Immunochemistry and histologic findings
| Patients . | N = 50 . |
|---|---|
| Peripheral limitation, n (%) | |
| Well circumscribed | 33 (87) |
| Irregular | 2 (5) |
| Invasive | 3 (8) |
| N/A | 12 |
| Pushing borders, yes/no, n (%) | 33/8 (80/20) |
| N/A | 9 |
| Epidermotropism, n (%) | |
| Absent | 37 (79) |
| Present, occasional | 9 (19) |
| Present, frequent | 1 (2) |
| N/A | 3 |
| Deepness of infiltration, n (%) | |
| Only upper- and mid-dermis | 1 (2) |
| Deep dermis | 27 (68) |
| Hypodermis | 12 (30) |
| N/A | 10 |
| Foamy histiocytes, n (%) | |
| Absent | 16 (32) |
| <50% of histiocytes | 27 (54) |
| >50% of histiocytes | 7 (14) |
| Touton giant cells/non-Touton giant cells, n (%) | |
| Absent | 24/13 (48/26) |
| Few | 16/14 (32/28) |
| Numerous | 10/23 (20/46) |
| Emperipolesis in multinucleated cells/nonmultinucleated cells, n (%) | |
| Absent | 27/35 (54/70) |
| Few | 12/10 (24/20) |
| Moderate | 6/4 (12/8) |
| Numerous | 5/1 (10/2) |
| Nucleus size, n (%) | |
| <2× lymphocyte’s size | 8 (16) |
| 2-3× lymphocyte’s size | 37 (74) |
| >3× lymphocyte’s size | 5 (10) |
| Chromatin, hypochromatism/hyperchromatism, n (%) | 49/1 (98/2) |
| Folded/indented nuclei, n (%) | |
| Absent | 5 (10) |
| Rare | 37 (74) |
| Frequent | 8 (16) |
| Anisocaryosis, n (%) | |
| Absent | 4 (8) |
| Rare | 40 (80) |
| Frequent | 6 (12) |
| Nucleoli, n (%) | |
| Conspicuous at 40× magnification | 42 (84) |
| Conspicuous at 10× magnification | 7 (14) |
| Conspicuous at 2.5× magnification | 1 (2) |
| Cytoplasm eosinophilic/basophilic, n (%) | 50/0 (100/0) |
| Cytoplasmic abundance, n (%) | |
| Scant cytoplasm | 9 (18) |
| Moderate abundance | 35 (70) |
| Abundant cytoplasm | 6 (12) |
| Granular cytoplasm, n (%) | 0 (0) |
| Stroma, n (%) | |
| Neutrophils | 4 (8) |
| Eosinophils | 22 (44) |
| Lymphocytes | 46 (92) |
| Plasma cells | 1 (2) |
| Siderophages, n (%) | 2 (4) |
| Early-like lesions, yes/no, n (%) | 10/39 (20/80) |
| Pan-TRK immunochemistry, n (%) | |
| 4+ | 15 (30) |
| 3+ | 14 (28) |
| 2+ | 12 (24) |
| 1+ | 7 (14) |
| Positive but intensity N/A | 2 (4) |
| Patients . | N = 50 . |
|---|---|
| Peripheral limitation, n (%) | |
| Well circumscribed | 33 (87) |
| Irregular | 2 (5) |
| Invasive | 3 (8) |
| N/A | 12 |
| Pushing borders, yes/no, n (%) | 33/8 (80/20) |
| N/A | 9 |
| Epidermotropism, n (%) | |
| Absent | 37 (79) |
| Present, occasional | 9 (19) |
| Present, frequent | 1 (2) |
| N/A | 3 |
| Deepness of infiltration, n (%) | |
| Only upper- and mid-dermis | 1 (2) |
| Deep dermis | 27 (68) |
| Hypodermis | 12 (30) |
| N/A | 10 |
| Foamy histiocytes, n (%) | |
| Absent | 16 (32) |
| <50% of histiocytes | 27 (54) |
| >50% of histiocytes | 7 (14) |
| Touton giant cells/non-Touton giant cells, n (%) | |
| Absent | 24/13 (48/26) |
| Few | 16/14 (32/28) |
| Numerous | 10/23 (20/46) |
| Emperipolesis in multinucleated cells/nonmultinucleated cells, n (%) | |
| Absent | 27/35 (54/70) |
| Few | 12/10 (24/20) |
| Moderate | 6/4 (12/8) |
| Numerous | 5/1 (10/2) |
| Nucleus size, n (%) | |
| <2× lymphocyte’s size | 8 (16) |
| 2-3× lymphocyte’s size | 37 (74) |
| >3× lymphocyte’s size | 5 (10) |
| Chromatin, hypochromatism/hyperchromatism, n (%) | 49/1 (98/2) |
| Folded/indented nuclei, n (%) | |
| Absent | 5 (10) |
| Rare | 37 (74) |
| Frequent | 8 (16) |
| Anisocaryosis, n (%) | |
| Absent | 4 (8) |
| Rare | 40 (80) |
| Frequent | 6 (12) |
| Nucleoli, n (%) | |
| Conspicuous at 40× magnification | 42 (84) |
| Conspicuous at 10× magnification | 7 (14) |
| Conspicuous at 2.5× magnification | 1 (2) |
| Cytoplasm eosinophilic/basophilic, n (%) | 50/0 (100/0) |
| Cytoplasmic abundance, n (%) | |
| Scant cytoplasm | 9 (18) |
| Moderate abundance | 35 (70) |
| Abundant cytoplasm | 6 (12) |
| Granular cytoplasm, n (%) | 0 (0) |
| Stroma, n (%) | |
| Neutrophils | 4 (8) |
| Eosinophils | 22 (44) |
| Lymphocytes | 46 (92) |
| Plasma cells | 1 (2) |
| Siderophages, n (%) | 2 (4) |
| Early-like lesions, yes/no, n (%) | 10/39 (20/80) |
| Pan-TRK immunochemistry, n (%) | |
| 4+ | 15 (30) |
| 3+ | 14 (28) |
| 2+ | 12 (24) |
| 1+ | 7 (14) |
| Positive but intensity N/A | 2 (4) |