Health variables analyzed to develop CHARM, primary analysis population
| Characteristic . | N (%) . |
|---|---|
| No. of patients | 1105 |
| Transplant centers–reported domains | |
| Age at HCT (y) | |
| Evaluable | 1105 |
| Mean (SD) | 67.7 (4.54) |
| Median (25th-75th percentile) | 67.5 (64.1-71.2) |
| Min-max | 60.0-82.2 |
| 60-64 | 350 (31.7%) |
| 65-69 | 399 (36.1%) |
| 70-74 | 295 (26.7%) |
| >75 | 61 (5.5%) |
| Walk speed, 4 m (m/s) | |
| N | 1062 |
| Mean (SD) | 1.0 (0.31) |
| Median (25th-75th percentile) | 1.0 (0.8-1.1) |
| Min-max | 0.1-2.7 |
| <0.8 m/s | 244 (23.0%) |
| ≥0.8 m/s | 818 (77.0%) |
| Weight loss percentage in previous year, n (%) | |
| N | 1008 |
| Median (25th-75th percentile) | 3.2% (0%-8.1%) |
| Min-max | 0%-37.3% |
| No weight loss | 354 (32) |
| <10% | 457 (41) |
| ≥10% (unintentional) | 169 (15) |
| ≥10% (intentional) | 26 (2) |
| ≥10% (intention unknown) | 2 (0) |
| Not reported | 97 (9) |
| Cognition by MoCA | |
| N | 1058 |
| Mean (SD) | 26 (2.92) |
| Median (25th-75th percentile) | 26 (24-28) |
| Min-max | 12-30 |
| <26 | 409 (38.7%) |
| ≥26 | 649 (61.3%) |
| CRP (mg/L) | |
| N | 948 |
| Mean (SD) | 6.1 (12.03) |
| Median (25th-75th percentile) | 2.0 (0.9-6.0) |
| Min-max | 0.04-169 |
| ≤10 | 808 (85.2%) |
| >10 | 140 (14.8%) |
| Serum albumin, g/dL | |
| N | 1101 |
| Mean (SD) | 4.0 (0.42) |
| Median (25th-75th prcentile) | 4.0 (3.7-4.2) |
| Min-max | 2.4-5.3 |
| <3.5 | 122 (11.1%) |
| ≥3.5 | 979 (88.9%) |
| Comorbidity by HCT-CI, n (%) | |
| 0 | 195 (18) |
| 1 | 179 (16) |
| 2 | 168 (15) |
| 3 | 175 (16) |
| 4 | 149 (13) |
| 5 | 91 (8) |
| 6 | 75 (7) |
| 7 | 38 (3) |
| 8 | 20 (2) |
| 9 | 7 (1) |
| 10 | 6 (1) |
| 11 | 2 (0) |
| Patient-reported domains | |
| Karnofsky performance score, n (%) | |
| 40-Disabled, requires special care and assistance | 5 (0) |
| 50-Requires considerable assistance and frequent medical care | 8 (1) |
| 60-Requires occasional assistance but is able to care for most of his/her needs | 65 (6) |
| 70-Cares for self, unable to carry on normal activity or to do active work | 112 (10) |
| 80-Normal activity with effort; some signs or symptoms of disease | 126 (11) |
| 90-Able to carry on normal activity; minor signs or symptoms of disease | 343 (31) |
| 100-Normal, no complaints, no evidence of disease | 313 (28) |
| Not reported | 133 (12) |
| PROMIS Physical Function | |
| N | 976 |
| Mean (SD) | 44.7 (8.38) |
| Median (25th-75th percentile) | 44.0 (39.0-50.0) |
| Min-max | 21.0-67.0 |
| <40 | 264 (27.0%) |
| ≥40 | 712 (73.0%) |
| Instrumental activities of daily living score | |
| N | 982 |
| Mean (SD) | 13.1 (1.63) |
| Median (25th-75th percentile) | 14.0 (13.0-14.0) |
| Min-max | 4.0-14.0 |
| <14 | 359 (36.6%) |
| ≥14 | 623 (63.4%) |
| No. of falls in last 6 mo, no. (%) | |
| 0 | 820 (74) |
| 1 | 122 (11) |
| ≥2 | 35 (3) |
| Not reported | 128 (12) |
| PROMIS Depression | |
| N | 975 |
| Mean (SD) | 45 (7.17) |
| Median (25th-75th percentile) | 44 (38-50) |
| Min-max | 34-66 |
| <60 | 949 (97.3%) |
| ≥60 | 26 (2.7%) |
| Number of prescribed medications | |
| N | 867 |
| Mean (SD) | 6 (3.54) |
| Median (25th-75th percentile) | 5 (3-7) |
| Min-max | 0-27 |
| ≤4 | 386 (44.5%) |
| >4 | 481 (55.5%) |
| Physician-reported survey | |
| Physician prognostic evaluation: alive at 1 y, n (%) | |
| Very good (>90%) | 34 (3) |
| Good (75%-90%) | 268 (24) |
| Better than 50/50 (50%-74%) | 433 (39) |
| Worse than 50/50 (25%-49%) | 178 (16) |
| Bad (10%-24%) | 17 (2) |
| Very bad (<10%) | 1 (0) |
| Not reported | 174 (16) |
