Neurocognitive mean z scores comparing the composite scores for the SCA sample at months 0 and 18
| Composite test (age in y) . | SCA at month 0 . | SCA at month 18 . | Difference∗ . | P value . |
|---|---|---|---|---|
| KABC-II MPI (≥4 y) | n = 208† | n = 202† | n = 201 | |
| Cognition | −0.54 ± 1.10 | −0.07 ± 1.16 | 0.45 ± 0.84 | <.001 |
| TOVA D’ (≥5 y) | n = 152 | n = 150 | n = 146 | |
| Attention | −0.07 ± 1.01 | 0.27 ± 0.84 | 0.35 ± 0.97 | <.001 |
| BRIEF GEC (all ages)‡ | n = 264 | n = 254 | n = 254 | |
| Executive function | −0.06 ± 0.62 | 0.08 ± 0.72 | −0.15 ± 0.92 | .010 |
| NEPSY-II AAR (≥7 y) | n = 60 | n = 62 | n = 59 | |
| Executive function | −0.38 ± 0.93 | −0.09 ± 0.97 | 0.32 ± 1.18 | .035 |
| Composite test (age in y) . | SCA at month 0 . | SCA at month 18 . | Difference∗ . | P value . |
|---|---|---|---|---|
| KABC-II MPI (≥4 y) | n = 208† | n = 202† | n = 201 | |
| Cognition | −0.54 ± 1.10 | −0.07 ± 1.16 | 0.45 ± 0.84 | <.001 |
| TOVA D’ (≥5 y) | n = 152 | n = 150 | n = 146 | |
| Attention | −0.07 ± 1.01 | 0.27 ± 0.84 | 0.35 ± 0.97 | <.001 |
| BRIEF GEC (all ages)‡ | n = 264 | n = 254 | n = 254 | |
| Executive function | −0.06 ± 0.62 | 0.08 ± 0.72 | −0.15 ± 0.92 | .010 |
| NEPSY-II AAR (≥7 y) | n = 60 | n = 62 | n = 59 | |
| Executive function | −0.38 ± 0.93 | −0.09 ± 0.97 | 0.32 ± 1.18 | .035 |
Bold values indicate significance at P < .5.
For each measure, the same participants were compared between the 2 time points.
BRIEF GEC, Behavior Rating Inventory of Executive Function Global Executive Composite; KABC-II MPI, Kaufman Assessment Battery for Children, second edition, Mental Processing Index; NEPSY-II AAR, Developmental Neuropsychological Assessment; TOVA, Test of Variables of Attention.
The same participant sample was compared in the analysis of each measure.
17 (8.2%) were cognitively impaired (z score below −2.0) at enrollment compared with 8 (4.0%) at month 18.
BRIEF scores were flipped (multiplying by −1.0) for consistency in direction of change across measures used.14