Table 2. Drug formulation and dosing... | American Society of Hematology

Table 2.

Drug formulation and dosing reference

Drug	Formulation	Route	Loading dose	Maintenance dose
Iptacopan		Oral	n/a	200 mg bid⁹^,¹⁷
Pegcetacoplan		SQ 30-90 min	n/a	SQ 1080 mg⁷ q2 weeks
Danicopan		Add-on oral to IV C5 inhibitor	n/a	150-200 mg²⁵ tid
Crovalimab		IV >1 hour or SC	1000 mg IV on day 1; 340 mg SC on days 2, 8, 15, 22	SC 680 mg day¹⁴^,²⁷ and then q4 weeks
Eculizumab		IV >1 hour	600 mg q1 week for 4 weeks	900 mg q2¹¹ weeks
Ravulizumab		IV >1 hour	2700 mg IV	Loading dose of 3300 mg IV q8 weeks, then q2 weeks⁴

Drug	Formulation	Route	Loading dose	Maintenance dose
Iptacopan		Oral	n/a	200 mg bid⁹^,¹⁷
Pegcetacoplan		SQ 30-90 min	n/a	SQ 1080 mg⁷ q2 weeks
Danicopan		Add-on oral to IV C5 inhibitor	n/a	150-200 mg²⁵ tid
Crovalimab		IV >1 hour or SC	1000 mg IV on day 1; 340 mg SC on days 2, 8, 15, 22	SC 680 mg day¹⁴^,²⁷ and then q4 weeks
Eculizumab		IV >1 hour	600 mg q1 week for 4 weeks	900 mg q2¹¹ weeks
Ravulizumab		IV >1 hour	2700 mg IV	Loading dose of 3300 mg IV q8 weeks, then q2 weeks⁴

bid, twice daily; n/a, not available; q, every; SQ, SC infusion pump; tid, 3 times per day.