| Characteristic . | N (%) . |
|---|---|
| No. of patients | 1105 |
| Transplant centers–reported domains | |
| Age at HCT (y) | |
| Evaluable | 1105 |
| Mean (SD) | 67.7 (4.54) |
| Median (25th-75th percentile) | 67.5 (64.1-71.2) |
| Min-max | 60.0-82.2 |
| 60-64 | 350 (31.7%) |
| 65-69 | 399 (36.1%) |
| 70-74 | 295 (26.7%) |
| >75 | 61 (5.5%) |
| Walk speed, 4 m (m/s) | |
| N | 1062 |
| Mean (SD) | 1.0 (0.31) |
| Median (25th-75th percentile) | 1.0 (0.8-1.1) |
| Min-max | 0.1-2.7 |
| <0.8 m/s | 244 (23.0%) |
| ≥0.8 m/s | 818 (77.0%) |
| Weight loss percentage in previous year, n (%) | |
| N | 1008 |
| Median (25th-75th percentile) | 3.2% (0%-8.1%) |
| Min-max | 0%-37.3% |
| No weight loss | 354 (32) |
| <10% | 457 (41) |
| ≥10% (unintentional) | 169 (15) |
| ≥10% (intentional) | 26 (2) |
| ≥10% (intention unknown) | 2 (0) |
| Not reported | 97 (9) |
| Cognition by MoCA | |
| N | 1058 |
| Mean (SD) | 26 (2.92) |
| Median (25th-75th percentile) | 26 (24-28) |
| Min-max | 12-30 |
| <26 | 409 (38.7%) |
| ≥26 | 649 (61.3%) |
| CRP (mg/L) | |
| N | 948 |
| Mean (SD) | 6.1 (12.03) |
| Median (25th-75th percentile) | 2.0 (0.9-6.0) |
| Min-max | 0.04-169 |
| ≤10 | 808 (85.2%) |
| >10 | 140 (14.8%) |
| Serum albumin, g/dL | |
| N | 1101 |
| Mean (SD) | 4.0 (0.42) |
| Median (25th-75th prcentile) | 4.0 (3.7-4.2) |
| Min-max | 2.4-5.3 |
| <3.5 | 122 (11.1%) |
| ≥3.5 | 979 (88.9%) |
| Comorbidity by HCT-CI, n (%) | |
| 0 | 195 (18) |
| 1 | 179 (16) |
| 2 | 168 (15) |
| 3 | 175 (16) |
| 4 | 149 (13) |
| 5 | 91 (8) |
| 6 | 75 (7) |
| 7 | 38 (3) |
| 8 | 20 (2) |
| 9 | 7 (1) |
| 10 | 6 (1) |
| 11 | 2 (0) |
| Patient-reported domains | |
| Karnofsky performance score, n (%) | |
| 40-Disabled, requires special care and assistance | 5 (0) |
| 50-Requires considerable assistance and frequent medical care | 8 (1) |
| 60-Requires occasional assistance but is able to care for most of his/her needs | 65 (6) |
| 70-Cares for self, unable to carry on normal activity or to do active work | 112 (10) |
| 80-Normal activity with effort; some signs or symptoms of disease | 126 (11) |
| 90-Able to carry on normal activity; minor signs or symptoms of disease | 343 (31) |
| 100-Normal, no complaints, no evidence of disease | 313 (28) |
| Not reported | 133 (12) |
| PROMIS Physical Function | |
| N | 976 |
| Mean (SD) | 44.7 (8.38) |
| Median (25th-75th percentile) | 44.0 (39.0-50.0) |
| Min-max | 21.0-67.0 |
| <40 | 264 (27.0%) |
| ≥40 | 712 (73.0%) |
| Instrumental activities of daily living score | |
| N | 982 |
| Mean (SD) | 13.1 (1.63) |
| Median (25th-75th percentile) | 14.0 (13.0-14.0) |
| Min-max | 4.0-14.0 |
| <14 | 359 (36.6%) |
| ≥14 | 623 (63.4%) |
| No. of falls in last 6 mo, no. (%) | |
| 0 | 820 (74) |
| 1 | 122 (11) |
| ≥2 | 35 (3) |
| Not reported | 128 (12) |
| PROMIS Depression | |
| N | 975 |
| Mean (SD) | 45 (7.17) |
| Median (25th-75th percentile) | 44 (38-50) |
| Min-max | 34-66 |
| <60 | 949 (97.3%) |
| ≥60 | 26 (2.7%) |
| Number of prescribed medications | |
| N | 867 |
| Mean (SD) | 6 (3.54) |
| Median (25th-75th percentile) | 5 (3-7) |
| Min-max | 0-27 |
| ≤4 | 386 (44.5%) |
| >4 | 481 (55.5%) |
| Physician-reported survey | |
| Physician prognostic evaluation: alive at 1 y, n (%) | |
| Very good (>90%) | 34 (3) |
| Good (75%-90%) | 268 (24) |
| Better than 50/50 (50%-74%) | 433 (39) |
| Worse than 50/50 (25%-49%) | 178 (16) |
| Bad (10%-24%) | 17 (2) |
| Very bad (<10%) | 1 (0) |
| Not reported | 174 (16) |
Max, maximum; Min, minimum; SD, standard deviation.