IgG levels and hypogammaglobulinemia before and after IgRT initiation in patients with MM
| . | Overall . | P value . |
|---|---|---|
| Patients with ≥1 IgG test 3 months before and after IgRT initiation∗ | n = 227 | |
| IgG level immediately before IgRT initiation,† mg/dL | ||
| Mean ± SD | 666.2 ± 748.5 | Reference |
| Median (IQR) | 410.0 (307.0-682.0) | |
| IgG level 3 months after IgRT initiation,‡ mg/dL | ||
| Mean ± SD | 759.4 ± 624.2 | <.0001§ |
| Median (IQR) | 609.0 (434.0-855.0) | |
| Proportion of patients with hypogammaglobulinemia 3 months before IgRT initiation||,¶, n (%) | 135 (59.5) | <.0001§ |
| Proportion of patients with hypogammaglobulinemia 3 months after IgRT initiation||,¶, n (%) | 55 (24.2) | |
| Patients with ≥1 IgG test 6 months before and after IgRT initiation∗ | n = 281 | |
| IgG level immediately before IgRT initiation,† mg/dL | ||
| Mean ± SD | 692.0 ± 806.0 | Reference |
| Median (IQR) | 434.0 (308.0-714.0) | |
| IgG level after IgRT initiation,‡ mg/dL | ||
| Mean ± SD | 728.6 ± 631.4 | <.0001§ |
| Median (IQR) | 566.0 (397.0-822.0) | |
| Proportion of patients with hypogammaglobulinemia 6 months before IgRT initiation||,¶, n (%) | 159 (56.6) | <.0001§ |
| Proportion of patients with hypogammaglobulinemia 6 months after IgRT initiation||,¶, n (%) | 74 (26.3) | |
| Patients with ≥1 IgG test 12 months before and after IgRT initiation∗ | n = 308 | |
| IgG level immediately before IgRT initiation,† mg/dL | ||
| Mean ± SD | 696.9 ± 820.2 | Reference |
| Median (IQR) | 433.0 (307.5-733.0) | |
| IgG level after IgRT initiation,‡ mg/dL | ||
| Mean ± SD | 722.8 ± 612.5 | <.0001§ |
| Median (IQR) | 566.0 (392.0-821.0) | |
| Proportion of patients with hypogammaglobulinemia 12 months before IgRT initiation||,¶, n (%) | 173 (56.2) | <.0001§ |
| Proportion of patients with hypogammaglobulinemia 12 months after IgRT initiation||,¶, n (%) | 82 (26.6) |
| . | Overall . | P value . |
|---|---|---|
| Patients with ≥1 IgG test 3 months before and after IgRT initiation∗ | n = 227 | |
| IgG level immediately before IgRT initiation,† mg/dL | ||
| Mean ± SD | 666.2 ± 748.5 | Reference |
| Median (IQR) | 410.0 (307.0-682.0) | |
| IgG level 3 months after IgRT initiation,‡ mg/dL | ||
| Mean ± SD | 759.4 ± 624.2 | <.0001§ |
| Median (IQR) | 609.0 (434.0-855.0) | |
| Proportion of patients with hypogammaglobulinemia 3 months before IgRT initiation||,¶, n (%) | 135 (59.5) | <.0001§ |
| Proportion of patients with hypogammaglobulinemia 3 months after IgRT initiation||,¶, n (%) | 55 (24.2) | |
| Patients with ≥1 IgG test 6 months before and after IgRT initiation∗ | n = 281 | |
| IgG level immediately before IgRT initiation,† mg/dL | ||
| Mean ± SD | 692.0 ± 806.0 | Reference |
| Median (IQR) | 434.0 (308.0-714.0) | |
| IgG level after IgRT initiation,‡ mg/dL | ||
| Mean ± SD | 728.6 ± 631.4 | <.0001§ |
| Median (IQR) | 566.0 (397.0-822.0) | |
| Proportion of patients with hypogammaglobulinemia 6 months before IgRT initiation||,¶, n (%) | 159 (56.6) | <.0001§ |
| Proportion of patients with hypogammaglobulinemia 6 months after IgRT initiation||,¶, n (%) | 74 (26.3) | |
| Patients with ≥1 IgG test 12 months before and after IgRT initiation∗ | n = 308 | |
| IgG level immediately before IgRT initiation,† mg/dL | ||
| Mean ± SD | 696.9 ± 820.2 | Reference |
| Median (IQR) | 433.0 (307.5-733.0) | |
| IgG level after IgRT initiation,‡ mg/dL | ||
| Mean ± SD | 722.8 ± 612.5 | <.0001§ |
| Median (IQR) | 566.0 (392.0-821.0) | |
| Proportion of patients with hypogammaglobulinemia 12 months before IgRT initiation||,¶, n (%) | 173 (56.2) | <.0001§ |
| Proportion of patients with hypogammaglobulinemia 12 months after IgRT initiation||,¶, n (%) | 82 (26.6) |
Tests performed on the date of IgRT initiation were not included. If multiple tests were performed on the same day, the average value was calculated.
The IgG test result closest to the date of IgRT initiation was used.
P value for comparison of IgG level before vs after IgRT initiation was estimated using the Wilcoxon signed-rank test.
Statistically significant at P value <.05.
Hypogammaglobulinemia was defined as IgG level <500 mg/dL.
P value was calculated using McNemar test.