Table 3. Preintervention GM associations... | American Society of Hematology

Table 3.

Preintervention GM associations with transplant-related toxicities

Characteristic	n	OR/IRR	95% CI	P value	Estimate of RC	Standard error	t value	P value	Adjusted P value
Preintervention Faecalibacterium abundance
Mucositis	79
Occurrence		0.99	0.92-1.06	.7					.90
Severity					−0.002	0.035	−0.062	.9	.90
Nausea	79
Occurrence		1.04	0.94-1.17	.46					.90
Severity					0.051	0.035	1.443	.1	.45
Onset		0.99∗	0.97-1.01	.2					.72
Duration		1.00∗	0.98-1.02	.5					.90
Vomiting
Occurrence	78	1.02	0.95-1.09	.5					.90
Severity	78				0.018	0.035	0.527	.5	.90
Onset	79	0.98∗	0.96-1.00	.1					.45
Duration	79	1.00∗	0.98-1.03	.9					.90
Diarrhea	79
Occurrence		1.0∗	0.90-1.17	.8					.90
Severity					−0.008	0.034	−0.24	.8	.90
Onset		1.01∗	0.99-1.02	.4					.90
Duration		0.99∗	0.98-1.00	.09					.45
Neutropenic fever	79	1.02	0.95-1.10	.62					.90
Occurrence
Major infection
Occurrence	79	0.99	0.90-1.07	.7					.90
Engraftment syndrome	79
Occurrence		1.00	0.92-1.07	.9					.9
Duration of treatment steroids		0.95∗	0.92-0.97	<.001					<.001
α-Diversity
Mucositis	79
Occurrence		1.00	0.99-1.01	.7	0.003	0.005	0.651	.5	.8
Severity									.75
Nausea	79
Occurrence		1.00	0.99-1.02	.5					.75
Severity					0.005	0.005	0.894	.3	.54
Onset		1.00∗	1.00-1.00	.2					.54
Duration		1.00∗	1.0-1.00	.001					.009
Vomiting
Occurrence	78	1.00	1.00-1.02	.3					.54
Severity	78				0.005	0.005	0.892	.3	.54
Onset	79	1.00∗	0.99-1.00	.02					.09
Duration	79	1.00∗	1.00-1.01	.3					.54
Diarrhea	79
Occurrence		1.00	0.98-1.02	.8					.80
Severity					−0.002	0.005	−0.449	.6	.80
Onset		1.00∗	1.00-1.00	.8					.80
Duration		1.00∗	1.00-1.00	.002					.01
Neutropenic fever
Occurrence	79	0.99	0.98-1.01	.3					.54
Major infection
Occurrence	79	1.00	0.99-1.01	.8					.80
Engraftment syndrome	79
Occurrence		1.00	0.99-1.01	.7					.80
Duration of treatment steroids		0.99∗	0.99-1.00	<.001					.009

Characteristic	n	OR/IRR	95% CI	P value	Estimate of RC	Standard error	t value	P value	Adjusted P value
Preintervention Faecalibacterium abundance
Mucositis	79
Occurrence		0.99	0.92-1.06	.7					.90
Severity					−0.002	0.035	−0.062	.9	.90
Nausea	79
Occurrence		1.04	0.94-1.17	.46					.90
Severity					0.051	0.035	1.443	.1	.45
Onset		0.99∗	0.97-1.01	.2					.72
Duration		1.00∗	0.98-1.02	.5					.90
Vomiting
Occurrence	78	1.02	0.95-1.09	.5					.90
Severity	78				0.018	0.035	0.527	.5	.90
Onset	79	0.98∗	0.96-1.00	.1					.45
Duration	79	1.00∗	0.98-1.03	.9					.90
Diarrhea	79
Occurrence		1.0∗	0.90-1.17	.8					.90
Severity					−0.008	0.034	−0.24	.8	.90
Onset		1.01∗	0.99-1.02	.4					.90
Duration		0.99∗	0.98-1.00	.09					.45
Neutropenic fever	79	1.02	0.95-1.10	.62					.90
Occurrence
Major infection
Occurrence	79	0.99	0.90-1.07	.7					.90
Engraftment syndrome	79
Occurrence		1.00	0.92-1.07	.9					.9
Duration of treatment steroids		0.95∗	0.92-0.97	<.001					<.001
α-Diversity
Mucositis	79
Occurrence		1.00	0.99-1.01	.7	0.003	0.005	0.651	.5	.8
Severity									.75
Nausea	79
Occurrence		1.00	0.99-1.02	.5					.75
Severity					0.005	0.005	0.894	.3	.54
Onset		1.00∗	1.00-1.00	.2					.54
Duration		1.00∗	1.0-1.00	.001					.009
Vomiting
Occurrence	78	1.00	1.00-1.02	.3					.54
Severity	78				0.005	0.005	0.892	.3	.54
Onset	79	1.00∗	0.99-1.00	.02					.09
Duration	79	1.00∗	1.00-1.01	.3					.54
Diarrhea	79
Occurrence		1.00	0.98-1.02	.8					.80
Severity					−0.002	0.005	−0.449	.6	.80
Onset		1.00∗	1.00-1.00	.8					.80
Duration		1.00∗	1.00-1.00	.002					.01
Neutropenic fever
Occurrence	79	0.99	0.98-1.01	.3					.54
Major infection
Occurrence	79	1.00	0.99-1.01	.8					.80
Engraftment syndrome	79
Occurrence		1.00	0.99-1.01	.7					.80
Duration of treatment steroids		0.99∗	0.99-1.00	<.001					.009

Bold values , a p-value < 0.05.

IRR, incidence rate ratio; OR, odds ratio; RC, regression coefficient.

Incidence rate ratio values