Demographic, clinical, and laboratory data for the SCA sample at month 0 vs month 18
| . | SCA at month 0 (N = 264) . | SCA at month 18 (N = 254) . | Differences (month 18-month 0) (N = 254) . | P value . |
|---|---|---|---|---|
| Age (y) | 5.6 ± 1.2 | 7.1 ± 1.7 | ||
| Sex (female) | 137 (51.9%) | 131 (52.0%) | NS | |
| Malnutrition∗ (%) | 24 (9.2) | n = 241 19 (7.9) | NS | |
| Oxygen saturation (in %) | n = 263 95.9 ± 6.8 | 97.4 ± 2.0 | n = 253 1.4 ± 7.1 | .002 |
| HU dose (mg/kg) | n = 263 20.2 ± 0.9 | n = 253 25.4 ± 3.1 | n = 252 5.2 ± 3.1 | <.001 |
| Hb (g/dL) | 7.8 ± 1.2 | 8.8 ± 1.3 | 1.0 ± 1.2 | <.001 |
| Fetal Hb (in %) | n = 256 11.9 ± 8.1 | 23.7 ± 11.2 | n = 242 12.0 ± 10.7 | <.001 |
| MCV (fL) | 81.0 ± 8.9 | 96.9 ± 10.8 | 15.9 ± 8.8 | <.001 |
| WBC (×109/L) | 13.8 ± 4.2 | 9.6 ± 3.2 | −4.1 ± 4.2 | <.001 |
| ANC (×109/L) | 5.6 ± 2.3 | 3.9 ± 1.8 | −1.7 ± 2.5 | <.001 |
| ARC (×109/L) | n = 262 344.7 ± 120.0 | 212.2 ± 101.6 | −130.1 ± 122.8 | <.001 |
| Platelets (×109/L) | n = 263 443.7 ± 153.0 | 368.2 ± 168.4 | n= 253 −76.1 ± 191.9 | <.001 |
| TCD TAMV† (cm/s) | n = 257 148.4 ± 29.2 | n = 246 130.9 ± 21.3 | n = 242 −17.5 ± 22.2 | <.001 |
| TCD category‡ , n (%) | ||||
| Abnormal | 15 (5.7) | 4 (1.6) | Kappa = 0.24 (95% confidence interval, 0.12-0.36) | <.001 |
| Conditional | 42 (15.9) | 10 (3.9) | ||
| Normal | 191 (72.4) | 228 (89.8) | ||
| Inadequate | 16 (6.1) | 12 (4.7) |
| . | SCA at month 0 (N = 264) . | SCA at month 18 (N = 254) . | Differences (month 18-month 0) (N = 254) . | P value . |
|---|---|---|---|---|
| Age (y) | 5.6 ± 1.2 | 7.1 ± 1.7 | ||
| Sex (female) | 137 (51.9%) | 131 (52.0%) | NS | |
| Malnutrition∗ (%) | 24 (9.2) | n = 241 19 (7.9) | NS | |
| Oxygen saturation (in %) | n = 263 95.9 ± 6.8 | 97.4 ± 2.0 | n = 253 1.4 ± 7.1 | .002 |
| HU dose (mg/kg) | n = 263 20.2 ± 0.9 | n = 253 25.4 ± 3.1 | n = 252 5.2 ± 3.1 | <.001 |
| Hb (g/dL) | 7.8 ± 1.2 | 8.8 ± 1.3 | 1.0 ± 1.2 | <.001 |
| Fetal Hb (in %) | n = 256 11.9 ± 8.1 | 23.7 ± 11.2 | n = 242 12.0 ± 10.7 | <.001 |
| MCV (fL) | 81.0 ± 8.9 | 96.9 ± 10.8 | 15.9 ± 8.8 | <.001 |
| WBC (×109/L) | 13.8 ± 4.2 | 9.6 ± 3.2 | −4.1 ± 4.2 | <.001 |
| ANC (×109/L) | 5.6 ± 2.3 | 3.9 ± 1.8 | −1.7 ± 2.5 | <.001 |
| ARC (×109/L) | n = 262 344.7 ± 120.0 | 212.2 ± 101.6 | −130.1 ± 122.8 | <.001 |
| Platelets (×109/L) | n = 263 443.7 ± 153.0 | 368.2 ± 168.4 | n= 253 −76.1 ± 191.9 | <.001 |
| TCD TAMV† (cm/s) | n = 257 148.4 ± 29.2 | n = 246 130.9 ± 21.3 | n = 242 −17.5 ± 22.2 | <.001 |
| TCD category‡ , n (%) | ||||
| Abnormal | 15 (5.7) | 4 (1.6) | Kappa = 0.24 (95% confidence interval, 0.12-0.36) | <.001 |
| Conditional | 42 (15.9) | 10 (3.9) | ||
| Normal | 191 (72.4) | 228 (89.8) | ||
| Inadequate | 16 (6.1) | 12 (4.7) |
Bold values indicate significance at P < .05.
ANC, absolute neutrophil count; ARC, absolute reticulocyte count; MCV, mean corpuscular volume; NS, not significant.
Defined as weight-for-age z score below −2.0 by WHO global standards.13
TCD mean time-averaged maximum velocity, excluding inadequate scans.
Per international standards for children with SCA.5