OS hazard ratios in univariate Cox proportional hazards model
| Variable . | Hazard ratio . | 95% CI . | P value . |
|---|---|---|---|
| Sex (male) | 1.39 | 0.911-2.13 | .13 |
| Age (<60 years) | 0.40 | 0.25-0.66 | <.001 |
| ECOG PS (3-4) | 3.80 | 2.34-6.17 | <.001 |
| Race (White) | 0.55 | 0.28-1.06 | .07 |
| MSKCC (low risk) | 0.56 | 0.40-0.78 | <.001 |
| Focality (multifocal) | 1.04 | 0.68-1.62 | .83 |
| COO (GCB) | 1.20 | 0.64-2.24 | .58 |
| BCL6 rearrangement | 1.50 | 0.34-6.96 | .63 |
| MYC rearrangement | 3.27 | 0.77-13.71 | .08 |
| DEL status | 1.07 | 0.60-1.91 | .82 |
| MTX resistance | 2.93 | 1.88-4.57 | <.001 |
| EBER ISH (positive) | 0.89 | 0.32-2.47 | .82 |
| Seizure at presentation | 1.05 | 0.53-2.11 | .89 |
| Steroid responsive | 0.38 | 0.23-0.64 | <.001 |
| Elevated LDH | 1.05 | 0.68-1.64 | .82 |
| CR/PR after 2 cycles | 0.27 | 0.17-0.43 | <.001 |
| Deep-brain involvement | 1.07 | 0.69-1.66 | .75 |
| MCD genetic cluster | 1.27 | 0.38-4.19 | .70 |
| Variable . | Hazard ratio . | 95% CI . | P value . |
|---|---|---|---|
| Sex (male) | 1.39 | 0.911-2.13 | .13 |
| Age (<60 years) | 0.40 | 0.25-0.66 | <.001 |
| ECOG PS (3-4) | 3.80 | 2.34-6.17 | <.001 |
| Race (White) | 0.55 | 0.28-1.06 | .07 |
| MSKCC (low risk) | 0.56 | 0.40-0.78 | <.001 |
| Focality (multifocal) | 1.04 | 0.68-1.62 | .83 |
| COO (GCB) | 1.20 | 0.64-2.24 | .58 |
| BCL6 rearrangement | 1.50 | 0.34-6.96 | .63 |
| MYC rearrangement | 3.27 | 0.77-13.71 | .08 |
| DEL status | 1.07 | 0.60-1.91 | .82 |
| MTX resistance | 2.93 | 1.88-4.57 | <.001 |
| EBER ISH (positive) | 0.89 | 0.32-2.47 | .82 |
| Seizure at presentation | 1.05 | 0.53-2.11 | .89 |
| Steroid responsive | 0.38 | 0.23-0.64 | <.001 |
| Elevated LDH | 1.05 | 0.68-1.64 | .82 |
| CR/PR after 2 cycles | 0.27 | 0.17-0.43 | <.001 |
| Deep-brain involvement | 1.07 | 0.69-1.66 | .75 |
| MCD genetic cluster | 1.27 | 0.38-4.19 | .70 |
BCL6, B-cell lymphoma 6; LDH, lactate dehydrogenase; PR, partial response.