Bivariate and multivariate analyses of improved neurocognitive z scores at month 18 from enrollment among the SCA sample for each of the 4 measures
| Cognition (n = 201), ages ≥4 y at enrolment . | ||||
|---|---|---|---|---|
| Predictors at mo 18 . | Bivariate analysis (adjusted for score at enrollment) . | Multivariable analysis . | ||
| Coefficient (SE) . | P value . | Coefficient (SE) . | P value . | |
| Score at enrollment | −0.28 (0.053) | <.001 | ||
| SES∗ | 0.054 (0.024) | .03 | 0.05 (0.025) | .048 |
| Platelets (×109/L) | −0.001 (0.0004) | .03 | −0.0007 (0.0004) | .047 |
| Attention (n = 146), ages ≥5 y at enrolment | ||||
| Predictors at month 18 | Bivariate analysis (adjusted for score at enrollment) | Multivariable analysis | ||
| Coefficient (SE) | P value | Coefficient (SE) | P value | |
| Score at enrollment | −0.69 (0.065) | <.001 | ||
| WBC (×106/L) | −0.038 (0.015) | .015 | −0.003 (0.024) | .91 |
| ARC (×106/L) | −0.001 (0.0005) | .014 | −0.001 (0.0006) | .15 |
| Executive function (n = 254), all ages at enrolment | ||||
| Predictors at month 18 | Bivariate analysis (adjusted for score at enrollment) | Multivariable analysis | ||
| Coefficient (SE) | P value | Coefficient (SE) | P value | |
| Score at enrollment | −0.93 (0.071) | <.001 | ||
| SES∗ | 0.048 (0.020) | .015 | 0.05 (0.020) | .015 |
| Executive function (n = 59), ages ≥7 y at enrolment | ||||
| Predictors at month 18 | Bivariate analysis (adjusted for score at enrollment) | Multivariable analysis | ||
| Coefficient (SE) | P value | Coefficient (SE) | P value | |
| Score at enrollment | −0.60 (0.146) | <.001 | ||
| Hb (g/dL) | 0.26 (0.114) | .025 | 0.32 (0.121) | .012 |
| TCD TAMV (cm/s)† | 0.006 (0.004) | .144 | 0.009 (0.004) | .032 |
| Cognition (n = 201), ages ≥4 y at enrolment . | ||||
|---|---|---|---|---|
| Predictors at mo 18 . | Bivariate analysis (adjusted for score at enrollment) . | Multivariable analysis . | ||
| Coefficient (SE) . | P value . | Coefficient (SE) . | P value . | |
| Score at enrollment | −0.28 (0.053) | <.001 | ||
| SES∗ | 0.054 (0.024) | .03 | 0.05 (0.025) | .048 |
| Platelets (×109/L) | −0.001 (0.0004) | .03 | −0.0007 (0.0004) | .047 |
| Attention (n = 146), ages ≥5 y at enrolment | ||||
| Predictors at month 18 | Bivariate analysis (adjusted for score at enrollment) | Multivariable analysis | ||
| Coefficient (SE) | P value | Coefficient (SE) | P value | |
| Score at enrollment | −0.69 (0.065) | <.001 | ||
| WBC (×106/L) | −0.038 (0.015) | .015 | −0.003 (0.024) | .91 |
| ARC (×106/L) | −0.001 (0.0005) | .014 | −0.001 (0.0006) | .15 |
| Executive function (n = 254), all ages at enrolment | ||||
| Predictors at month 18 | Bivariate analysis (adjusted for score at enrollment) | Multivariable analysis | ||
| Coefficient (SE) | P value | Coefficient (SE) | P value | |
| Score at enrollment | −0.93 (0.071) | <.001 | ||
| SES∗ | 0.048 (0.020) | .015 | 0.05 (0.020) | .015 |
| Executive function (n = 59), ages ≥7 y at enrolment | ||||
| Predictors at month 18 | Bivariate analysis (adjusted for score at enrollment) | Multivariable analysis | ||
| Coefficient (SE) | P value | Coefficient (SE) | P value | |
| Score at enrollment | −0.60 (0.146) | <.001 | ||
| Hb (g/dL) | 0.26 (0.114) | .025 | 0.32 (0.121) | .012 |
| TCD TAMV (cm/s)† | 0.006 (0.004) | .144 | 0.009 (0.004) | .032 |
Bold values indicate significance at P < .5.
Bivariate analysis tested for predictors listed in Table 2, adjusted for the z score at enrollment. Variables that were significant in the bivariate analysis (P < .2) were selected for multivariable analysis. Only predictors with significant effects are listed.
Complete data are available on request.
ARC, absolute reticulocyte count.
Socioeconomic scale, per locally validated scale.24
TCD velocity mean time-averaged maximum velocity.