%) | 2 (4%) | .20 |
| Hydroxyurea | 95 (54%) | 27 (52%) | .59 |
| l-Glutamine | 10 (6%) | 3 (6%) | .98 |
| Voxelotor | 3 (2%) | 0 (0%) | - |
| Crizanlizumab | 1 (1%) | 1 (2%) | .38 |
| Laboratory values at diagnosis, mean (SD) | |||
| White blood cell, ×103/μL | 15.9 (6.2) | 18.1 (7.6) | .09 |
| Hemoglobin, g/dL | 7.7 (1.5) | 7.2 (1.5) | .12 |
| Platelets, ×103/μL | 369 (164) | 284 (136) | .002 |
| Nasal viral positive (%) | 14 (11%) | 5 (11%) | .82 |
| Clinical outcomes | |||
| ACS-directed antibiotics | 172 (98%) | 52 (100%) | - |
| Simple transfusion only | 121 (69%) | 16 (31%) | <.001 |
| Red cell exchange | 10 (6%) | 35 (67%) | <.001 |
| LOS (SD), d | 8.5 (7.4) | 12.0 (9.8) | .025 |
| 28-day readmission | 41 (23%) | 11 (23%) | .88 |
| Demographics . | No ICU transfer, n = 175 . | ICU transfer, n = 52 . | P value∗ . |
|---|---|---|---|
| Female sex | 93 (53%) | 30 (58%) | .50 |
| Mean age (SD), y | 28.7 (9.7) | 29.7 (10.0) | .59 |
| Non-Hispanic Black | 175 (100%) | 52 (100%) | - |
| Medical history | |||
| BMI (kg/m2) | |||
| Underweight (<18.5) | 24 (14%) | 12 (23%) | .10† |
| Normal (18.5-24.9) | 121 (69%) | 23 (44%) | - |
| Overweight (25-29.9) | 18 (10%) | 9 (17%) | .01† |
| Obese (≥30) | 12 (7%) | 8 (15%) | |
| Smoking history | .32‡ | ||
| Never | 119 (69%) | 27 (53%) | |
| Former | 26 (15%) | 14 (27%) | |
| Current | 28 (16%) | 10 (20%) | |
| SCD type | .34§ | ||
| Hb SS | 123 (70%) | 36 (69%) | |
| Hb SC | 13 (7%) | 4 (8%) | |
| Hb Sβ+ | 5 (3%) | 5 (10%) | |
| Hb Sβ0 | 34 (19%) | 7 (13%) | |
| Prior vaso-occlusive event | 156 (89%) | 46 (90%) | .88 |
| Prior ACS | 146 (83%) | 47 (90%) | .36 |
| Asthma | 68 (39%) | 24 (47%) | .33 |
| COPD | 1 (1%) | 2 (4%) | .15 |
| Splenic sequestration | 27 (16%) | 5 (10%) | .60 |
| Surgical splenectomy | 25 (14%) | 5 (10%) | .69 |
| Stroke | 22 (13%) | 7 (14%) | .58 |
| Current medications | |||
| Home oxygen | 26 (15%) | 17 (33%) | .05 |
| Steroids | 1 (1%) | 2 (4%) | .20 |
| Hydroxyurea | 95 (54%) | 27 (52%) | .59 |
| l-Glutamine | 10 (6%) | 3 (6%) | .98 |
| Voxelotor | 3 (2%) | 0 (0%) | - |
| Crizanlizumab | 1 (1%) | 1 (2%) | .38 |
| Laboratory values at diagnosis, mean (SD) | |||
| White blood cell, ×103/μL | 15.9 (6.2) | 18.1 (7.6) | .09 |
| Hemoglobin, g/dL | 7.7 (1.5) | 7.2 (1.5) | .12 |
| Platelets, ×103/μL | 369 (164) | 284 (136) | .002 |
| Nasal viral positive (%) | 14 (11%) | 5 (11%) | .82 |
| Clinical outcomes | |||
| ACS-directed antibiotics | 172 (98%) | 52 (100%) | - |
| Simple transfusion only | 121 (69%) | 16 (31%) | <.001 |
| Red cell exchange | 10 (6%) | 35 (67%) | <.001 |
| LOS (SD), d | 8.5 (7.4) | 12.0 (9.8) | .025 |
| 28-day readmission | 41 (23%) | 11 (23%) | .88 |
COPD, chronic obstructive pulmonary disorder; HB, hemoglobin; SD, standard deviation.
Boldface values indicate P < .05.
Multilevel logistic regression model coefficient P value.
BMI was compared as underweight vs normal as well as overweight/obese vs normal in multilevel logistic regression models.
Smoking dichotomized into never vs prior/current in multilevel logistic regression model.
SCD type dichotomized into SS vs non-SS in multilevel logistic regression model.