Management issues and AEs that occurred in the BTKi cohort
| Management issues and AEs . | n (%) . |
|---|---|
| Hematologic toxicity grade 3-4 | 18 (15) |
| Anemia grade 3-4 | 6 (5) |
| Neutropenia grade 3-4 | 12 (10) |
| Infections grade 1-2 | 35 (29) |
| Infections grade 3-4 | 24 (20) |
| Cardiovascular events, any grade | 31 (26) |
| Cardiovascular events, grade 3-4 | 6 (5) |
| Bleeding grade 1-2 | 37 (31) |
| Bleeding grade 3-4 | 4 (3) |
| Second neoplasia | 12 (10) |
| Definite interruption | 51 (43) |
| Caused by toxicity | 17 (14) |
| Caused by PD | 18 (15) |
| Caused by an infectious event | 6 (5) |
| Caused by death | 7 (6) |
| Caused by second neoplasia | 7 (6) |
| Deaths | 29 (24) |
| Management issues and AEs . | n (%) . |
|---|---|
| Hematologic toxicity grade 3-4 | 18 (15) |
| Anemia grade 3-4 | 6 (5) |
| Neutropenia grade 3-4 | 12 (10) |
| Infections grade 1-2 | 35 (29) |
| Infections grade 3-4 | 24 (20) |
| Cardiovascular events, any grade | 31 (26) |
| Cardiovascular events, grade 3-4 | 6 (5) |
| Bleeding grade 1-2 | 37 (31) |
| Bleeding grade 3-4 | 4 (3) |
| Second neoplasia | 12 (10) |
| Definite interruption | 51 (43) |
| Caused by toxicity | 17 (14) |
| Caused by PD | 18 (15) |
| Caused by an infectious event | 6 (5) |
| Caused by death | 7 (6) |
| Caused by second neoplasia | 7 (6) |
| Deaths | 29 (24) |
PD, progressive disease.