Pathological disorders associated with FcγRIIA activation
| Disorder . | PF4 participation . | Heparin participation . | Vaccine participation . | Antecedent viral infection/surgery . |
|---|---|---|---|---|
| Heparin-induced thrombocytopenia | + | + | – | – |
| Vaccine-induced thrombotic thrombocytopenia | + | – | + | – |
| Autoimmune heparin-induced thrombocytopenia | + | + | – | – |
| Autoimmune anti-PF4 syndrome | + | – | – | + |
| Paraprotein-associated chronic thrombocytopenia/thrombosis | + | – | – | – |
| GPI-induced thrombocytopenia with platelet activation/thrombosis | – | – | – | – |
| Therapeutic mAb-induced thrombocytopenia/thrombosis | – | – | – | – |
| mAb-drug conjugate–induced thrombocytopenia and liver/macrophage injury | – | – | – | – |
| Thrombotic cardiovascular disease | – | – | – |
| Disorder . | PF4 participation . | Heparin participation . | Vaccine participation . | Antecedent viral infection/surgery . |
|---|---|---|---|---|
| Heparin-induced thrombocytopenia | + | + | – | – |
| Vaccine-induced thrombotic thrombocytopenia | + | – | + | – |
| Autoimmune heparin-induced thrombocytopenia | + | + | – | – |
| Autoimmune anti-PF4 syndrome | + | – | – | + |
| Paraprotein-associated chronic thrombocytopenia/thrombosis | + | – | – | – |
| GPI-induced thrombocytopenia with platelet activation/thrombosis | – | – | – | – |
| Therapeutic mAb-induced thrombocytopenia/thrombosis | – | – | – | – |
| mAb-drug conjugate–induced thrombocytopenia and liver/macrophage injury | – | – | – | – |
| Thrombotic cardiovascular disease | – | – | – |