Table 2.

Features of the recombinant IgG4 anti-FVIII drug antibodies employed in the study

AntibodyBinding domainEpitope (UniProt P00451 numbering)References
BO2C11 C2 F2215, N2217, M2218, F2219, R2234, and R2239 34,37  
LE2E9 C1 E2085, R2169 21,34  
KM33 C1 Residues 2110-2123 and 2176-2181 35,36  
KM41 A3 R1822-K1837 20,33  
BOIIB2 A2 Residues 398-475 32  
AntibodyBinding domainEpitope (UniProt P00451 numbering)References
BO2C11 C2 F2215, N2217, M2218, F2219, R2234, and R2239 34,37  
LE2E9 C1 E2085, R2169 21,34  
KM33 C1 Residues 2110-2123 and 2176-2181 35,36  
KM41 A3 R1822-K1837 20,33  
BOIIB2 A2 Residues 398-475 32  
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